Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$172K - $202K *

Unlock innovative insights and strategies in procurement and supply chain leadership. Collaborate with executives to drive actionable solutions, analyze market trends, and enhance client engagement th...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$67K - $105K *

Join a dynamic team to manage client accounts, delivering trust and estate planning services while ensuring compliance and fostering strong client relationships. Drive financial strategies and collabo...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$215K - $235K *

Advance drug substance development and drive clinical readiness projects by leading process chemistry initiatives, collaborating with cross-functional teams, and ensuring regulatory compliance for suc...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$193K - $228K *

Join a dynamic team to lead complex, cross-functional programs, ensuring timely delivery of high-quality features while driving alignment across Product, Engineering, and Design teams in a fast-paced...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$148K - $225K *

Join a team that's transforming revenue operations through AI-driven insights. You'll collaborate with senior leaders, architect workflows, and drive adoption to ensure measurable business outcomes ac...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Champion a global partner marketing strategy that drives measurable revenue through collaboration with partners, sales, and marketing teams. Lead a distributed team to create impactful go-to-market pr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Empower customer success by driving engagement and satisfaction for automotive clients. Develop strategies to enhance product adoption, mitigate churn, and foster strong relationships, ensuring custom...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K *

Elevate sales performance by driving demand for portable ultrasound systems through strategic networking, cold calling, and consultative selling in a dynamic healthcare environment, while managing key...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Champion the vision and strategy for AI-powered products, driving their roadmap and delivery while mentoring peers. Leverage AI tools to enhance decision-making and product lifecycle management, ensur...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a team that's transforming gameplay experiences by designing immersive worlds and interactive features in Unreal Engine. Collaborate across disciplines to create engaging multiplayer environments...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$107K - $132K *

Join a team that's shaping the future of cloud services and authentication systems. As a key contributor, you'll design, build, and maintain scalable, secure solutions while collaborating with cross-f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$109K - $143K *

Unlock potential by managing creative operations for paid social campaigns. Collaborate with cross-functional teams to ensure timely delivery and high-quality creative that aligns with brand goals, dr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $230K *

Unlock potential by driving strategic sales initiatives for major clients. Engage in lead origination, account management, and growth strategies in the Retail and CPG sectors, leveraging industry insi...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Transform the GTM landscape by developing impactful enablement programs that enhance team productivity, streamline onboarding, and elevate customer experiences across the entire journey. Drive success...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$101K - $140K *

Join a dynamic team to drive client growth and retention by building trust-based relationships with C-Level Executives, ensuring they maximize value from services while identifying new opportunities f...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$180K - $212K *

Drive the end-to-end product experience for crypto-backed borrowing, defining innovative onchain credit solutions. Collaborate cross-functionally to ensure seamless, secure loan flows that empower cus...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$152K - $202K *

Drive patient access by leveraging your expertise in reimbursement and market access. Collaborate with healthcare providers to navigate complex payer landscapes, ensuring timely access to therapies wh...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$94K - $266K *

Unlock innovative AI solutions by leading technical designs and deployments across Agentforce and Salesforce. Collaborate with diverse teams to deliver impactful experiences and drive business value w...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$96K - $144K *

Accelerate progress at player acquisition and retention through hands-on management of paid media, promotions, and analytics. Leverage AI and APIs to drive growth while owning the player-growth P&L in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$214K - $308K *

Empower security excellence by leading high-performing teams, driving strategic initiatives, and collaborating across functions. Own major security programs and represent the organization to executive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Optimize client success by leading strategic relationships and enhancing revenue cycle performance. Drive measurable improvements, manage escalations, and ensure value realization across healthcare so...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $155K *

Join a team that's dedicated to enhancing customer success by leading a high-performing group of CSMs. Drive measurable value across a diverse portfolio, ensuring operational excellence and fostering...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$163K - $223K *

Shape the future of cloud security by bridging product innovation with U.S. Public Sector compliance. Leverage your expertise to translate complex regulations into actionable solutions, ensuring secur...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$212K - $265K *

Advance your career by leading the design of scalable insurance systems, collaborating with cross-functional teams to enhance product offerings and drive technical excellence in a dynamic environment...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$145K - $213K *

Shape the future of competitive intelligence by leading win/loss analysis, market insights, and strategic positioning. Collaborate with product marketing to ensure data-driven decisions that enhance o...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.