Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$175K - $195K *

Shape the future of global HR operations by enhancing systems and processes for a seamless employee lifecycle. Collaborate cross-functionally to improve workflows, compliance, and service effectivenes...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $243K *

Join a team that's dedicated to managing commercial banking relationships, focusing on Mortgage Servicing Rights and Warehouse Lending. Drive revenue growth while ensuring compliance and fostering str...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $145K *

Join a dynamic team to ensure seamless network connectivity for dock deployments. Collaborate with IT teams, troubleshoot connectivity issues, and enhance customer confidence through effective communi...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$168K - $285K *

Elevate the future of software planning by leading a team that integrates human and AI collaboration. Shape product direction, connect work to business priorities, and drive strategic decisions in a d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining cloud reliability by enhancing observability, automation, and operational excellence. Collaborate across departments to ensure seamless deployment and management of SaaS...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform your legal career by providing strategic counsel across diverse business areas. Collaborate with a dynamic team while independently navigating complex legal matters, ensuring compliance, and...

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$67K - $100K *

Elevate patient care by developing nursing diagnoses, coordinating interventions, and providing comprehensive support to patients and families. Collaborate with healthcare teams to ensure optimal heal...

Today

  •   Less than 5 years exp.  •   Healthcare

$120K - $155K *

Contribute to Oracle database modernization by assessing, planning, and executing migration strategies. Collaborate with technical teams to optimize performance and ensure successful data migration in...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Drive data-driven decision-making by transforming complex data into actionable insights. Collaborate with cross-functional teams to enhance reporting and analytics using advanced SQL and AI tools, ens...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$174K - $215K *

Lead a dynamic team to drive business performance in hematology/oncology, focusing on metastatic breast cancer. Develop strategies for patient access and treatment, ensuring compliance and collaborati...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$66K - $169K *

Lead product quality initiatives to ensure compliance and continuous improvement throughout the product lifecycle, partnering with cross-functional teams to enhance manufacturing performance and suppo...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $245K *

Empower the oncology portfolio strategy by driving regional marketing initiatives, fostering KOL relationships, and executing launch tactics to optimize product adoption and customer engagement across...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $160K *

Drive the development of critical enterprise applications for DoD personnel, enhancing program and financial management capabilities. Collaborate within a product team to modernize technology and deli...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$100K - $140K *

Champion the proposal process by leading submissions, coordinating resources, and ensuring strategic alignment. Drive improvements in proposal development while fostering collaboration across teams to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$162K - $194K *

Drive growth as a Senior Product Marketing Manager, shaping messaging and campaigns for Observability products. Collaborate with cross-functional teams to enhance customer engagement and retention thr...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$122K - $183K *

Transform the aerospace certification landscape by leading process development, ensuring compliance with DO-178C standards, and collaborating with cross-functional teams to deliver high-quality softwa...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by managing Salesforce CRM implementations and configurations. Collaborate with teams to enhance user experience and ensure compliance with cybersecurity policies while providing exce...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Aerospace & Defense

$46K - $122K *

Lead the charge in implementing health insurance projects by collaborating with teams, analyzing client needs, and ensuring successful onboarding. Foster relationships and provide mentorship to drive...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Accelerate your career by driving operational excellence and strategic improvements. Collaborate with leadership and cross-functional teams to enhance customer experiences and optimize processes in a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K *

Analyze and enhance cost accounting practices across manufacturing operations, leveraging Oracle ERP expertise to drive process improvements and financial insights. Collaborate with cross-functional t...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$152K - $254K *

Shape the future of behavioral health by leading clinical programs, driving strategic initiatives, and fostering cross-functional partnerships to enhance member outcomes and operational excellence...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Champion data-driven decision-making by bridging clinical operations and analytics. Lead projects, deliver actionable insights, and enhance performance across clinics while managing stakeholder commun...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$75K - $109K *

Advance the future of Building Information Modeling by leading BIM strategies, ensuring model quality, and mentoring teams. Drive innovation through technology initiatives and enhance project delivery...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$60K - $125K *

Empower customer success by managing relationships and driving growth through strategic account management, ensuring satisfaction and advancing CloudWave as a trusted IT advisor in healthcare solution...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Champion life underwriting transformation initiatives by analyzing requirements, facilitating project lifecycles, and collaborating with cross-functional teams to enhance operational excellence and im...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.