Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$130K - $160K *

Transform enterprise solutions as a Salesforce Solution Architect, leading teams to deliver innovative, scalable projects. Drive presales, guide architecture, and leverage cutting-edge AI capabilities...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$133K - $210K *

Lead the charge in shaping security operations by architecting SIEM, driving automation, and mentoring a dedicated team. Your expertise will enhance threat detection and incident response, ensuring ro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$217K - $303K *

Shape the future of community engagement by leading innovative product strategies that enhance user experiences and foster vibrant connections. Collaborate with cross-functional teams to drive impactf...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$194K - $272K *

Drive modernization efforts across complex infrastructure programs, collaborating with engineering teams to ensure successful execution and alignment with long-term strategies. Leverage technical expe...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$108K - $149K *

Lead project management initiatives within the MSSP business, driving product transitions and strategic programs. Collaborate cross-functionally to ensure timely delivery and quality outcomes while fo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $189K *

Elevate organizational efficiency by leading Workday Absence and Time Tracking solutions. Collaborate cross-functionally to optimize processes, ensuring compliance and enhancing user experience as the...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$244K - $305K *

Drive financial strategy and analysis for global commercialization efforts, partnering with cross-functional teams to enhance decision-making and support successful product launches in the biopharmace...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Lead the design and delivery of innovative Service Cloud Voice solutions, guiding clients through contact center modernization and AI adoption. Collaborate with teams to create scalable, secure archit...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $155K *

Champion product innovation by managing software initiatives that enhance internal communication and streamline operations. Collaborate with cross-functional teams to deliver impactful solutions and d...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Staffing

$120K - $150K *

Champion complex client relationships, driving multi-year growth through strategic partnerships and executive engagement. Lead cross-functional teams to deliver impactful solutions while mentoring pee...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Unlock potential by leading Medicare sales initiatives, managing key client relationships, and driving revenue growth through strategic partnerships and market insights. Ensure compliance and customer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $185K *

Shape strategic success for key accounts by leading market access initiatives, collaborating with cross-functional teams, and driving growth through innovative solutions and insights in the managed ma...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Transform healthcare delivery by leading clinical operations, ensuring high-quality patient care, and fostering collaboration across departments. Drive strategic initiatives while managing resources a...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $140K *

Drive efficiency and scalability in onboarding processes, enhancing customer experience through innovative strategies and data-driven leadership. Lead a high-performing team to optimize resources and...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$150K - $180K *

Champion innovative healthcare research by leading complex evaluations and business development initiatives, fostering collaboration among diverse experts to enhance Medicare and Medicaid services and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Drive the design and implementation of hydraulic systems, ensuring performance and reliability through analysis, testing, and collaboration with cross-functional teams in a dynamic engineering environ...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$84K - $121K *

Take ownership of our technical SEO program, ensuring optimal site health and structure. Lead audits, implement AI-driven workflows, and collaborate with cross-functional teams to enhance web performa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$94K - $155K *

Join a team that's dedicated to enhancing underwriting excellence through analytics and innovation. Lead a skilled group of underwriters, manage complex cases, and collaborate across teams to improve...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$250K - $300K *

Join a team that's redefining additive manufacturing by driving automated CAD-to-print workflows. Lead a multidisciplinary group to enhance production systems, ensuring quality and efficiency in aeros...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Shape the future of orthodontics by delivering exceptional care and innovative treatments. Join a dedicated team in a thriving practice, enhancing smiles and patient experiences across multiple locati...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a dynamic team where you'll drive strategic client engagement and foster relationships to open new service lines in the Consumer, Retail, and Logistics sector, leveraging your experience in sales...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$244K - $409K *

Drive the development of a global SME organization, leading regional teams to enhance technical selling and product direction. Transform ambiguity into structure while mentoring leaders and collaborat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $131K *

Accelerate progress at the intersection of technology and finance by leading SAP Central Finance initiatives. Engage with teams to deliver tailored solutions, ensuring compliance and enhancing client...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$157K - $283K *

Unlock your leadership potential as you drive innovative transportation projects in Ohio. Collaborate with stakeholders to enhance infrastructure, optimize project delivery, and lead a dynamic team to...

RemoteRemote

Reposted 2 weeks ago

  •   15+ years exp.  •   Real Estate & Construction

$100K - $185K *

Transform enterprise banking by driving sales of innovative SaaS solutions. Leverage your expertise to identify key clients, build relationships, and close complex deals, all while collaborating with...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.