Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Business Systems Architect
$167K - $183K *
Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...
2 weeks ago
Senior Manager Application Development
$106K - $284K *
Lead application development initiatives, ensuring quality standards in healthcare IT. Collaborate with diverse teams to define requirements and implement solutions that profoundly impact patient care...
Reposted 2 weeks ago
Implementation Manager, Essentials
$85K *
Drive the future of implementation management by leading high-volume projects for fire and EMS agencies, executing end-to-end configurations and transitions, ensuring agencies utilize their purchased...
Reposted 2 weeks ago
$167K - $229K *
Lead the charge in transforming clinical decision-making strategies within health insurance, ensuring compliance and quality in medical reviews while advancing innovation in medical management and cro...
Reposted 2 weeks ago
Lead Machine Learning Engineer - Localization
$235K - $285K *
Advance your career by leading machine learning innovations that enhance autonomous vehicle localization. Architect cutting-edge solutions for real-time mapping and state estimation, ensuring safety a...
Reposted 2 weeks ago
Manager, Simulation Operations
$182K - $263K *
Drive simulation operations by leading a hybrid team to execute high-quality tests, establish evaluation metrics, and enhance processes using AI for improved operational performance across virtual tes...
Reposted 2 weeks ago
Growth Engineer, Developer Platform
$200K - $322K *
Lead the charge in driving open source adoption and governance. Manage community infrastructure, contributor pathways, and post-launch plans to ensure sustainable project growth and engagement across...
2 weeks ago
Senior Production Engineer - DGX Cloud
$184K - $356K *
Drive the development and automation of reliable, scalable AI services across diverse cloud environments, ensuring optimal performance and operational safety for production workloads and distributed s...
2 weeks ago
$124K - $195K *
Empower progress at the forefront of AI Compute by deploying and managing cutting-edge infrastructure. Collaborate with customers and internal teams to implement large-scale projects, ensuring optimal...
2 weeks ago
APP - Nurse Practitioner or Physician Assistant | Neurology
$90K - $110K *
Join a team that's dedicated to providing advanced nursing care for patients with neurological conditions. Collaborate with specialists to assess, diagnose, and manage treatment plans while supporting...
2 weeks ago
$100K - $120K *
Unlock potential by collaborating across teams to drive data integrity and safety in oncology clinical studies while developing comprehensive medical review plans and managing project deliverables...
Reposted 2 weeks ago
Reinforcement Learning Engineer
$176K - $242K *
Join a team that's advancing AI in cybersecurity by building innovative reinforcement learning environments. You'll design infrastructure to transform vulnerability research into scalable training sol...
Reposted 2 weeks ago
Senior Epic Analyst-Healthy Planet - Care Coordination
$83K - $222K *
Innovate your career with a Senior Epic Analyst role focused on designing and optimizing Epic solutions for population health and care coordination, while mentoring junior analysts and collaborating w...
Reposted 2 weeks ago
Supervisor, Commerce Strategy & Client Partnerships
$102K - $122K *
Join a team that crafts innovative commerce and digital strategies for premium clients across various major retail platforms, enhancing their market performance and driving impactful results through c...
Reposted 2 weeks ago
Lead ML Engineer - Lane & Route Network Mapping
$220K - $270K *
Shape the future of mapping technology by leading the design and deployment of advanced ML models. Drive innovation and cross-functional collaboration to ensure seamless integration and high-performan...
Reposted 2 weeks ago
Lead Machine Learning Engineer
$220K - $270K *
Join a team that's pushing the boundaries of machine learning in autonomous vehicles. Enhance driving capabilities, lead innovative teams, and drive commercial-scale solutions with cutting-edge techno...
Reposted 2 weeks ago
$87K - $157K *
Elevate your career by supporting the FAA's innovative Radar Surveillance Replacement initiative. Collaborate with teams at critical airports, ensuring seamless installation and implementation while l...
2 weeks ago
Vice President, Clinical Development
$350K - $430K *
Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...
Reposted 2 weeks ago
$100K *
Inspire a data-driven customer support team, overseeing daily operations, coaching agents, and driving performance metrics to enhance service quality and team development in a transformative support e...
Reposted 2 weeks ago
$235K - $275K *
Advance your career by driving perception innovation in autonomous systems. Lead a team focusing on scene detection, environmental robustness, and scalable architectures. Collaborate on cutting-edge t...
Reposted 2 weeks ago
Physician | Radiation Oncologist
$250K - $300K *
Join a dedicated team to provide comprehensive medical care, ensuring patient safety and health education while collaborating with healthcare professionals to enhance patient outcomes and maintain hig...
2 weeks ago
Capital Originations, Director
$150K - $195K *
Join a dynamic team as you cultivate investor relationships and drive capital growth. Leverage your LIHTC expertise to expand our investor base, manage key accounts, and contribute to impactful afford...
2 weeks ago
$90K - $95K *
Champion the analysis of Low-Income Housing Tax Credit projects, leveraging strong financial acumen to prepare investment models and reports. Collaborate with developers and manage multiple assignment...
2 weeks ago
Senior Sales Specialist – Government Risk State Business
$199K - $370K *
Optimize your sales expertise by driving revenue in state government sectors. Leverage your knowledge of procurement processes to build relationships and close deals, while collaborating with a top-ti...
2 weeks ago
Nationwide Government Sales Specialist – High Value Accounts
$199K - $370K *
Engage with high-value government accounts nationwide, driving sales of industry-leading cloud solutions. Leverage your expertise in government procurement to build relationships, exceed quotas, and c...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.