Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$280K - $300K *

Lead the charge in driving new business growth by introducing innovative automation solutions to forward-thinking organizations, building lasting client relationships, and exceeding sales targets in a...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$139K - $222K *

Join a team that's shaping the future of housing market forecasting. Collaborate with experts to develop innovative models, extract key features, and communicate insights that drive strategic decision...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$231K - $363K *

Lead the charge in driving enterprise partnerships across the Southeast, focusing on selling an AI-powered care platform to enhance employer healthcare strategies and reduce costs while ensuring high...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Champion the long-term performance of a renewable energy portfolio by overseeing operations, optimizing revenue, and ensuring compliance. Lead third-party management and drive strategic initiatives to...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Energy & Utilities

$175K - $185K *

Lead high-performing software engineering teams to modernize customer-facing applications, enhance operational efficiency, and drive AI-enabled practices, ensuring alignment with business objectives a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$116K - $174K *

Join a team that's driving innovation in functional and technical solutions. Leverage your extensive experience to lead cross-functional teams, shape strategic goals, and enhance business processes th...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Drive customer success by managing enterprise accounts, ensuring adoption and satisfaction with cybersecurity solutions. Collaborate cross-functionally to deliver value and strategic alignment through...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $140K *

Champion project success by managing cross-functional initiatives, ensuring timely delivery of new products, packaging, and promotions. Collaborate with diverse teams to drive accountability and strea...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$135K - $160K *

Elevate our SaaS infrastructure by re-engineering core products for global scalability, optimizing routing latency, and enhancing monitoring systems. Collaborate with engineers to tackle operational c...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$154K - $193K *

Lead the design and implementation of Organizational Change Management strategies, delivering comprehensive training programs and materials to ensure effective adoption of enterprise systems across di...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$83K - $104K *

Engage top talent in the Life Sciences sector, driving R&D and commercial success. Collaborate with leaders to enhance candidate experiences while managing recruitment workflows and sensitive informat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Staffing

$225K - $250K *

Champion compliance and innovation as you navigate complex legal landscapes, supporting diverse teams in a fast-paced environment. Leverage your expertise to drive growth while managing legal risks ac...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$166K - $232K *

Lead the evolution of our data platform to enhance analytics and machine learning capabilities. Collaborate cross-functionally to architect robust data solutions that empower teams to leverage insight...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $185K *

Champion pricing strategy and lead a dynamic team to develop competitive, compliant pricing for complex U.S. Government opportunities, directly influencing organizational success and growth in federal...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $130K *

Drive the design and analysis of transportation structures, ensuring compliance with AASHTO standards while collaborating with multidisciplinary teams on projects across Colorado and Arizona...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$140K - $150K *

Reimagine data management as a Senior Technical Product Owner, leading cross-functional teams to drive product vision and execution. Oversee complex SQL Server systems and cloud-native applications, e...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$140K *

Unlock potential by leading a high-performing sales team in the public safety SaaS sector. Drive growth, execute strategic deals, and collaborate cross-functionally to enhance our market-leading softw...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $160K *

Elevate your career by joining a dynamic team as a Data Engineer, owning end-to-end data systems and driving platform modernization. You'll improve data reliability and work closely with cross-functio...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $175K *

Lead the charge in building trust through compliance frameworks, guiding customers and teams in navigating security and data protection. Engage directly with clients, translating complex compliance ne...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $200K *

Join us to investigate and resolve platform issues, ensuring quality across campaigns. Collaborate with cross-functional teams to enhance processes, automate checks, and maintain high standards in a f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$177K - $236K *

Shape the future of economic capital modeling by developing and enhancing internal analytics capabilities, collaborating across teams to drive data-driven business decisions and optimize capital alloc...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Transform enterprise strategies into actionable roadmaps, guiding clients through comprehensive change initiatives. Collaborate with stakeholders to drive alignment, enhance performance, and ensure su...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Empower Public Safety agencies by driving sales and fostering relationships across a multi-state territory. Manage the sales cycle through consultative partnerships, ensuring pipeline growth and reven...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$75K - $90K *

Lead the charge in driving sales growth by engaging independent physician practices. Utilize your expertise in full-cycle sales to build relationships, conduct virtual demos, and collaborate with team...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$240K - $260K *

Join a team that's dedicated to providing expert legal guidance in consumer loan servicing. Leverage your extensive experience to support compliance, risk management, and operational strategies while...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.