Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Data Center Operations System Engineer - Plano, TX
$100K - $120K *
Collaborate with cross-functional teams to ensure optimal data center operations, managing infrastructure setup, troubleshooting, and documentation while maintaining high standards for deployment and...
3 days ago
$122K - $176K *
Drive impactful threat intelligence by synthesizing complex data into actionable insights. Collaborate across teams to create tailored intelligence products that enhance security understanding and sup...
3 days ago
$118K - $174K *
Drive successful project outcomes by leading cross-functional teams and managing large-scale ERP and SAP projects. Collaborate with stakeholders to align on objectives and implement effective change s...
Reposted 3 days ago
$128K - $250K *
Champion the development of winning strategies for complex public sector opportunities, engaging directly with customers and stakeholders to shape solutions and lead major pursuits from identification...
3 days ago
$80K - $95K *
Transform the Funding Department by leading a dedicated team, ensuring compliance with policies, optimizing processes, and fostering professional development to achieve high-quality funding approvals...
3 days ago
$100K - $120K *
Empower healthcare organizations by driving sales of innovative Nurse Call solutions. Own the full sales cycle, engage with senior leaders, and leverage your expertise to navigate complex deals in a d...
3 days ago
Platform Engineer (ServiceNow)
$110K - $130K *
Pioneer the administration and development of core business systems, focusing on ServiceNow. Collaborate with cross-functional teams to create scalable solutions that enhance operations, service, and...
Reposted 3 days ago
$150K - $180K *
Empower your career by leading innovative GTM engineering initiatives. Drive AI workflows, automate marketing processes, and enhance productivity across teams. Collaborate with stakeholders to transfo...
3 days ago
$150K - $180K *
Drive enterprise pipeline growth by leading integrated campaigns and demand generation strategies. Collaborate with cross-functional teams to optimize sales processes and build a high-performing marke...
3 days ago
$95K - $115K *
Accelerate progress at the intersection of marketing and data analytics. As a key player, you'll build reporting functions, define KPIs, and drive insights that empower teams across the organization t...
3 days ago
Project Manager II (Public Safety Software) - Remote
$80K - $95K *
Lead the planning and execution of Public Safety projects, ensuring timely delivery and effective collaboration across teams. Drive process improvements and maintain client relationships to enhance pr...
Reposted 3 days ago
Global Scientific Evidence Manager, Restorative Procedures
$143K - $196K *
Lead global evidence strategy and drive scientific engagement while collaborating cross-functionally to identify evidence gaps and shape priorities in clinical, R&D, and marketing teams. Make a signif...
3 days ago
$100K - $120K *
Transform the marketing landscape by leading growth initiatives, building campaigns, and leveraging data to drive qualified pipeline. Collaborate with cross-functional teams to activate strategies and...
3 days ago
Director, Commercial CMC Programs
$150K - $180K *
Empower the execution of CMC strategies by collaborating across teams to enhance production, streamline operations, and drive commercial success for innovative therapeutics and diagnostics, ensuring a...
Reposted 3 days ago
$150K - $200K *
Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...
3 days ago
Executive Director, Clinical Operations
$285K - $310K *
Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...
3 days ago
Staff Software Engineer, Partner Integrations
$229K - $260K *
Transform the integration landscape by architecting robust connections between NodeZero and key security platforms, ensuring reliability and observability while mentoring engineers and driving technic...
3 days ago
$95K - $115K *
Engineer customer reliability by providing expert technical support for IoT solutions. Collaborate with teams to resolve issues, enhance documentation, and gather feedback, ensuring a seamless custome...
3 days ago
$94K - $164K *
Champion cost reporting processes by ensuring data accuracy, preparing detailed reports, and analyzing financial information. Collaborate across departments to enhance reporting systems and support st...
3 days ago
$113K - $197K *
Lead regulatory and compliance oversight for Operations, ensuring accuracy and efficiency. Collaborate with enterprise partners to enhance operational processes, implement automation, and drive contin...
3 days ago
$94K - $164K *
Champion technical delivery and governance for enterprise release management, ensuring reliable software deployment and continuous improvement across teams while driving AI adoption and enhancing oper...
3 days ago
$72K - $115K *
Partner with us to design and validate predictive models that enhance business processes across various domains, leveraging data science techniques to drive insights and improve decision-making within...
3 days ago
Territory Sales Representative
$81K - $121K *
Transform retail partnerships by coaching top sellers, driving sales growth, and executing strategic plans to enhance agricultural product adoption and profitability in a dynamic, remote environment...
3 days ago
$136K - $253K *
Elevate your career by leading sales strategies and fostering dealer relationships to achieve market share goals. Drive team success through effective communication and innovative sales tools while ma...
3 days ago
$86K - $137K *
Optimize project outcomes as you manage small to medium-sized initiatives. Collaborate across teams, navigate risks, and ensure timely delivery of quality solutions while enhancing communication and s...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.