Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$150K - $180K *
Innovate cutting-edge AI financial solutions by architecting and deploying advanced chat interfaces and reporting systems. Collaborate with elite engineers to enhance investment workflows for global c...
2 weeks ago
$140K - $175K *
Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...
2 weeks ago
$225K - $275K *
Lead the Consultant Relations strategy by fostering deep relationships with major consulting firms, ensuring proactive engagement in live deals, and driving business growth through effective account m...
2 weeks ago
$213K - $321K *
Lead and develop a high-performing sales team, driving regional growth through effective strategy, coaching, and relationship-building. Own forecasting and operational cadence while fostering a cultur...
2 weeks ago
Product Quality Analyst II (Remote)
$65K - $99K *
Join a team that's dedicated to enhancing software quality through rigorous testing of web applications and APIs. Collaborate with engineers and analysts to document defects and improve client satisfa...
2 weeks ago
$125K - $150K *
Join a team that's redefining global events management by leading a dynamic program management function. Oversee flagship conferences and regional events, ensuring strategic alignment, operational exc...
2 weeks ago
Director, Employer Sales - National Accounts
$349K - $396K *
Lead the charge in driving national growth strategies for enterprise employers, managing a top-performing sales team focused on Fortune 500 engagements, overseeing the acquisition lifecycle, and ensur...
Reposted 2 weeks ago
Senior Gameplay Designer (Combat & AI)
$118K - $177K *
Shape the future of multiplayer gaming by creating engaging AI systems that enhance player experiences. Collaborate with a dynamic design team to deliver innovative gameplay that prioritizes team play...
Reposted 2 weeks ago
$85K - $122K *
Champion cross-border sales by targeting and developing sustainable business with international customers. Collaborate with teams to drive revenue growth and enhance customer relationships in a fast-p...
2 weeks ago
$140K - $270K *
Unlock your potential as a Research Scientist, driving AI innovations in healthcare. Collaborate with cross-functional teams to develop and implement cutting-edge machine learning models that enhance...
Reposted 2 weeks ago
$186K - $203K *
Design impactful monetization experiences that enhance user engagement and drive revenue. Collaborate with cross-functional teams to create seamless, user-centered journeys while leveraging AI tools t...
2 weeks ago
Global Expansion Project Manager - FedRAMP
$100K - $130K *
Champion global expansion initiatives by managing the FedRAMP program. Collaborate with cross-functional teams to ensure project timelines and deliverables are met while navigating a fast-paced enviro...
2 weeks ago
$150K - $185K *
Lead the development of innovative AI products that empower job seekers with evidence-based coaching and actionable insights, while collaborating closely with cross-functional teams to shape impactful...
2 weeks ago
$180K - $220K *
Transform a global brand and communications strategy with innovative AI insights. Lead integrated narratives that build trust, drive market growth, and enhance corporate reputation across diverse audi...
Reposted 2 weeks ago
Principal Merchant Success Manager
$115K - $192K *
Drive success by managing strategic merchant partnerships, blending account management and operations to enhance performance and growth. Collaborate cross-functionally to deliver scalable solutions an...
2 weeks ago
Staff Machine Learning and Bioinformatics Scientist (Multi-Cancer Early Detection)
$163K - $204K *
Unlock potential by leading innovative machine learning methods for cancer detection, collaborating with experts, and mentoring junior scientists to advance research in multi-cancer early detection us...
2 weeks ago
Client Engagement Director- Preferred candidates Chicago land area / Midwest
$175K - $215K *
Drive strategic growth and client satisfaction by managing senior-level relationships, leveraging cross-functional resources, and delivering measurable business value in a dynamic market environment...
2 weeks ago
$150K - $180K *
Champion growth by leading regional sales across diverse markets while developing a top-performing team of Account Executives. Drive sales strategies, forge strong partnerships, and elevate enterprise...
Reposted 2 weeks ago
Staff Software Engineer, Tech Lead - NetBox Delivery
$135K - $160K *
Unlock the potential of NetBox Delivery by leading software design, enhancing production reliability, and mentoring engineers. Shape the technical direction and ensure seamless deployment on Cloud and...
2 weeks ago
Senior Clinical Project Manager
$120K - $145K *
Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...
2 weeks ago
$204K - $330K *
Transform security operations by leading a dynamic Product Security team. Drive risk-based strategies, empower engineering teams, and enhance security posture through automation and collaboration. Sha...
2 weeks ago
$110K - $130K *
Join a dynamic team as a SOC Engineer, where you'll onboard customers into managed security services, configure Microsoft security tools, and ensure reliable telemetry across diverse environments, all...
2 weeks ago
$109K - $136K *
Take ownership of Treasury operations by managing cash movements, automating reporting processes, and enhancing efficiency through innovative tools. Collaborate cross-functionally to ensure accurate f...
2 weeks ago
Programming & Editorial Manager
$110K - $130K *
Transform your career by leading content strategy and production for dynamic digital channels. Drive audience engagement and performance through compelling storytelling, collaboration, and innovative...
2 weeks ago
$80K - $90K *
Join a team that's dedicated to enhancing recruiting standards and practices. Collaborate with HR and leadership to implement effective strategies, drive candidate engagement, and ensure a robust tale...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.