Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$110K - $130K *

Join a team that's dedicated to enhancing customer success through expert guidance in Privilege Access Management. Leverage your technical skills to support enterprise clients, ensuring seamless deplo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $200K *

Engage in leading a dynamic team dedicated to delivering top-notch offensive security engagements, ensuring delivery quality and client satisfaction, while collaborating with sales to expand accounts...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $225K *

Drive successful customer engagements by managing technical sales processes, designing enterprise-level solutions, and building strong relationships to close deals. Leverage your expertise to enhance...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$132K - $180K *

Drive impactful GTM systems strategy by optimizing processes and technology. Collaborate with cross-functional teams to enhance customer engineering workflows, ensuring alignment and continuous improv...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$70K - $116K *

Join a team that's dedicated to enhancing Long-Term Disability claims management. Leverage your expertise to guide professionals, analyze trends, and ensure high-quality outcomes while supporting a co...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$185K - $200K *

Champion robust backend architecture and distributed systems, guiding technical direction and establishing best practices. Collaborate across teams to build resilient, scalable applications and optimi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$117K - $137K *

Partner with us to build impactful relationships with state prison agencies, driving success through collaboration and innovative solutions. Your role will enhance liberty for justice-involved individ...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$201K *

Optimize your leadership skills in a dynamic role, guiding a skilled team of product managers and designers. Drive impactful product strategies that shape the future of justice and promote sustainable...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$250K - $280K *

Lead a dynamic product management team to shape innovative solutions in mental health care. Drive strategy, foster collaboration, and empower your team to deliver impactful products that enhance the t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $205K *

Accelerate progress at driving U.S. sales strategy for a new kidney transplant product. This role requires strategic account management, cross-functional collaboration, and a focus on building relatio...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Empower operational excellence across branches by enhancing capacity, driving consistency, and ensuring adherence to best practices. Collaborate with leadership to streamline processes and support str...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Drive operational excellence across branches by enhancing capacity, ensuring SOP compliance, and improving inventory integrity. Collaborate with leadership to support strategic initiatives and empower...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $190K *

Champion the transition of analytical methods from lab to manufacturing, ensuring the delivery of innovative neurological therapies through close collaboration across teams and management of external...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$79K - $93K *

Lead a dynamic team of Sales Support Administrators, driving sales support processes and ensuring compliance with BSI procedures. Collaborate with stakeholders to enhance team performance and deliver...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$93K - $116K *

Join a team that's redefining insurance underwriting by evaluating petroleum distribution applications, determining coverage levels, and ensuring compliance with industry standards. Leverage your expe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $300K *

Join a team that's driving corporate development initiatives, managing M&A processes, and collaborating with leadership to identify and execute strategic acquisitions that enhance growth and innovatio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$104K - $130K *

Engage with our engineering team to enhance your expertise in fire protection and plumbing design for commercial projects. Collaborate closely with project management, produce construction documents...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$209K - $250K *

Engineer scalable backend services and APIs to enhance our global marketplace. Collaborate with cross-functional teams, utilizing modern technologies like Go, Python, and Redis to deliver high-perform...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Help us secure our cloud-based healthcare platforms by designing and implementing robust security solutions. This role demands expertise in cloud security, AI/ML protection, and compliance with indust...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$242K - $275K *

Lead the charge in developing and deploying robust containerized software, manage CI/CD workflows, and grow a cohesive engineering team to enhance customer security operations and software delivery ac...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Manage and optimize Epic Professional Billing workflows, focusing on Claims and Remittance. Serve as a key resource for end-users, troubleshooting issues and enhancing billing processes to ensure accu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$164K - $262K *

Partner with us to navigate the complexities of mortgage regulation while supporting innovative product development. This role offers a unique opportunity to influence the legal landscape of consumer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $110K *

Join a team that's dedicated to delivering exceptional financial services. This role involves managing accounts payable, payroll, cash management, and month-end reconciliations while collaborating clo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $200K *

Lead the charge in shaping the technical strategy for cloud services, driving complex initiatives that enhance reliability, scalability, and security across multiple systems while collaborating with c...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Drive growth by hunting new logos and managing full-cycle enterprise deals across a 50-60-account territory. Collaborate with cross-functional teams to shape strategies and turn wins into repeatable m...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.