Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$97K - $126K *
Transform marketing strategies by connecting buyer needs with sales execution. Lead integrated campaigns, enhance customer engagement, and drive growth through innovative go-to-market planning and col...
2 weeks ago
Institutional Business Manager - Connecticut
$110K - $130K *
Lead the charge in developing strategic business plans to establish key relationships across diverse medical subspecialties, driving sales growth and maximizing ROI through effective territory managem...
2 weeks ago
Hospital & Specialty Sales Representative - West Chicago
$110K - $130K *
Join a team that's dedicated to developing and executing a strategic business plan to engage healthcare professionals across diverse medical subspecialties, while driving sales growth and building key...
Reposted 2 weeks ago
Principal, Data Governance Platforms
$149K - $224K *
Shape the future of data governance by leading the design and implementation of enterprise platforms that ensure data integrity, quality, and compliance across the organization, while collaborating wi...
2 weeks ago
AI First iOS Software Engineer (Remote)
$85K - $125K *
Accelerate progress at the forefront of mobile development by leveraging AI tools to enhance iOS applications. Collaborate with cross-functional teams to deliver high-quality, customer-centric marketp...
2 weeks ago
AI First Sr. Android Developer
$125K *
Transform the future of mobile development by leveraging AI to enhance marketplace experiences. Collaborate with cross-functional teams to design, build, and ship high-quality Android applications tha...
2 weeks ago
$110K - $130K *
Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...
2 weeks ago
$116K - $167K *
Elevate your career by leading planned giving strategies and donor engagement. Collaborate across teams to enhance legacy giving, cultivate relationships, and drive philanthropic support while managin...
2 weeks ago
$100K - $120K *
Join a team that's transforming women's health by driving sales in OB/GYN and maternal-fetal medicine. You'll manage the full sales cycle, leveraging existing relationships to expand our reach and ens...
2 weeks ago
Institutional Business Manager - South Atlanta
$110K - $130K *
Join a team that's dedicated to building strategic relationships across diverse medical specialties, driving sales, and exceeding performance goals in a dynamic healthcare environment focused on innov...
Reposted 2 weeks ago
Institutional Business Manager - Central Valley, CA
$110K - $130K *
Innovate strategies to build relationships with healthcare professionals across diverse medical fields. Drive sales growth by leveraging data insights and managing key accounts while ensuring effectiv...
2 weeks ago
$110K - $130K *
Join our team to validate and enhance data migration processes through comprehensive testing, ensuring quality and performance in a dynamic Agile environment. Your expertise will drive successful syst...
2 weeks ago
Sr Director Analyst- Analytics & AI
$172K - $202K *
Lead the charge in delivering impactful research and insights in analytics and AI. Collaborate with clients to identify needs, drive strategies, and produce high-quality content that shapes market tre...
2 weeks ago
Sr. Software Engineer (C# .NET)
$112K - $155K *
Accelerate progress at a leading tech firm by developing scalable, cloud-native APIs. Collaborate with cross-functional teams to enhance core offerings and lead discussions on software architecture, e...
2 weeks ago
$100K - $182K *
Transform client operations by implementing Sage Intacct solutions, ensuring high satisfaction through effective project management and technical support. Collaborate with teams to deliver tailored so...
2 weeks ago
$125K - $150K *
Elevate your career by driving data engineering excellence in Palantir Foundry, transforming legacy systems into robust pipelines and applications while collaborating with cross-functional teams to de...
2 weeks ago
$120K - $150K *
Transform financial operations by leading a global accounting team, managing month-end closes, billing, cash flow, and audits. Drive process improvements and ensure compliance while fostering a collab...
2 weeks ago
$90K - $110K *
Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...
2 weeks ago
$145K - $185K *
Drive transformative supply chain strategies to enhance performance and synergy across sourcing, logistics, and plant management while maximizing cost savings and supplier relationships for organizati...
Reposted 2 weeks ago
Medicaid Data & Analytics Specialist
$80K - $95K *
Unlock your potential by analyzing Medicaid data to enhance program performance, quality, and access. Collaborate with diverse teams to develop insights that drive impactful decisions in healthcare an...
2 weeks ago
$85K - $125K *
Unlock your potential as an AI-first Software Engineer, driving innovation in mobile marketplace experiences. Collaborate with cross-functional teams to enhance product quality and efficiency while le...
2 weeks ago
$100K - $120K *
Help us bridge legacy systems with modern data integration by analyzing, documenting, and translating existing application logic for migration. Collaborate with engineers to ensure seamless transition...
2 weeks ago
Technical Lead (Data Science and AI/ML)
$125K - $150K *
Empower teams by providing technical leadership in data science and AI/ML, driving enterprise data modernization initiatives. Collaborate with stakeholders to design and deliver impactful decision-mak...
2 weeks ago
$150K - $180K *
Unlock potential by leading technical sales engagements in quantum computing, guiding customers through complex challenges, and delivering tailored solutions across diverse industries while collaborat...
2 weeks ago
Legal Counsel, Federal & Procurement
$177K - $243K *
Manage legal support for federal contracts, guiding teams on compliance, risk, and negotiations. Drive contract administration and develop solutions for complex agreements in the healthcare sector, en...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.