Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$75K - $90K *

Deliver exceptional tax consulting services by guiding customers through the implementation of tax solutions, ensuring compliance with federal, state, and local regulations while fostering strong rela...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $202K *

Innovate and build AI-native products that automate complex workflows. Collaborate with cross-functional teams to design, develop, and deploy full-stack applications, ensuring reliability and performa...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Empower our privacy program by automating processes, managing data subject requests, and ensuring compliance with GDPR and CCPA. You'll leverage technical skills to build scalable tools and systems, d...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$206K - $261K *

Accelerate the commercialization of AI-driven solutions by leading strategy and planning efforts. Collaborate cross-functionally to define go-to-market frameworks, enhance retailer experiences, and dr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$85K *

Innovate the future of asset protection by investigating theft and fraud, ensuring compliance, and safeguarding company resources through detailed analysis and collaboration with cross-functional team...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $120K *

Elevate brand presence through in-store execution, training, and relationship-building. Drive sales support and visual merchandising while collaborating with key accounts to enhance customer experienc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$241K - $272K *

Unlock potential by leading integrated marketing strategies that enhance customer and partner engagement, drive revenue growth, and strengthen relationships across sales and channel operations in a dy...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$76K - $115K *

Accelerate progress at a dynamic SaaS company by driving revenue through outbound prospecting and lead generation. Collaborate with Account Executives to engage decision-makers and contribute to the s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $145K *

Empower global manufacturing by leading automation strategies and teams, driving productivity and quality improvements across cable assembly operations. Ensure consistent execution and replication of...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$113K - $142K *

Shape the future of healthcare by driving sales growth and building strong relationships. Leverage your clinical expertise and market insights to exceed objectives and enhance market share in a dynami...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Reimagine brand identity and creative direction, leading a dynamic team to elevate packaging, campaigns, and content. Drive innovative storytelling and community experiences while collaborating across...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$146K - $206K *

Join a dynamic team to enhance high-traffic web experiences, driving consumer acquisition through innovative marketing technology and experimentation. Collaborate across functions to deliver reliable...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Drive the strategy and execution of marketing technology initiatives, optimizing automation and revenue operations. Collaborate with cross-functional teams to enhance engagement and performance metric...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$104K - $149K *

Drive quality and audit excellence by managing the Quality Standards Framework and Internal Audits, ensuring alignment with regulatory requirements and continuous improvement within the Integrated Man...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $90K *

Shape the future of Cell and Gene Therapy by providing expert application support, driving customer integration, and enhancing product utilization through collaboration and technical guidance across t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $220K *

Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $187K *

Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $148K *

Join a dynamic team providing expert software support for mainframe IMS systems. Engage in customer service, problem resolution, and migration services while adhering to best practices and ensuring ti...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$60K - $152K *

Engage with clients to deliver exceptional software support for MQ on mainframe systems. Collaborate across teams to ensure timely installations, upgrades, and migrations while adhering to best practi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $154K *

Lead complex projects to enhance organizational efficiency, manage timelines, and coordinate cross-functional teams. Drive strategic goals while ensuring compliance and fostering strong stakeholder re...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Innovate your career by leading the strategy and creation of impactful B2B content across various formats. Collaborate with teams to enhance engagement and drive demand through high-quality, optimized...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$94K - $107K *

Support and enhance data governance operations by collaborating with teams to implement standards, manage data cataloging, and drive tool adoption, ensuring compliance and effective governance workflo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $90K *

Elevate healthcare education by leading the development of innovative allied health programs. Drive growth and improvement through strategic partnerships, curriculum design, and compliance, ensuring l...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Lead the charge in shaping global healthcare packaging design. As a Principal Design Program Manager, you'll establish frameworks and standards, drive strategic decisions, and ensure seamless collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Shape the future of partner engagement by building a North American partner program from the ground up. Design strategies, recruit boutique agencies, and drive co-sell motions to generate impactful pa...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.