Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$80K - $95K *

Lead the strategic development and oversight of community behavioral health programs, ensuring high-quality, culturally responsive services. Collaborate with stakeholders to enhance community wellness...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $160K *

Partner with us to shape the quality strategy for a leading exam development platform. Leverage your expertise to guide multiple Agile teams, enhance automation practices, and ensure high standards ac...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Drive comprehensive legal support across diverse business functions, managing contracts, insurance, and litigation. Collaborate with cross-functional teams to ensure compliance and facilitate growth i...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$132K - $165K *

Drive innovation in oncology diagnostics by leading statistical programming efforts, ensuring data integrity and compliance for clinical trials, while managing a team and collaborating cross-functiona...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$126K - $171K *

Lead the charge in delivering innovative project management solutions for large law firms. Drive implementations, manage resources, and ensure client satisfaction while navigating complex challenges a...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$280K - $300K *

Pioneer innovative AI solutions in workforce management, leading product development from concept to deployment. Collaborate with engineers and executives to create impactful agentic products that enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive the evolution of the Marketing PMO, enhancing planning, governance, and execution across functions. Lead strategic programs, optimize workflows, and establish metrics to ensure predictable outco...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Elevate quality assurance by enhancing the Quality Management System for simulation products. Collaborate cross-functionally to ensure compliance, drive improvements, and maintain customer satisfactio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $220K *

Inspire global engineering teams to excel in delivering scalable, cloud-native solutions. Lead architectural strategy and foster a high-performance culture while driving AI-driven development practice...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Hospitality & Recreation

$124K - $170K *

Lead the charge in innovative software solutions for healthcare, collaborating with diverse teams to enhance patient care and meet customer needs through cutting-edge technology and creative problem-s...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$143K - $196K *

Lead the charge in driving procurement compliance and strategic initiatives, collaborating across functions to optimize processes and ensure adherence to regulations while supporting business goals an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $102K *

Lead the charge in delivering innovative structural designs for diverse projects, ensuring seamless collaboration across disciplines while mentoring junior engineers and overseeing construction admini...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$128K - $214K *

Accelerate digital underwriting innovation in life insurance by leading strategy, automation, and AI initiatives. Collaborate across teams to enhance efficiency, improve customer experience, and drive...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$125K - $150K *

Drive operational excellence by leading multi-team managers in executing compliant money movement flows. Collaborate cross-functionally to enhance customer experiences while ensuring risk mitigation a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Elevate our Salesforce environment by managing user access, automating workflows, and ensuring data integrity. Collaborate with cross-functional teams to enhance productivity and streamline processes...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$148K - $193K *

Join a dynamic team as a Program Manager, leading complex projects from inception to completion. Collaborate with diverse stakeholders, manage resources, and drive innovation while ensuring client sat...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$107K - $212K *

Transform client risk management by leading internal audits and controls. Collaborate with executives to enhance operational efficiency and compliance, while fostering a dynamic team environment that...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Advance software development by leading projects, mentoring engineers, and architecting solutions. Collaborate across teams to enhance performance and functionality while staying updated on technology...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Empower patient care by providing clinical support and training to surgical teams. Collaborate closely with healthcare professionals to ensure optimal outcomes and maintain equipment standards while m...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$193K - $309K *

Pioneer innovative developer experiences by setting technical direction and enhancing workflows. Collaborate across teams to design solutions that empower engineers, leveraging AI to redefine software...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$173K - $255K *

Champion the future of data infrastructure by leading a team to deliver scalable, reliable solutions for data access and processing, ensuring high availability and supporting critical business operati...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $160K *

Join a dynamic team to drive integrated marketing strategies that enhance brand visibility and support business growth through innovative campaigns, digital activation, and thought leadership across m...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $120K *

Lead the charge in driving operational excellence and strategic enablement across global Inside Sales teams, enhancing commercial effectiveness and delivering exceptional client value through innovati...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$143K - $180K *

Join a dynamic team as you lead financial oversight for managed and professional services. Drive revenue recognition, cost accounting, and compliance while collaborating with business leaders to enhan...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.