Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$105K - $110K *

Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in managing clinical operations for dialysis services, ensuring quality patient care, compliance, and operational efficiency across multiple facilities while fostering strong relations...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Lead the operations of a Special Investigations Unit, managing a team of investigators to enhance fraud detection and prevention. Drive compliance, collaborate with stakeholders, and shape strategies...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock insights by leading advanced data analytics for federal programs. Collaborate with cross-functional teams to ensure compliance and data integrity while mentoring junior analysts and presenting...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Lead EHS initiatives across multiple facilities, ensuring compliance and fostering a safety culture. Drive strategic planning, conduct inspections, and collaborate with teams to enhance environmental...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

$142K - $227K *

Unlock potential by leading the Escalations team to enhance customer resolution processes, drive quality outcomes, and collaborate across departments to address complex issues while fostering team gro...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $240K *

Advance expertise in energy markets by managing complex client engagements, developing strategic recommendations, and fostering client relationships. Utilize analytical skills to drive impactful solut...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$103K - $181K *

Optimize document control processes by leading the Information Branch, ensuring accurate and accessible records management for a major industrial program while coordinating with various stakeholders a...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $154K *

Optimize document management processes for a large-scale industrial project, ensuring accurate, secure, and accessible records throughout all project phases. Collaborate with multidisciplinary teams t...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock potential by leading a global accounting team, driving process improvements, and integrating AI solutions to enhance financial operations and reporting accuracy in a dynamic SaaS environment...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $250K *

Transform healthcare technology engagements by leading multidisciplinary teams, developing actionable strategies, and implementing AI and automation solutions to enhance operational efficiency and cli...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$240K - $300K *

Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Grow your career with a leading RIA by transitioning your client base to a sophisticated platform. Leverage a collaborative team model to deliver comprehensive wealth management solutions for high-net...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Lead the charge in implementing the Deacom ERP platform, driving customer success through expert consultation, project management, and tailored solutions. Collaborate with clients to enhance business...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$78K - $92K *

Engage in impactful virtual counseling for patients with acute mental health conditions. Develop treatment plans, exercise clinical judgment, and collaborate with multidisciplinary teams to enhance be...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$120K - $130K *

Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$85K - $105K *

Transform client relationships by driving growth through consultative sales, managing complex opportunities, and collaborating with internal teams to exceed targets and deliver tailored solutions in a...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Transform the accounting function by overseeing monthly closes, ensuring compliance, and managing tax processes. Collaborate with finance leadership to drive accurate reporting and support strategic p...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$95K - $100K *

Transform virtual learning by leading strategy and development of innovative programs. Collaborate across teams to enhance educational experiences, ensuring quality and scalability while meeting diver...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $140K *

Join a team that's dedicated to transforming supply chain solutions through innovative Oracle OTM and GTM implementations, ensuring timely delivery and optimal client satisfaction while enhancing your...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Transportation

$121K - $145K *

Strategize financial operations and enhance reporting accuracy while leading the finance team. Collaborate with senior leadership to drive financial sustainability and operational efficiency across bu...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$140K - $160K *

Drive the development of critical enterprise applications for defense personnel, utilizing Java, Spring Boot, and Angular. Collaborate in an agile team to enhance program and financial management tool...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Champion revenue growth by leading proposal operations and capture strategies. Drive compliance and execution across multiple concurrent pursuits while building scalable infrastructure to enhance mark...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Business Services

$88K - $132K *

Help us drive growth as a strategic Channel Account Manager, collaborating with partners to create scalable sales strategies, enhance engagement, and achieve measurable outcomes in the enterprise tech...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.