Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$130K - $160K *

Lead the development of innovative compliance solutions for multi-state workforces, ensuring efficient policy management and training. Collaborate with cross-functional teams to enhance user experienc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $244K *

Join us as a Lead Product Designer to shape a groundbreaking Rentals experience, collaborating with a senior team to define and deliver innovative solutions for renters and property managers in a fast...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Manage and grow client relationships while driving revenue growth and mentoring staff. Engage proactively with clients, align with community initiatives, and ensure seamless transitions for new client...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $110K *

Engage with clients, driving success in digital campaign execution. Become an expert in programmatic advertising processes, enhancing customer satisfaction through effective communication and collabor...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Advance your career by providing expert monitoring for clinical trials, ensuring compliance with GCPs and SOPs. Collaborate with study teams, mentor peers, and enhance site performance through effecti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Empower financial decision-making by leading analysis, forecasting, and budgeting. Collaborate with cross-functional teams to deliver insights and enhance reporting efficiency using advanced tools and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$161K - $273K *

Transform client relationships and drive revenue growth by leveraging deep industry expertise and consultative selling skills. Collaborate with teams to deliver tailored payment solutions and lead com...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $175K *

Elevate your career by leading data, analytics, and AI initiatives that drive strategic decision-making and operational excellence. Shape the future of our data ecosystem while collaborating with seni...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$157K - $185K *

Drive growth by selling innovative AI security solutions to large public sector agencies. Leverage your expertise in complex sales cycles to uncover pain points and deliver tailored solutions, while m...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $160K *

Lead the charge in building AI agent discovery across cloud platforms and endpoints. Develop security assessments for AI agents that enhance the overall governance within our AI security framework, re...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$145K - $175K *

Lead the charge in managing enterprise client relationships, translating AI workforce development into measurable business impact. Drive strategic account plans, build trusted partnerships, and ensure...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$77K - $115K *

Join a team that's driving innovation in IT solutions by leveraging your expertise in systems analysis and functional design. Collaborate with cross-functional teams to enhance business processes and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Engage in advanced security operations as a Senior Security Analyst, leading incident response, enhancing detection capabilities, and driving process improvements to protect critical assets in a dynam...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$105K - $163K *

Engage with healthcare enterprises to drive sales strategies, develop key relationships, and close new business opportunities. Collaborate across functions to enhance market presence and exceed revenu...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$136K - $160K *

Elevate operations through AI-driven automation to enhance incident management, streamline ticket resolution, and optimize service health with self-healing observability, all while collaborating acros...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$73K - $103K *

Support a global workforce by delivering exceptional IT solutions. Manage user lifecycle processes, troubleshoot modern workplace technologies, and enhance IT operations through automation and documen...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $158K *

Shape the future of communications by partnering with clients to deliver innovative, technical solutions. Leverage your expertise to guide customers through complex challenges, ensuring their success...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$149K - $248K *

Champion client engagement and operational excellence by managing consulting teams, driving quality standards, and fostering relationships within Military Health Systems. Lead new business development...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$130K - $160K *

Unlock integrated marketing strategies to drive growth through data-driven campaigns, digital activation, and thought leadership, ensuring alignment with sales and operational goals for measurable bus...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$91K - $105K *

Elevate your career by driving strategic relationships with institutional consultants and advisors. Leverage market insights to enhance retirement and Stable Value investment solutions, ensuring succe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Accelerate progress at the intersection of autonomous systems and cloud-native technologies, driving integration and architecture solutions for defense and commercial sectors. Engage with stakeholders...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $200K *

Accelerate progress at regional Professional Services by leading teams, driving growth and quality in consulting engagements while fostering strategic partnerships and developing innovative service of...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $145K *

Help us shape the future of our brand by leading creative initiatives across campaigns, digital channels, and events. Collaborate with marketing teams to ensure a consistent visual identity and impact...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Pioneer innovative strategies as a Medical Science Liaison, engaging with key opinion leaders and driving platform adoption. Collaborate across teams to translate clinical needs into actionable insigh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $145K *

Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.