Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Sales Development Representative
$76K - $115K *
Accelerate progress at a dynamic SaaS company by driving revenue through outbound prospecting and lead generation. Collaborate with Account Executives to engage decision-makers and contribute to the s...
2 weeks ago
Senior Partner Sales Executive - Strategic Commercial
$222K - $360K *
Drive growth by developing and executing strategic partnerships with large enterprises. Leverage your expertise to enhance relationships, optimize offerings, and lead cross-functional collaboration fo...
2 weeks ago
$120K - $145K *
Empower global manufacturing by leading automation strategies and teams, driving productivity and quality improvements across cable assembly operations. Ensure consistent execution and replication of...
2 weeks ago
Territory Sales Manager - Specialty (Portland, OR)
$113K - $142K *
Shape the future of healthcare by driving sales growth and building strong relationships. Leverage your clinical expertise and market insights to exceed objectives and enhance market share in a dynami...
2 weeks ago
$120K - $150K *
Reimagine brand identity and creative direction, leading a dynamic team to elevate packaging, campaigns, and content. Drive innovative storytelling and community experiences while collaborating across...
2 weeks ago
Software Engineer II, Frontend (Marketing and Privacy)
$146K - $206K *
Join a dynamic team to enhance high-traffic web experiences, driving consumer acquisition through innovative marketing technology and experimentation. Collaborate across functions to deliver reliable...
2 weeks ago
Senior Marketing Technology Strategist
$110K - $130K *
Drive the strategy and execution of marketing technology initiatives, optimizing automation and revenue operations. Collaborate with cross-functional teams to enhance engagement and performance metric...
2 weeks ago
$104K - $149K *
Drive quality and audit excellence by managing the Quality Standards Framework and Internal Audits, ensuring alignment with regulatory requirements and continuous improvement within the Integrated Man...
Reposted 2 weeks ago
Clinical Application Specialist
$80K - $90K *
Shape the future of Cell and Gene Therapy by providing expert application support, driving customer integration, and enhancing product utilization through collaboration and technical guidance across t...
2 weeks ago
$125K - $220K *
Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...
2 weeks ago
Sr. Engineer, AI Cyber Security
$140K - $187K *
Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...
2 weeks ago
Senior Mainframe Systems Programmer - IMS Phyical
$85K - $148K *
Join a dynamic team providing expert software support for mainframe IMS systems. Engage in customer service, problem resolution, and migration services while adhering to best practices and ensuring ti...
2 weeks ago
Senior Mainframe Systems Programmer - MQ
$60K - $152K *
Engage with clients to deliver exceptional software support for MQ on mainframe systems. Collaborate across teams to ensure timely installations, upgrades, and migrations while adhering to best practi...
2 weeks ago
Senior Project Manager (City and County)
$130K - $154K *
Lead complex projects to enhance organizational efficiency, manage timelines, and coordinate cross-functional teams. Drive strategic goals while ensuring compliance and fostering strong stakeholder re...
2 weeks ago
Content Marketing Manager - Remote
$80K - $95K *
Innovate your career by leading the strategy and creation of impactful B2B content across various formats. Collaborate with teams to enhance engagement and drive demand through high-quality, optimized...
2 weeks ago
$94K - $107K *
Support and enhance data governance operations by collaborating with teams to implement standards, manage data cataloging, and drive tool adoption, ensuring compliance and effective governance workflo...
2 weeks ago
Director- Allied Health Programs
$80K - $90K *
Elevate healthcare education by leading the development of innovative allied health programs. Drive growth and improvement through strategic partnerships, curriculum design, and compliance, ensuring l...
2 weeks ago
Principal Design Program Manager, International Packaging
$120K - $145K *
Lead the charge in shaping global healthcare packaging design. As a Principal Design Program Manager, you'll establish frameworks and standards, drive strategic decisions, and ensure seamless collabor...
2 weeks ago
Strategic Alliances Manager - North America Partner Program
$110K - $130K *
Shape the future of partner engagement by building a North American partner program from the ground up. Design strategies, recruit boutique agencies, and drive co-sell motions to generate impactful pa...
2 weeks ago
$140K - $270K *
Unlock potential by designing and deploying scalable AI systems that transform healthcare workflows. Collaborate with cross-functional teams to solve complex business challenges and drive measurable o...
2 weeks ago
Consumption Pricing Monetization Lead
$105K - $155K *
Unlock potential by leading the strategy for consumption-based pricing. Drive the execution of innovative pricing models and processes, collaborating with cross-functional teams to enhance customer ex...
2 weeks ago
Senior Operational Risk Manager
$179K - $249K *
Lead the charge in shaping and executing the Operational Risk program, collaborating with key teams to enhance risk management practices and reporting as the organization transitions to banking operat...
2 weeks ago
Field Sales Manager, Los Angeles
$90K - $120K *
Elevate brand presence through in-store execution, relationship-building, and training. Drive sales support and visual merchandising while collaborating with key accounts to enhance customer experienc...
2 weeks ago
Senior Manager, Database Platform
$242K - $275K *
Lead and elevate the Database Platform team, driving data architecture, reliability, and team culture for scalable data solutions. Collaborate cross-functionally to ensure data integrity and operation...
2 weeks ago
Manager, Support Engineering (AMER)
$115K - $194K *
Lead a dynamic Support Engineering team, enhancing customer experiences through AI-driven solutions, mentorship, and scalable processes while fostering a culture of growth and accountability...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.