Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$80K - $95K *

Execute comprehensive project management for hospital and clinic construction, overseeing all phases from design to occupancy. Collaborate with stakeholders to ensure compliance, budget adherence, and...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $280K *

Shape the future of our enterprise sales segment by driving growth and account success. Take ownership of new logo acquisitions, deepen existing client relationships, and establish best practices for...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$213K - $243K *

Champion the development of a robust commercial data strategy, ensuring high-quality, AI-ready data solutions that drive impactful decision-making and enhance commercial performance across the organiz...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$155K - $175K *

Champion the field as a Medical Science Liaison, driving prelaunch strategies and fostering relationships with key stakeholders. Leverage clinical insights to educate and influence healthcare professi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $140K *

Transform your career by driving growth and adoption of innovative surgical glaucoma technology. Engage with healthcare professionals, deliver expert support, and build lasting relationships to enhanc...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$145K - $165K *

Champion revenue growth by building partnerships with city officials and transport operators. Navigate complex sales cycles, execute market plans, and provide strategic insights for sustainable public...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$100K - $130K *

Champion customer relationships and drive sales strategies to enhance loyalty and achieve targets. Collaborate with teams to execute action plans, manage distributor salesforces, and ensure excellence...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$80K - $95K *

Create compelling, compliant proposals for federal contracts, collaborating with cross-functional teams to translate technical concepts into persuasive narratives that meet government requirements and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $115K *

Lead the charge in managing a dynamic team to adjudicate complex workers' compensation claims, ensuring timely resolutions and innovative solutions for diverse clients while fostering a culture of gro...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$165K - $190K *

Unlock potential by leading licensing and business contracts, providing strategic legal support across teams, and managing a talented unit to ensure effective contract governance and compliance in a d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$111K - $159K *

Transform cloud strategies by building secure, scalable AWS platforms that elevate operational excellence and enhance developer productivity through automation and engineering best practices...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Unlock potential by driving sales strategies in the Defined Contribution space, cultivating relationships with key intermediaries while managing a robust sales pipeline to enhance market presence and...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Champion the success of a dynamic lab team by overseeing daily operations, ensuring compliance, and driving performance. Collaborate across departments to enhance processes and maintain high-quality s...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Unlock potential by leading quality initiatives across multiple manufacturing sites. Drive improvements, standardize best practices, and collaborate with cross-functional teams to enhance customer sat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Join a team that's shaping the future of commercial legal operations by supporting diverse contracting efforts and building scalable legal frameworks that drive business growth and innovation...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $175K *

Empower Apollo's frontier partnerships by deepening collaborations with AI-native platforms and foundation model companies. Analyze the evolving landscape and drive monetization strategies while build...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $130K *

Unlock your potential as a Cyber Analyst (Tier 2) / Incident Commander, managing escalated cybersecurity incidents in a 24/7 operations center. Drive incident response, stakeholder communication, and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $190K *

Shape the enterprise architecture landscape by aligning technology across core platforms, establishing standards, and driving strategic initiatives. Collaborate with cross-functional teams to enhance...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Empower organizations by driving adoption of Power Platform solutions, modernizing systems, and automating processes. You'll develop new and existing relationships, collaborating with teams and partne...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$147K - $220K *

Drive the success of clinical study projects by managing timelines, budgets, and quality standards. Collaborate with teams and clients to ensure project objectives are met while fostering a culture of...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$116K - $171K *

Elevate customer success by partnering with developers to implement solutions, troubleshoot technical issues, and enhance product features. Your insights will drive improvements across teams, ensuring...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$94K - $266K *

Lead transformative customer engagements by managing relationships, guiding project teams, and driving innovative solutions. Collaborate with stakeholders to ensure successful delivery and account gro...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Unlock potential by enhancing application security across web apps and APIs. Collaborate with engineering teams to assess risks, conduct reviews, and drive secure software practices throughout the dev...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$106K - $160K *

Pioneer impactful tax strategies and team development while managing client relationships and compliance for insurance-related taxation. Drive growth through mentoring and technical expertise in the e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $200K *

Lead the strategy and delivery of complex, high-impact products, collaborating with cross-functional teams to align investments with business objectives. Drive customer-centric innovation while mentor...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.