Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$125K - $140K *

Shape the future of ERP and Finance transformation by guiding clients through strategic assessments, technology alignment, and impactful change initiatives. Leverage your expertise to foster strong re...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $163K *

Shape the future of AI in our organization as a strategic leader driving enterprise-wide adoption and integration of AI technologies, enhancing productivity and delivering measurable results through i...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $150K *

Transform cloud infrastructure at scale while designing robust pipelines and practices. Oversee the integration of security, compliance, and operational standards to support enterprise-wide AI-driven...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$267K - $401K *

Lead the charge in defining product strategy and execution for Developer Experience and AI initiatives, ensuring secure interactions and impactful outcomes across technical domains while collaborating...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$67K - $100K *

Join a team that's dedicated to providing exceptional nursing care by assessing patient needs, developing care plans, and collaborating with healthcare professionals to enhance patient outcomes and su...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $130K *

Unlock your potential by providing expert SAP EWM support, resolving complex issues, and enhancing system performance. Collaborate with teams, mentor junior consultants, and drive improvements to ensu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Create seamless user experiences by developing robust APIs and integrating third-party software. Collaborate with teams to design systems that prioritize performance and maintainability while tackling...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$181K - $225K *

Lead the charge in operationalizing complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development and manage global lab relationships, ensuring strategic...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $120K *

Transform the sales landscape by driving growth in Inorganic product lines. Engage with customers, manage accounts, and implement strategic business plans to enhance market share and profitability in...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$420K - $476K *

Elevate your career by driving Employer Sales growth, shaping go-to-market strategies, and building a high-performing sales organization. This strategic role requires strong leadership and expertise i...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$175K - $200K *

Drive impactful change in healthcare consulting by leveraging your expertise in clinical operations and research administration. Collaborate with executive leaders to solve complex challenges and fost...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Empower your career by bridging technical solutions and customer needs in the drive-thru technology space. Collaborate with Sales and Product teams to design and deliver innovative solutions that enha...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$86K - $138K *

Lead the strategy and execution of enterprise data exchange products, ensuring secure and standardized data sharing. Collaborate with stakeholders to drive interoperability and maximize business value...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $185K *

Join a team that's redefining tactical communications and networking strategies for unmanned systems. Leverage your expertise to shape connectivity solutions, ensuring seamless data exchange across jo...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$197K - $260K *

Transform customer experiences by leading technical discovery and designing innovative data solutions. Collaborate with sales and engineering teams to drive adoption and expansion of the dbt platform...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $175K *

Grow expertise in Operational Technology security, leading critical engagements across industrial systems. Collaborate on advanced methodologies while mentoring others and contributing to pivotal rese...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $175K *

Drive the development of innovative AI and data solutions, enhancing enterprise data platforms while ensuring scalable, quality delivery. Collaborate with teams to define technical architecture, shapi...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $176K *

Lead the charge in managing a high-performing PMO team, driving project success through strategic financial oversight, talent development, and cross-functional collaboration to enhance operational eff...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$82K - $123K *

Join a dynamic team to design, develop, and maintain robust integrations using Oracle SOA and WebMethods, enhancing operational performance and delivering high-quality solutions in a collaborative env...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$40K - $200K *

Join a dynamic team to drive business growth through consultative sales, building lasting client relationships, and delivering innovative payment solutions. This role offers uncapped earnings and oppo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$192K - $237K *

Shape the future of engineering communication by leading our technical content strategy. Collaborate with engineers to elevate their work, enhance public presence, and drive impactful narratives that...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$160K - $200K *

Lead the charge in shaping Stedi's litigation strategy, driving affirmative disputes and regulatory actions to protect and expand our operational freedom in the healthcare sector. Collaborate with lea...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$54K - $159K *

Champion proposal excellence by leading the development and delivery of high-quality RFP responses. Collaborate with cross-functional teams to ensure strategic alignment and competitive positioning, d...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$185K - $375K *

Shape the future of cloud, container, and AI security. Lead strategy, architecture, and a high-performing team to ensure secure enterprise platforms while balancing risk and engineering speed. Drive i...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the charge in driving complex sales within mid-market organizations, influencing hiring strategies and compliance. Own the full sales cycle, build strong pipelines, and engage with multiple stake...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.