Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Product Manager, Scanning & Risk Data
$175K - $220K *
Optimize the product strategy for scanning and risk data, connecting technical systems with user needs. Drive improvements in data quality, usability, and scalability while collaborating across teams...
2 weeks ago
$80K - $100K *
Collaborate with cross-functional teams to implement and configure innovative solutions on a risk and compliance platform, ensuring customer success through expertise and effective communication in a...
Reposted 2 weeks ago
Regional Account Manager, Payor Accounts - West Coast
$140K - $185K *
Accelerate progress at the forefront of payor relations, leading a team to develop strategic partnerships that enhance patient access and optimize reimbursement for innovative medical technologies in...
2 weeks ago
Lead Compliance Risk Manager, Product Compliance - AI
$187K - $233K *
Support compliance for AI products by advising cross-functional teams, ensuring regulatory adherence, and shaping governance frameworks. Lead compliance initiatives, mentor colleagues, and drive produ...
2 weeks ago
Director, Global People Operations & Compliance
$152K - $259K *
Shape the future of global People Operations by leading a dynamic team to innovate and streamline processes, enhancing the employee experience through technology and strategic partnerships across func...
2 weeks ago
Assistant Professor, Physician Assistant
$110K - $159K *
Join us to foster an innovative educational environment, providing leadership and mentorship while enhancing curriculum and teaching methodologies to ensure student success and engagement in learning...
2 weeks ago
$108K - $130K *
Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...
2 weeks ago
Solutions Architect, Forward Deployed
$152K - $269K *
Explore the forefront of enterprise AI solutions by pioneering innovative architectures and prototypes that solve complex business problems. You will cultivate relationships, drive technical wins, and...
Reposted 2 weeks ago
$125K - $158K *
Lead technical discovery and pre-sales consultations, translating complex product capabilities into practical solutions. Collaborate with Sales to ensure prospects understand integration paths and pro...
2 weeks ago
Aftermarket Sales Professional
$80K - $100K *
Deliver tailored solutions and drive sales growth by leveraging your technical expertise and customer-first mindset. Collaborate with teams to maximize customer uptime and contribute to business succe...
2 weeks ago
Senior Case Manager RN - Oncology (Remote)
$79K - $127K *
Partner with us to deliver comprehensive case management services, ensuring quality care and optimal health outcomes for members with complex needs. Collaborate with healthcare teams to develop and im...
2 weeks ago
Senior Manager, Public Relations
$91K - $118K *
Join a dynamic team to lead public relations and media strategies, driving impactful campaigns and thought leadership. Collaborate with partners to amplify Kiva's mission and enhance its external pres...
2 weeks ago
Senior Software Engineer (Capture)
$130K - $170K *
Accelerate progress at the forefront of real-time media ingestion, designing and operating distributed services that enhance communication data processing for analytics and security. Lead projects and...
2 weeks ago
Director, Global Commodity Management- Remote
$150K - $180K *
Pioneer global commodity strategies and supplier relationships, driving cost, quality, and delivery outcomes. Lead and develop a team of Regional Commodity Managers to enhance supply continuity and co...
2 weeks ago
Senior Manager, Research and Technology Enablement
$120K - $145K *
Transform legal research by enabling AI adoption in law firms. Collaborate with leaders to design effective workflows, enhance vendor partnerships, and build internal AI capabilities, ensuring clients...
2 weeks ago
$100K - $120K *
Champion impactful People Projects by managing cross-functional initiatives, fostering collaboration, and driving measurable outcomes. Help shape the future of HR processes and project management in a...
2 weeks ago
Director Insights - TV & Streaming
$135K - $150K *
Empower clients by analyzing media investments and delivering actionable insights. Lead a team to enhance media effectiveness, ensuring operational excellence and collaboration across disciplines to d...
2 weeks ago
$167K - $196K *
Drive risk mitigation strategies by analyzing account takeover and scam threats. Collaborate cross-functionally to enhance user protection and platform integrity, shaping metrics and prevention tactic...
2 weeks ago
Senior Product Marketing Manager
$110K - $130K *
Drive the future of product marketing by shaping positioning, go-to-market strategies, and sales enablement. Collaborate with cross-functional teams to enhance customer education and competitive intel...
2 weeks ago
Senior Electrical Application Engineer
$125K - $160K *
Elevate your career by owning electrical application engineering for prefabricated platforms. Collaborate across disciplines to deliver scalable solutions, ensuring design integrity and execution read...
2 weeks ago
Senior Manager, Software Engineering
$180K - $240K *
Empower teams to innovate in residential construction software by leading high-performing engineering groups, fostering Agile practices, and enhancing project management for builders and homeowners al...
2 weeks ago
Residential Construction Inspection Specialist
$68K - $108K *
Drive the success of residential construction loans by overseeing inspections, ensuring compliance with guidelines, and facilitating communication between borrowers and builders throughout the project...
2 weeks ago
Senior Technical Program Manager
$133K - $235K *
Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...
2 weeks ago
Project Administration and Correspondence Lead
$74K - $130K *
Join a dynamic team to oversee project administration and correspondence management, ensuring effective communication and compliance. Support project policies and enhance documentation workflows to dr...
2 weeks ago
Regional Vice President | Full-Time | Remote
$180K - $210K *
Drive operational excellence across multiple hospitality venues, ensuring financial success and client satisfaction. Collaborate with GMs and corporate functions while leading business growth in a dyn...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.