Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$72K - $97K *

Lead the charge in developing and executing a dynamic influencer marketing program, fostering relationships with creators and industry experts to enhance brand visibility and engagement across multipl...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Shape the future of business development by leading capture strategies and execution for high-value federal opportunities. Collaborate across teams to drive successful proposals and contract awards, e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$86K - $138K *

Lead the charge in defining product vision and strategy, aligning stakeholders, and overseeing execution. Collaborate across teams to prioritize clinical data assets, ensuring maximum business value a...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$92K - $139K *

Elevate your career by leading customer advocacy initiatives that drive engagement and impact. Collaborate cross-functionally to enhance customer relationships and leverage insights for program growth...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $110K *

Shape the future of trust and fiduciary services by driving business development, managing client relationships, and expanding market opportunities. Collaborate across teams to deliver tailored soluti...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $140K *

Pioneer GxP compliance in digital quality management, ensuring software and AI products meet regulatory standards. Collaborate with stakeholders to enhance quality processes and support audits, drivin...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $115K *

Grow and lead a high-performing BDR team, driving pipeline success through strategic coaching and data-driven insights. Collaborate cross-functionally to optimize sales processes and ensure seamless h...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$164K - $205K *

Lead the design and analysis of clinical validation studies, ensuring regulatory compliance and driving innovative research in molecular diagnostics. Collaborate with cross-functional teams to enhance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $111K *

Join a team that's dedicated to managing Oracle database systems, ensuring optimal performance and security across on-premises and cloud environments. Collaborate with development and infrastructure t...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$111K - $166K *

Transform Human Capital systems by leading daily operations, ensuring data accuracy, and enhancing employee processes. Collaborate with teams to implement improvements and provide hands-on support for...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$208K - $250K *

Shape the future of Grafana by leading frontend development squads, fostering collaboration and innovation to enhance user experiences. Drive AI integration and team growth while managing strategic pr...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team to lead and develop Channel AEs, driving growth in the Accountant sector. Collaborate cross-functionally to enhance partner success and exceed sales goals in a fast-paced environme...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$154K - $185K *

Join a team that's enhancing Grafana's data source plugins, ensuring reliability and seamless integration for users worldwide. Lead development efforts and collaborate to deliver world-class observabi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$112K - $143K *

Engage with key stakeholders to drive revenue growth and expand market share. This role requires strategic networking, relationship management, and a strong field presence to achieve sales targets and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Drive impactful product marketing strategies, leading positioning, pricing, and launches. Collaborate cross-functionally to transform insights into measurable results while building a robust product m...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $200K *

Unlock potential by designing and building innovative billing systems that simplify financial transactions and maximize reimbursements, while leveraging AI to enhance efficiency and user experience in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$62K - $103K *

Drive open-source research and analysis to support high-profile government clients. Conduct media monitoring, identify trends, and prepare concise reports to inform decision-making, all while working...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$68K - $113K *

Join a team that's dedicated to transforming disability claims through expert clinical assessments. Collaborate with healthcare providers and utilize your clinical expertise to improve patient outcome...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in enhancing security for a complex federal platform, safeguarding cloud infrastructure and sensitive data. Collaborate within an Agile team to design, implement, and automate robust s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $185K *

Champion growth by driving strategic sales initiatives within key enterprise accounts. Leverage your expertise to identify opportunities, influence solution strategies, and serve as a trusted advisor...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $100K *

Elevate your sales career by building lasting client relationships and driving revenue growth. This role focuses on strategic account management, fostering connections, and leveraging a dedicated mark...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$94K - $151K *

Join a team that's shaping the future of insurance products by leading strategic initiatives, ensuring compliance, and driving market analysis. Collaborate with product managers to define vision and e...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $141K *

Join us to enhance Business Continuity Management systems through innovative solutions, ensuring compliance and effective automation. Collaborate with teams to optimize processes and provide technical...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Join a team that's redefining creative operations! Lead resource management, optimize workflows, and foster collaboration across teams to deliver exceptional creative solutions for clients in a dynami...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$139K - $213K *

Grow your career with a dynamic team focused on driving strategic sales in the education sector. Leverage your expertise to engage C-suite executives, manage complex sales cycles, and exceed quotas wh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.