Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$200K - $250K *

Unlock your potential as you drive growth by building relationships and creating strategies to engage mid-market accounts, ensuring success through effective sales execution and collaboration with cro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$154K - $185K *

Drive your career with a Senior Software Engineer role focused on evolving backend architecture and enhancing user experiences through innovative session replay solutions. Collaborate across teams to...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Transform product strategy by leveraging market insights and customer feedback to drive profitable sales growth, manage supplier performance, and enhance inventory productivity while developing a comp...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $135K *

Join a team that's shaping innovative EPM solutions. Utilize your expertise to implement planning and performance management tools integrated with NetSuite, driving successful project outcomes through...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $200K *

Optimize large-scale AI data center deployments by architecting rack-level compute solutions. Collaborate with cross-functional teams to ensure seamless integration of compute, storage, and networking...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$133K - $225K *

Unlock potential by leading a high-performing accounting team, overseeing statutory reporting across international entities, and ensuring accurate financial management while driving process optimizati...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$125K - $150K *

Engage with global partners to drive Professional Services growth, develop co-sell strategies, and enhance customer success through strategic alliances and measurable outcomes in a dynamic, collaborat...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$88K - $145K *

Join our dynamic sales team to drive results through effective outreach, pipeline management, and collaboration. Embrace a fast-paced environment where your contributions directly impact success and g...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Drive the success of our Entertainment touring portfolio by overseeing day-to-day operations, ensuring effective communication among stakeholders, and enhancing revenue opportunities throughout the co...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$144K - $209K *

Drive product innovation by collaborating with design and engineering teams, mentoring peers, and enhancing front-end strategies to create inclusive experiences that engage and delight users...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$125K - $150K *

Lead and execute multi-year account strategies for key enterprise accounts, driving revenue and fostering C-suite engagement in complex security environments. Leverage channel partnerships to enhance...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $175K *

Transform IT operations by establishing automated, self-service systems while ensuring ISO compliance. As a crucial partner across functions, you'll enhance security protocols, streamline workflows, a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$230K - $275K *

Optimize high-stakes negotiations and partnerships by leading complex enterprise agreements, while collaborating with internal stakeholders to drive commercial success and ensure legal compliance in a...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$204K - $254K *

Engage as a key member of a high-growth team driving technical sales and solutions. Influence customer success through in-depth product knowledge and presentations, while collaborating closely with Sa...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$182K - $226K *

Join a team that's driving innovation in a high-growth startup, engaging customers and providing technical expertise. Elevate your career by solving challenges and enhancing product experiences in a c...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$320K - $340K *

Drive growth by identifying and expanding opportunities within existing accounts, managing the sales process, and cultivating relationships in a consultative manner. Your expertise in technology sales...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$165K - $175K *

Lead compliance initiatives by analyzing tax regulations, delivering SAP solutions, and ensuring global client adherence to shifting legislative requirements. Your expertise will drive successful ERP...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Engage with a talented team to drive growth and innovation in pharma sales. Own the sales cycle from strategic prospecting to closing high-impact deals, while developing key relationships that enhance...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$163K - $224K *

Advance innovative backend systems for a cutting-edge experimentation platform, driving impactful decisions through large-scale data solutions in a collaborative team environment, while designing and...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$214K - $295K *

Pioneer the development of innovative user experiences across platforms, harnessing deep technical expertise and leadership to enhance product design. Collaborate broadly to drive operational excellen...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$79K - $148K *

Join a team that's dedicated to transforming complex economic data into actionable insights. As an Economics Specialist, you'll support macroeconomic research and analysis, collaborating with senior e...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$93K - $140K *

Pioneer a strategic role in employee relations, providing expert guidance and support across California. Collaborate with leaders to navigate complex workplace issues while driving compliance and fost...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$106K - $147K *

Champion the development of ML pipelines, ensuring scalable, reliable decision-making systems that optimize member outcomes while collaborating with cross-functional teams to enhance platform performa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$106K - $147K *

Lead the charge in developing and maintaining a robust rules engine for a critical platform. Collaborate with cross-functional teams to ensure compliance and performance standards while advancing your...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$106K - $147K *

Transform the member experience by delivering innovative full stack solutions using React, Node.js, PostgreSQL, and Kafka. Collaborate with cross-functional teams to create intuitive, scalable applica...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.