Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$80K - $95K *
Reimagine payroll processes by building and managing US and international payroll systems. Own compliance, tax filings, and month-end close while collaborating with teams to ensure accuracy and effici...
4 days ago
$81K - $130K *
Lead the charge in delivering high-impact market research solutions, managing multiple projects, and fostering client relationships. Coach and elevate team standards while utilizing innovative methodo...
4 days ago
$90K - $110K *
Unlock your potential by designing advanced PCB layouts and collaborating on innovative RF designs. This remote role requires expertise in Altium and a strong understanding of PCB standards to drive q...
4 days ago
$160K - $185K *
Lead the charge in designing Azure platforms for healthcare data products, ensuring resilience, security, and cost management while mentoring engineers and shaping architectural standards in a fully r...
4 days ago
$150K - $175K *
Lead the charge in transforming financial operations while ensuring compliance and accuracy. Collaborate with cross-functional teams to enhance processes, manage audits, and drive strategic initiative...
4 days ago
Senior Revenue Systems Administrator
$138K - $189K *
Join a team that's redefining revenue systems by optimizing Salesforce CPQ architecture. Leverage your expertise to design and implement advanced pricing solutions, ensuring seamless Quote-to-Cash pro...
4 days ago
Principal Technical Marketing Engineer | US | Remote
$183K - $220K *
Elevate technical storytelling by creating impactful demos and workshops that bridge the gap between product capabilities and customer understanding, empowering sales teams and enhancing buyer engagem...
4 days ago
Manager, Digital Marketing and HubSpot
$80K - $95K *
Unlock potential by managing HubSpot for impactful digital marketing campaigns. Collaborate with cross-functional teams to optimize lead flow, reporting, and website support, ensuring data integrity a...
4 days ago
Staff Software Development Engineer
$106K - $284K *
Reimagine healthcare technology by leading the development of secure, scalable microservices. Collaborate with cross-functional teams to enhance digital solutions that transform patient experiences an...
4 days ago
Senior Technical Lead, Enterprise Application Integrations
$119K - $150K *
Shape the future of enterprise application integrations by leading technical design and implementation for Finance, Accounting, and Supply Chain projects, collaborating with cross-functional teams to...
4 days ago
Placement Manager, Innovation & Small Business
$80K - $95K *
Champion client success by managing complex insurance placements, negotiating optimal coverage, and fostering key relationships in the insurance marketplace. Stay informed on industry trends to delive...
4 days ago
Dir, MAPS (Market Access Patient Services)/Medical Data Partnerships Lead
$185K - $344K *
Join a team that's redefining market access through innovative data partnerships. Lead strategic collaborations, ensure data compliance, and drive insights that enhance decision-making and patient ser...
Reposted 4 days ago
Clinical Supply Chain Site Lead
$110K - $130K *
Champion the clinical supply chain for late-stage oncology trials, ensuring seamless operations and communication between sites, suppliers, and stakeholders. Drive continuous improvement and complianc...
4 days ago
Financial Planning & Analysis Analyst
$105K - $130K *
Analyze financial performance and drive insights to enhance profitability. Collaborate with cross-functional teams to develop budgets, forecasts, and reports, ensuring consistent financial processes a...
4 days ago
Manager, Nonsterile Production Planning
$110K - $130K *
Transform production planning by leading a dynamic team to optimize non-sterile compounded production. Drive strategic planning, manage capacity, and ensure alignment with demand forecasts while foste...
4 days ago
Lead Software Engineer - Full Stack (.NET / Angular/ Microservices)
$125K - $188K *
Empower a high-performing tech team by leading the development of scalable web applications. Drive project delivery, mentor developers, and ensure compliance in a dynamic, regulated environment while...
Reposted 4 days ago
Sales Director- Regional Enterprise Expansion
$124K - $165K *
Drive revenue growth as a key leader guiding a dynamic sales team focused on optimizing customer relationships and expanding market reach through strategic cross-selling initiatives and innovative sal...
Reposted 4 days ago
Frontend Engineer - Design Systems
$140K - $158K *
Partner with us to enhance design systems by building shared components and patterns. Collaborate with designers and engineers to create accessible, user-friendly interfaces that elevate product exper...
4 days ago
Enterprise Account Executive, KS/MO
$300K - $350K *
Pioneer sales growth in the cybersecurity sector by acquiring new accounts, nurturing relationships, and exceeding quotas. Leverage your expertise in disruptive solutions and channel partnerships to d...
4 days ago
$110K - $130K *
Lead the charge in establishing a standardized implementation methodology, overseeing complex projects from contract to go-live. Drive team adoption, manage dependencies, and ensure successful transit...
4 days ago
Registered Nurse (RN) | Pre-Post Operative
$67K - $100K *
Oversee comprehensive nursing care by developing tailored care plans, providing emotional support, and collaborating with healthcare teams to ensure optimal patient outcomes and safety in a dynamic cl...
4 days ago
Senior Workforce Experience Consulting Manager
$150K - $180K *
Transform your career by leading strategic workforce enablement initiatives. As a Senior Manager, you'll collaborate with senior executives, shape learning strategies, and drive impactful change acros...
4 days ago
Workforce Experience Consulting Manager - Learning and Development
$120K - $145K *
Drive impactful organizational transformation by leading complex client engagements, integrating learning and enablement strategies. Collaborate with multidisciplinary teams to enhance workforce capab...
4 days ago
Senior Customer Success Engineer, Audit
$110K - $130K *
Empower audit teams to excel with a hands-on role that drives software adoption, enhances workflow efficiency, and delivers measurable outcomes. Collaborate across functions to modernize audit practic...
Reposted 4 days ago
$110K - $120K *
Join a team that's dedicated to optimizing sales solutions through technical expertise. Collaborate with cross-functional teams to develop proposals, evaluate technologies, and manage multiple project...
4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.