Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$125K - $150K *

Help us transform finance functions into strategic drivers for growth. You will provide expert accounting and financial support to clients, enhancing their finance operations during buy-side and sell...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Transform finance functions into strategic drivers for growth by delivering expert accounting and financial support to clients. Lead engagements, enhance processes, and drive performance improvements...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$165K *

Engage in cutting-edge AI projects by developing and deploying NLP models. Collaborate with cross-functional teams to optimize performance and scalability, utilizing frameworks like PyTorch or TensorF...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$244K - $279K *

Drive your career with a leadership role in AI engineering, overseeing innovative projects that enhance customer interactions and empower teams. Collaborate across functions to deliver scalable AI sol...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $145K *

Advance your career by leading strategic partnerships and managing fiscal sponsorship projects. Collaborate with clients and stakeholders to ensure successful outcomes while providing expert guidance...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$300K - $500K+*

Join a dynamic team to design and implement cutting-edge Machine Learning solutions that enhance content discovery and promotion strategies, driving member engagement and optimizing generated assets f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$315K - $500K+*

Innovate dynamic gameplay systems by leveraging Generative AI to enhance player experiences. Collaborate closely with designers to prototype and integrate AI features, ensuring seamless performance an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$90K - $120K *

Elevate your career by leading clients through the CMMC 2.0 compliance journey. As a key advisor, you'll translate complex regulations into actionable strategies, ensuring audit readiness and security...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$109K - $150K *

Shape the future of security solutions by guiding complex Managed Services integrations. Collaborate with teams to align customer strategies, mitigate risks, and ensure compliance, while leading techn...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$84K - $112K *

Lead the charge in developing high-performing marketing teams and driving strategic growth initiatives. Collaborate with operations and business development to enhance proposal success and elevate bra...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

Drive financial excellence by integrating and analyzing revenue and expense forecasts, ensuring alignment across functions. Collaborate with FP&A teams to deliver actionable insights and support strat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$172K - $240K *

Join a team that's redefining AI security! As a Principal AI Security Engineer, you'll lead assessments, design controls, and partner with teams to ensure safe AI adoption across the enterprise, drivi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$143K - $193K *

Empower global clinical operations by leading process management initiatives, ensuring compliance and efficiency. Collaborate with cross-functional teams to enhance quality and drive innovations in cl...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $203K *

Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$136K - $181K *

Join a team that's dedicated to managing Veeva platforms, ensuring compliance and operational excellence. This role involves collaborating with global stakeholders to enhance system performance and su...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$172K - $232K *

Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$122K - $204K *

Optimize global trade compliance by leading initiatives that ensure adherence to import, export, and customs regulations while balancing operational efficiency and commercial objectives across diverse...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$99K - $117K *

Shape the future of hotel performance by driving commercial success for a portfolio of franchised properties. Collaborate with stakeholders to enhance revenue, market share, and owner profitability th...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Hospitality & Recreation

$99K - $117K *

Drive commercial performance for a portfolio of franchised hotels by leveraging data to identify growth opportunities. Collaborate with stakeholders to enhance revenue strategies, improve profitabilit...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Hospitality & Recreation

$163K - $192K *

Unlock potential by leading a dynamic team to optimize revenue strategies across Upscale Brands. Drive performance, enhance service delivery, and ensure franchisee success through effective change man...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$229K - $267K *

Optimize consumer acquisition strategies to drive growth and innovation across multiple channels. Lead a high-performing team, manage budgets, and define future goals while ensuring effective executio...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$229K - $267K *

Innovate the consumer digital experience by leading a cross-functional team to enhance our website, mobile app, and web portal. Define a multi-year vision, prioritize initiatives, and drive engagement...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in enhancing rehabilitation operations across multiple facilities. Drive clinical excellence, manage staff, and ensure compliance while fostering a supportive environment for both pati...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Unlock innovative AI/ML solutions by collaborating with cross-functional teams, conducting research, and deploying production-grade microservices. Drive impactful projects with ownership and contribut...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead quality and patient experience initiatives, shaping strategies to enhance safety and care across the organization. Collaborate with leadership to drive improvements and foster a culture of safety...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.