Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$174K - $291K *

Lead strategic initiatives to drive revenue growth across federal civilian agencies. Manage complex sales cycles, build customer relationships, and coordinate cross-functional teams to align solutions...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Shape the future of executive recruitment by leading strategic sourcing, engaging high-level candidates, and collaborating with a dedicated team to uncover top talent. This role offers growth opportun...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $145K *

Lead the charge in driving client success and commercial growth by managing strategic relationships, identifying upsell opportunities, and ensuring client satisfaction across a diverse portfolio in th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $100K *

Join a dynamic team as you craft precise architectural specifications, collaborating with architects to ensure high-quality project documentation and stay ahead of industry trends. Elevate your career...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$145K - $185K *

Champion the growth of Army Aviation business by identifying, shaping, and executing new opportunities. Build trusted relationships, lead contract execution, and drive portfolio success while managing...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $210K *

Lead mechanical design initiatives for construction projects, focusing on data centers. Collaborate with clients and teams to ensure high-quality delivery, manage project phases, and innovate solution...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $110K *

Transform your career by owning the technical execution of lifecycle and demand generation campaigns, leveraging HubSpot and Salesforce to drive data-backed improvements and seamless sales follow-up...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $130K *

Drive team performance and enhance customer experience by overseeing policy administration and contact center operations. Collaborate on goals, manage staffing, and ensure compliance with regulations...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in developing and executing channel strategies to drive growth, onboard high-performing partners, and enhance relationships with distributors in the life sciences sector...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$137K - $245K *

Lead the charge in driving strategic initiatives and product innovation within the Telematics Business Unit, enhancing core offerings and exploring new market opportunities through hands-on collaborat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$182K - $273K *

Inspire innovation as a Staff Product Marketing Manager bridging technical design and customer needs. Drive platform adoption through impactful messaging and competitive insights, enhancing market str...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$148K - $248K *

Shape the future of software sales by leading a dynamic team in the Southeastern US. Drive revenue growth, enhance customer relationships, and foster a high-performing culture while leveraging GitLab...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$72K - $99K *

Join a team that's dedicated to enhancing employee experience and office operations. You'll manage daily office functions, foster a vibrant culture, and support executive initiatives, ensuring a welco...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $154K *

Champion your career by managing change orders for large projects, evaluating contractual impacts, and ensuring effective communication with stakeholders. Collaborate with diverse teams to drive succe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Champion the development and execution of mission command training, mentoring unit leaders to enhance operational proficiency across various training domains. Collaborate with senior staff to ensure e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Unlock potential by managing month-end and year-end closes, ensuring accurate financial reporting across multiple entities. Collaborate with cross-functional teams to streamline processes and enhance...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$124K - $229K *

Join us to protect our players and platforms from advanced cyber threats. As a key member of our security team, you'll actively identify, investigate, and respond to security incidents, ensuring robus...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$150K - $180K *

Lead the growth and strategy of Home Services, overseeing HVAC, generators, and roofing. Drive sales, manage P&L, and build partnerships to enhance customer experience and operational efficiency in a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $120K *

Elevate your career by preparing and analyzing complex Medicaid cost reports, ensuring compliance with regulations, and leading a team of accountants in a remote setting. Drive process improvements an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$162K - $244K *

Elevate your career by leading an AI-driven digital marketing strategy that transforms pipeline generation and revenue growth. Drive innovation, optimize performance, and mentor a high-performing team...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $122K *

Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K *

Elevate sales strategies by owning the full sales cycle, building C-Suite relationships, and delivering impactful solutions to healthcare organizations across the Western US...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $175K *

Join a dynamic team to drive financial strategy and insights, ensuring sound decision-making across high-priority projects. Collaborate with leadership to optimize performance and support innovative p...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$136K - $160K *

Advance the software delivery process by managing launches and releases, ensuring accuracy and efficiency through automation and collaboration with cross-functional teams. Design workflows and tools t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.