Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Global Trade Compliance Manager
$110K - $130K *
Shape global trade compliance strategies by overseeing export controls, sanctions, and customs regulations. Lead initiatives to ensure adherence to laws while advising leadership on complex transactio...
2 weeks ago
$190K - $210K *
Join a team that's redefining global tax leadership, overseeing compliance and strategy across multiple regions. Leverage your expertise to drive efficiency and collaboration in a dynamic multinationa...
2 weeks ago
Director, Strategic Business Development
$150K - $180K *
Drive sustained growth as a key commercial leader by executing innovative revenue strategies, generating new client opportunities, and expanding market presence in the evolving data center and AI infr...
Reposted 2 weeks ago
Dental Policy & Quality Manager
$93K - $132K *
Lead the charge in developing and maintaining dental coverage policies, ensuring clinical integrity and compliance. Collaborate across teams to enhance program infrastructure and support regulatory au...
2 weeks ago
Revenue Accounting Transformation Manager
$100K - $125K *
Transform revenue accounting by leading automation and scalability initiatives across the Quote-to-Cash lifecycle, ensuring compliance with ASC 606 while enhancing operational efficiency and data inte...
2 weeks ago
Technical Program Manager, Money-as-a-Service
$135K - $160K *
Champion the delivery of large-scale technical programs by leading cross-functional teams, enhancing communication and operational efficiency, and driving strategic decisions to empower users and tack...
Reposted 2 weeks ago
$190K - $225K *
Drive revenue growth as a leader in measurement sales, managing a team of sales directors. Leverage existing relationships to retain clients and generate new business while fostering a high-performanc...
2 weeks ago
Workday Associate Engagement Manager
$80K - $95K *
Support project delivery as an Associate Engagement Manager, collaborating with teams on Workday implementations and ensuring customer satisfaction while driving innovation and strategic growth in the...
2 weeks ago
Head of Specialty Therapeutics
$252K - $315K *
Drive innovation in interventional psychiatry by developing evidence-based programs and protocols. Collaborate with clinical teams to enhance patient outcomes and ensure compliance with regulatory sta...
2 weeks ago
Field Marketing Manager (Remote - Central/Eastern Time Zone)
$100K - $155K *
Help us drive regional marketing initiatives that align with sales priorities, enhance pipeline growth, and execute impactful events. Collaborate across teams to deliver integrated campaigns and optim...
2 weeks ago
Senior InfoSec Risk & Compliance Specialist
$120K *
Help us modernize compliance operations by implementing continuous monitoring and automation for SOC 2, SOX, and PCI audits. Drive risk management and enhance efficiency while supporting a growing tea...
2 weeks ago
Senior Manager, Travel Services
$100K - $120K *
Accelerate progress at a dynamic travel support organization by leading diverse teams, enhancing operational processes, and ensuring exceptional customer satisfaction through proactive service and str...
2 weeks ago
$150K - $170K *
Lead and scale a high-performing sales team, driving revenue growth and execution. Collaborate cross-functionally to enhance go-to-market strategies while coaching and developing future sales leaders...
2 weeks ago
$130K - $160K *
Drive the development of LLM-based agents, ensuring robust production systems, effective evaluation, and seamless integration with company data while maintaining security and operational excellence ac...
2 weeks ago
Senior Gameplay Engineer - Game Modes
$160K - $240K *
Build innovative gameplay systems for an exciting new project, collaborating with a dedicated team to create engaging experiences. Drive technical excellence in C++ and Unreal Engine, ensuring seamles...
2 weeks ago
Enterprise Account Director, New Business (API/CPaaS)
$120K - $157K *
Shape the future of enterprise sales by driving innovative strategies, fostering relationships, and generating revenue through a proactive approach in a dynamic, remote environment focused on large mu...
2 weeks ago
$150K - $180K *
Champion customer success by leading a Technical Account Management team to enhance retention, drive adoption of our AI-powered platform, and ensure long-term growth through strategic client engagemen...
2 weeks ago
$100K - $120K *
Join a dynamic team to drive sales growth in the beauty sector, identifying new opportunities and fostering relationships with key retailers. Collaborate across departments to shape strategies that am...
Reposted 2 weeks ago
Lead Constructability Specialist
$111K - $150K *
Join a team that's advancing constructability practices across major projects. Lead the integration of strategies, mentor teams, and ensure consistent standards while driving continuous improvement in...
2 weeks ago
Senior Director, Patient Reported Outcomes
$222K - $292K *
Elevate patient outcomes by leading global evidence strategies that showcase the value of therapies. Collaborate across functions to drive research programs, influence decision-making, and ensure scie...
2 weeks ago
P&C Actuary Consultant II (Reserving)
$70K - $121K *
Help us drive impactful reserving strategies by leveraging actuarial expertise and analytical skills. Collaborate with management and partners to execute projects that enhance business goals through e...
2 weeks ago
$159K - $273K *
Lead the SEO strategy for multiple rental platforms, driving organic traffic growth through collaboration with cross-functional teams. Own performance metrics and prioritize initiatives to enhance mar...
2 weeks ago
$138K - $186K *
Unlock your potential as a principal technical leader for enterprise Unix and Linux platforms, driving architecture, automation, and lifecycle management to deliver resilient infrastructure for critic...
2 weeks ago
Financial Operations Analyst II, Treasury
$70K - $99K *
Unlock critical workflows in Financial Operations by leveraging AI, SQL, and Python to enhance efficiency and accuracy in money movement processes, while collaborating with diverse teams to drive proc...
Reposted 2 weeks ago
Vice President, Head of Construction
$160K - $200K *
Oversee the execution of multiple utility-scale solar and BESS projects, ensuring on-time, on-budget delivery while managing contractor performance and maintaining safety and quality standards across...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.