Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$75K - $150K *

Elevate cybersecurity effectiveness by leading proactive Red Team operations that simulate real-world threats, from social engineering to physical security testing, ensuring clients are resilient agai...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$123K - $145K *

Unlock your potential as a strategic partner in business development, driving revenue through VARs and resellers. Collaborate with sales teams to enhance partner engagement and pipeline creation, ensu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $205K *

Transform the U.S. sales landscape by driving strategic account plans and fostering relationships in the kidney transplant sector, ensuring optimal product utilization and achieving revenue targets th...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform financial operations by leading accounting, reporting, and compliance efforts. Collaborate with teams to ensure integrity in financial data and support strategic growth initiatives while fos...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $152K *

Drive your career forward by owning SEO and AEO strategies that enhance visibility and engagement across organic channels. Collaborate with cross-functional teams to optimize content and technical per...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$195K - $225K *

Lead the charge in transforming client development through strategic operations and enablement. Drive growth initiatives, manage a high-performing team, and ensure seamless execution across programs t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$164K - $246K *

Unlock potential by driving customer transformation and success in strategic accounts. Leverage your leadership skills to enhance value across deployments, ensuring satisfaction and optimizing the ado...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$172K - $215K *

Lead and develop a national Solutions Engineering team, driving technical wins and ensuring effective deployment of drone technology in public safety. Collaborate with sales and product teams to enhan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$105K - $145K *

Collaborate with cross-functional teams to design integrated solutions that enhance user experience, leveraging AI tools and a design system to create cohesive workflows and drive product value in a B...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $115K *

Champion innovative solutions by managing complex general liability claims, ensuring effective resolution strategies while collaborating with diverse teams in a dynamic, flexible work environment...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Elevate your career by leading accounting operations in a dynamic FinTech environment. Drive financial accuracy, compliance, and team development while implementing innovative solutions to support rap...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $168K *

Lead the charge in federal grant management for the 988 Suicide & Crisis Lifeline, overseeing compliance, budgeting, and operations. Collaborate across teams to ensure effective grant administration a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$104K - $156K *

Transform air medical transport by leveraging your piloting expertise to ensure safe, efficient flights. Collaborate with a dedicated team while adhering to regulatory standards and operational protoc...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$195K - $244K *

Unlock your potential as a Global Regulatory Leader, driving regulatory strategy and submissions for CNS projects. Collaborate with cross-functional teams, mentor junior staff, and ensure compliance w...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $191K *

Lead product strategy and execution by driving cross-functional teams to deliver high-quality solutions. Own the product lifecycle, prioritize impactful features, and leverage customer insights to ali...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Lead digital content strategy to enhance audience engagement across platforms. Collaborate with newsrooms to optimize local content distribution and drive growth through innovative digital solutions a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$83K - $104K *

Elevate your nursing career by overseeing patient care and managing staff in a secure clinical setting. Lead compliance with healthcare standards, educate patients, and ensure safety through your expe...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$152K - $241K *

Engage with a dynamic team to enhance CUDA Tile, optimizing compiler transformations and performance for NVIDIA GPUs. Drive innovation in deep learning applications, defining APIs and implementing cut...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$140K - $190K *

Shape the future of customer projects by leading strategic SaaS implementations, ensuring exceptional execution and stakeholder engagement. As a key player, you'll drive project success through proact...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $170K *

Partner with us to drive growth and strengthen relationships with key strategic accounts. Leverage your expertise in enterprise sales to identify opportunities, ensure renewals, and deliver measurable...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $266K *

Champion MuleSoft implementations by developing clean code and guiding teams. Leverage expertise in Salesforce and API management to deliver enterprise-grade solutions while mentoring junior developer...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $155K *

Champion product strategy for a leading mobile game, driving growth through LiveOps. Lead a cross-functional team to enhance player engagement, retention, and monetization while balancing immediate pe...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$88K - $154K *

Drive security excellence by managing vulnerabilities, ensuring compliance, and maintaining system integrity. Collaborate with teams to remediate findings and uphold NIST standards in a hands-on techn...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$162K - $170K *

Drive advanced machine learning solutions as a key contributor to our perception team, focusing on deep learning and computer vision to enhance robotics technology and bring innovative models from ide...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $170K *

Join a team that's at the forefront of blockchain innovation, driving transformative solutions for financial services. Leverage your sales prowess to exceed quotas and foster strong client relationshi...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.