Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$167K - $183K *

Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$106K - $284K *

Lead application development initiatives, ensuring quality standards in healthcare IT. Collaborate with diverse teams to define requirements and implement solutions that profoundly impact patient care...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K *

Drive the future of implementation management by leading high-volume projects for fire and EMS agencies, executing end-to-end configurations and transitions, ensuring agencies utilize their purchased...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$167K - $229K *

Lead the charge in transforming clinical decision-making strategies within health insurance, ensuring compliance and quality in medical reviews while advancing innovation in medical management and cro...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$235K - $285K *

Advance your career by leading machine learning innovations that enhance autonomous vehicle localization. Architect cutting-edge solutions for real-time mapping and state estimation, ensuring safety a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$182K - $263K *

Drive simulation operations by leading a hybrid team to execute high-quality tests, establish evaluation metrics, and enhance processes using AI for improved operational performance across virtual tes...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$200K - $322K *

Lead the charge in driving open source adoption and governance. Manage community infrastructure, contributor pathways, and post-launch plans to ensure sustainable project growth and engagement across...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$184K - $356K *

Drive the development and automation of reliable, scalable AI services across diverse cloud environments, ensuring optimal performance and operational safety for production workloads and distributed s...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$124K - $195K *

Empower progress at the forefront of AI Compute by deploying and managing cutting-edge infrastructure. Collaborate with customers and internal teams to implement large-scale projects, ensuring optimal...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Join a team that's dedicated to providing advanced nursing care for patients with neurological conditions. Collaborate with specialists to assess, diagnose, and manage treatment plans while supporting...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Unlock potential by collaborating across teams to drive data integrity and safety in oncology clinical studies while developing comprehensive medical review plans and managing project deliverables...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$176K - $242K *

Join a team that's advancing AI in cybersecurity by building innovative reinforcement learning environments. You'll design infrastructure to transform vulnerability research into scalable training sol...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$83K - $222K *

Innovate your career with a Senior Epic Analyst role focused on designing and optimizing Epic solutions for population health and care coordination, while mentoring junior analysts and collaborating w...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $122K *

Join a team that crafts innovative commerce and digital strategies for premium clients across various major retail platforms, enhancing their market performance and driving impactful results through c...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$220K - $270K *

Shape the future of mapping technology by leading the design and deployment of advanced ML models. Drive innovation and cross-functional collaboration to ensure seamless integration and high-performan...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$220K - $270K *

Join a team that's pushing the boundaries of machine learning in autonomous vehicles. Enhance driving capabilities, lead innovative teams, and drive commercial-scale solutions with cutting-edge techno...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$87K - $157K *

Elevate your career by supporting the FAA's innovative Radar Surveillance Replacement initiative. Collaborate with teams at critical airports, ensuring seamless installation and implementation while l...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$350K - $430K *

Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K *

Inspire a data-driven customer support team, overseeing daily operations, coaching agents, and driving performance metrics to enhance service quality and team development in a transformative support e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$235K - $275K *

Advance your career by driving perception innovation in autonomous systems. Lead a team focusing on scene detection, environmental robustness, and scalable architectures. Collaborate on cutting-edge t...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$250K - $300K *

Join a dedicated team to provide comprehensive medical care, ensuring patient safety and health education while collaborating with healthcare professionals to enhance patient outcomes and maintain hig...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $195K *

Join a dynamic team as you cultivate investor relationships and drive capital growth. Leverage your LIHTC expertise to expand our investor base, manage key accounts, and contribute to impactful afford...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $95K *

Champion the analysis of Low-Income Housing Tax Credit projects, leveraging strong financial acumen to prepare investment models and reports. Collaborate with developers and manage multiple assignment...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$199K - $370K *

Optimize your sales expertise by driving revenue in state government sectors. Leverage your knowledge of procurement processes to build relationships and close deals, while collaborating with a top-ti...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$199K - $370K *

Engage with high-value government accounts nationwide, driving sales of industry-leading cloud solutions. Leverage your expertise in government procurement to build relationships, exceed quotas, and c...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.