Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Regional Project Controls Manager
$91K - $121K *
Join a team that's pivotal in delivering large-scale PMO projects, managing budgets, schedules, and stakeholder communications. Drive cost control and enhance project performance through expert planni...
2 weeks ago
$90K - $110K *
Join our team to deliver innovative waste management solutions. Collaborate with clients to optimize operations through tailored technology integrations and enhance sustainability efforts while drivin...
Reposted 2 weeks ago
Principal Product Manager - AI Solutions
$189K - $246K *
Pioneer AI-driven product capabilities by translating complex challenges into actionable solutions that enhance user trust and drive measurable outcomes through collaboration across diverse teams...
Reposted 2 weeks ago
Senior Strategic Content Manager
$110K - $130K *
Transform your career by leading a high-performing team to create compelling thought leadership content. Drive strategic narratives that align with business priorities and market trends while fosterin...
2 weeks ago
Higher Education Enterprise Sales Manager
$137K - $179K *
Join a team that's dedicated to driving revenue growth by coaching and developing a high-performing sales organization. Lead a group of Account Executives to exceed targets and foster client relations...
2 weeks ago
Senior Director of Sales - Drive-Thru, Americas
$160K - $200K *
Champion growth by leading enterprise sales initiatives in the QSR sector. Drive strategic account development, build executive relationships, and convert opportunities into recurring revenue while es...
2 weeks ago
Psychiatric Complaints and Grievances Specialist (Remote)
$80K - $95K *
Lead the clinical review and resolution of psychiatric complaints, enhancing care quality across the network. Collaborate with clinical teams, investigate cases, and provide direct patient care, ensur...
2 weeks ago
Director of Strategic Accounts- Mid-Market MS/SC/AL
$122K - $187K *
Grow your career by driving strategic sales initiatives within key accounts. Collaborate with C-suite executives to deliver tailored technology solutions, ensuring exceptional customer experiences whi...
2 weeks ago
$155K - $210K *
Lead complex programs and strategic client engagements, driving technology transformation and sustainable business value. Act as a trusted adviser to C-level stakeholders, shaping program vision and e...
2 weeks ago
$110K - $130K *
Join us to lead the development and execution of clinical study designs, ensuring effective project management and collaboration across teams. Your expertise will drive the success of clinical trials...
2 weeks ago
$78K - $156K *
Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...
2 weeks ago
$110K - $130K *
Elevate client outcomes by managing complex AI and data programs. Serve as the primary contact for multi-geo teams, ensuring technical delivery aligns with business goals. Foster strong relationships...
Reposted 2 weeks ago
Senior Compliance Program Manager, GRC
$120K - $140K *
Drive compliance excellence as a Senior Compliance Program Manager, overseeing complex initiatives across enterprise and federal environments. Collaborate with cross-functional teams to ensure audit r...
2 weeks ago
Enterprise Regional Sales Manager - Federal Civilian (Remote, DMV)
$105K - $163K *
Empower growth in Federal sales by leveraging your expertise in cybersecurity. Drive strategic relationships with key decision-makers, develop account strategies, and exceed revenue targets in a dynam...
2 weeks ago
National Quality Performance Manager (Remote)
$90K - $110K *
Unlock potential by leading quality performance initiatives across departments, ensuring compliance and enhancing healthcare outcomes through data analysis and collaboration with stakeholders to drive...
2 weeks ago
Senior Director, Global Field Operations
$175K - $210K *
Lead global field operations, driving strategy and execution across sales, technical services, and partner functions. Collaborate with senior leadership to optimize pipeline management, forecasting, a...
2 weeks ago
Senior Director, Global Managed Cybersecurity Services
$160K - $200K *
Empower global cybersecurity service delivery by leading client-focused operations, driving growth, and ensuring excellence in managed services. Foster a high-performing team while enhancing client ou...
2 weeks ago
$165K - $190K *
Manage customer outcomes from onboarding through to renewal, driving success via strategic engagement and value realization. Be the go-to advisor ensuring alignment with business goals and optimizing...
Reposted 2 weeks ago
$110K - $125K *
Elevate your career by driving strategic sales initiatives in a dynamic environment. Leverage your expertise to build relationships, influence decision-makers, and expand market presence while managin...
2 weeks ago
Manager Robotic Sales Engineering
$120K - $145K *
Drive the success of a dynamic team of Robotic Sales Engineers, ensuring technical excellence and customer satisfaction while meeting sales quotas. Lead workshops, manage deal portfolios, and enhance...
2 weeks ago
Medical Oncologist, Clinical Care Lead
$275K - $350K *
Transform cancer care by delivering high-quality, evidence-based oncology services via telehealth. Collaborate with multidisciplinary teams to enhance patient outcomes and develop innovative care mode...
2 weeks ago
Health Plan Partnerships Manager
$100K - $115K *
Elevate your career by driving growth and operations in health plan partnerships. This role combines sales enablement and partner operations, directly impacting revenue through strategic collaboration...
2 weeks ago
GTM Strategy & Operations Manager- Special Projects
$147K - $211K *
Empower business leaders by driving strategic initiatives that enhance performance across Sales and Account Management. Utilize data-driven insights to translate complex challenges into actionable pla...
2 weeks ago
Head of Software Systems & Business Enablement
$180K - $220K *
Unlock potential by leading software systems management and optimization across a global portfolio. Collaborate with business and technology leaders to enhance operational efficiency, drive innovation...
2 weeks ago
IT Infrastructure & Support Analyst
$80K - $90K *
Analyze and enhance corporate technology infrastructure, ensuring optimal performance and security. Collaborate with cross-functional teams to troubleshoot complex issues and improve employee experien...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.