Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$95K - $125K *

Drive the deployment of healthcare technology across multiple VA facilities, coordinating projects and ensuring readiness. Collaborate with diverse teams to manage timelines, resolve issues, and deliv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Drive strategic sourcing and vendor negotiations to optimize technology spend, leveraging AI for pricing benchmarks and contract reviews. Collaborate cross-functionally to enhance procurement processe...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$186K - $233K *

Empower the future of real-world analytics by leading programming activities for observational studies, ensuring high-quality deliverables through collaboration with cross-functional teams and innovat...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$97K - $118K *

Lead the charge in developing and executing strategic sales initiatives for large accounts, fostering key relationships to drive long-term revenue growth and market penetration while collaborating acr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$84K - $148K *

Empower database excellence by managing Software AG ADABAS environments, ensuring optimal performance, and providing 24x7 support. Collaborate with vendors and clients to resolve issues, maintain docu...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$107K - $145K *

Drive growth by identifying and securing new business opportunities in risk management and medical education. Collaborate with teams to develop proposals, manage sales pipelines, and ensure alignment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$238K - $357K *

Transform growth strategies by leading AI initiatives, targeting key customers, and driving adoption through innovative partnerships and market insights. Collaborate across teams to enhance product of...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $155K *

Elevate your career by joining a dynamic Medical Affairs team, where you'll lead Medical Information initiatives, ensure compliance, and drive strategic insights to support our innovative pipeline in...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by leading the design and optimization of enterprise workflows. Collaborate with cross-functional teams to enhance operational efficiency and drive data-driven decisions within a dyna...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $90K *

Elevate performance video creation by transforming strong ideas into compelling ads that engage serious entrepreneurs, driving qualified demand and enrollment calls through creative storytelling and s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$220K - $275K *

Elevate your career by leading global CMC regulatory strategies for biologics. Collaborate with cross-functional teams, ensure compliance, and drive successful product development while mentoring a hi...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Shape the future of battery storage procurement by leading strategic sourcing, negotiating contracts, and driving supplier performance to ensure cost competitiveness and supply security in a dynamic g...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$89K - $155K *

Champion customer relationships and drive revenue growth by managing a rotating portfolio of Fortune 500 accounts. Leverage advertising expertise and AI tools to enhance performance and deliver measur...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $135K *

Join a team that's driving innovative marketing strategies to enhance brand visibility and support growth objectives. Lead a dynamic marketing team, manage campaigns, and collaborate with executives t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Lead the charge in driving revenue growth and team performance by developing innovative sales strategies, coaching talent, and fostering client relationships to enhance business outcomes in technology...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $180K *

Empower the powered land development function by sourcing, evaluating, and advancing sites for solar and storage projects. Lead negotiations, engage stakeholders, and build financial models to transfo...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$186K - $233K *

Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$173K - $200K *

Elevate rebate product strategy by leading development, driving growth, and enhancing operational performance. Collaborate across teams to ensure compliance and deliver measurable outcomes that align...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$102K - $148K *

Lead the charge in managing Mainframe Systems Programming teams, ensuring project alignment and team development. Drive performance through mentoring, risk management, and effective communication whil...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$65K - $123K *

Optimize storage infrastructure by managing DASD and tape systems, ensuring efficient backups, migrations, and disaster recovery. Collaborate with clients and vendors while mentoring team members to e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$113K - $276K *

Explore the transition and stabilization of SAP BW applications, ensuring effective data modeling and reporting across finance and supply chain. Collaborate globally to maintain performance and compli...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join us to elevate brand experiences through innovative design. Collaborate with cross-functional teams, drive projects from concept to delivery, and leverage AI tools to enhance creativity in a dynam...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Champion AI deployment by designing and implementing innovative solutions across multiple platforms. Collaborate with teams to enhance customer experiences while ensuring data governance and security...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Engage in designing and implementing robust cybersecurity solutions while managing security technologies and cloud services. Collaborate across teams to ensure operational performance and support clie...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $235K *

Champion healthcare coding excellence by optimizing operations, implementing automation, and enhancing training. Collaborate with leaders to drive measurable improvements in productivity and accuracy...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.