Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$120K - $145K *

Drive innovation in AI by building and evaluating machine learning models. Collaborate with experts to design experiments, analyze data, and communicate findings effectively to enhance model performan...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by driving the design and deployment of AVEVA MES projects. Collaborate with cross-functional teams to ensure quality solutions, mentor junior engineers, and enhance user adoption...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$62K - $139K *

Champion data integrity by designing and executing comprehensive test plans for ETL processes and large-scale data platforms, ensuring quality and accuracy across systems while collaborating in an Agi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$112K - $141K *

Innovate customer success in quantum computing by driving adoption and technical enablement. Collaborate with cross-functional teams to optimize performance, design workflows, and create educational c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$67K - $199K *

Unlock your potential as you design and develop impactful Power BI solutions, enhancing analytics capabilities and driving strategic decision-making in a dynamic sales environment. Collaborate with cr...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Engineer cutting-edge blockchain infrastructure for financial markets. Drive architecture, design proofs of concept, and ensure interoperability while collaborating with teams to meet institutional re...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $120K *

Lead the charge in enhancing safety standards across multiple construction projects. Collaborate with field teams to ensure compliance and improve practices, making safety a priority and fostering a c...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$82K - $108K *

Grow your career with a dynamic role focused on building relationships and driving sales growth in the wholesale sector. Collaborate with internal teams to deliver exceptional customer service and ach...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Champion the development of scalable, cloud-native applications, enhancing data pipelines and integrations. Collaborate with teams to transform raw data into actionable insights, driving improvements...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $120K *

Advance patient care at our Virtual Cancer Clinic by providing essential support, education, and coordination for cancer screening and prevention, ensuring timely follow-up and compassionate care for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's driving strategic growth through partnerships with GSIs, MSPs, and VARs. This role combines relationship building, market strategy, and sales leadership to generate revenue and opti...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$83K - $152K *

Shape the future of Category Partnerships by crafting compelling narratives and sales materials that drive engagement and revenue. Collaborate with teams to translate insights into strategic stories t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$110K - $130K *

Develop and enhance JD Edwards applications to drive business efficiency across departments. Collaborate with analysts to create solutions that meet specifications and improve processes in a manufactu...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$145K - $185K *

Champion strategic pursuits in the Space ecosystem, driving acquisition and partnerships. Lead full-lifecycle capture efforts to align technical solutions with government needs, influencing pipeline g...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$145K - $185K *

Drive business growth by leading full-lifecycle opportunities within the Space Force, building relationships, shaping solutions, and ensuring contract execution while managing a diverse portfolio and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Engage in dynamic business development within the defense sector, identifying and nurturing new opportunities. Leverage strong communication skills and industry knowledge to build lasting relationship...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform business operations by leading systems and technology initiatives that enhance efficiency, drive AI enablement, and streamline processes across the organization, ensuring a robust foundation...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$64K - $96K *

Transform health information management by auditing coding practices, providing expert consultation, and delivering educational workshops to enhance compliance and efficiency across various healthcare...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $240K *

Drive the product vision and strategy, collaborating across teams to create innovative solutions that enhance customer experiences and business growth in a dynamic, remote-first environment...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$165K - $220K *

Optimize global payroll operations by leading strategy, governance, and modernization efforts. Drive compliance and efficiency across 25+ countries while fostering cross-functional partnerships and en...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$105K - $135K *

Join a dynamic team as you drive growth and manage strategic customer relationships in the Bus, Truck, Rail, and Specialty Vehicles market, leveraging innovative adhesive solutions to achieve business...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$140K - $155K *

Pioneer your career in cell therapy innovation by leading method transfers and validations. Collaborate with cross-functional teams to ensure compliance and drive quality in late-stage clinical develo...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$177K - $221K *

Empower compliance excellence by leading the NSCLC field compliance program. Collaborate with cross-functional teams to identify risks, develop scalable solutions, and ensure adherence to regulations...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $180K *

Drive operational excellence by managing the leadership team's cadence, metrics, and contract operations. This hands-on role blends business judgment with execution, ensuring alignment and efficiency...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Champion compliance excellence by leading innovative technology integration and regulatory strategies across Medicare Advantage and Part D channels, ensuring seamless operations and enhanced agent eff...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.