Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Clinical Advisor, Age-Friendly Health Systems
$250K - $325K *
Unlock the potential of age-friendly health systems by providing strategic clinical leadership and guidance. Collaborate with health systems to implement the 4Ms framework, driving improvements in car...
1 week ago
Senior Project Manager Product
$110K - $130K *
Shape the future of product development by leading cross-functional teams to deliver innovative solutions from concept to launch, ensuring alignment with business goals and quality standards...
1 week ago
Supervising Physician - Dermatology (Remote)
$210K - $250K *
Lead the charge in providing remote clinical oversight for Dermatology PAs, ensuring high-quality patient care and compliance with regulations. Collaborate with a dedicated team to foster clinical exc...
1 week ago
$150K - $180K *
Lead the charge in engineering excellence, overseeing a team of 60 while driving AI initiatives and enhancing operational strategies. Collaborate with product leadership to elevate engineering practic...
1 week ago
$156K - $241K *
Oversee the management of demo environments, ensuring seamless integration and maintenance across departments. Collaborate with teams to deliver scalable technical architectures and optimize enterpris...
1 week ago
$125K - $150K *
Lead the charge in delivering innovative remedial systems design solutions. Collaborate with multidisciplinary teams, providing technical leadership and strategic direction for diverse environmental p...
Reposted 1 week ago
Director, Engineering- North America
$140K - $218K *
Transform the future of aerospace engineering by leading multi-site teams, enhancing technical capabilities, and driving operational excellence to meet customer demands and improve performance across...
1 week ago
Principal - Enterprise Applications
$116K - $150K *
Optimize SAP environments by leading migrations, ensuring system reliability, and implementing security measures. Contribute to project phases, from consulting to execution, while collaborating with d...
Reposted 1 week ago
Senior Software Engineer II, Applied AI
$125K - $150K *
Architect AI-driven solutions that automate workflows across teams, enhancing efficiency and productivity. Collaborate with diverse departments to design, deploy, and iterate on intelligent agents, sh...
1 week ago
Retail & Supply Chain Insights Advisor
$76K - $90K *
Optimize supply chain insights and capabilities, driving client value through data-driven storytelling and collaboration. Lead initiatives that enhance decision-making and foster partnerships, while m...
1 week ago
Quality Assurance System Tester
$85K - $141K *
Champion quality assurance processes and validate software capabilities through manual and automated testing to ensure reliability, security, and compliance for a large-scale agile software developmen...
Reposted 1 week ago
$110K - $130K *
Explore a pivotal role in transforming tax compliance into operational confidence. Collaborate with senior Sales Engineers to engage enterprise clients, addressing complex challenges and delivering ta...
1 week ago
$87K - $119K *
Drive customer engagement and retention while optimizing revenue growth through proactive account management and cross-functional collaboration. Ensure clients achieve high ROI and satisfaction throug...
Reposted 1 week ago
Revenue Cycle Managed Services - Billing Manager (Hospital System)
$100K - $120K *
Transform billing operations by leading a team to optimize healthcare revenue cycle processes, ensuring timely and accurate claims submission while driving performance improvements and fostering stron...
1 week ago
Civil Project Manager - Municipal
$95K - $115K *
Transform communities as a Civil Project Manager, leading project planning and execution while ensuring client satisfaction and budget adherence. Collaborate with a talented team to enhance municipal...
1 week ago
$150K - $180K *
Transform the future of quantum technology by leading product definition and architecture for a groundbreaking initiative. Collaborate with cross-functional teams to shape solutions and drive market e...
1 week ago
$80K - $90K *
Lead the visual narrative of client brands by delivering exceptional design solutions across multiple channels. Collaborate with diverse teams to uphold high standards and participate in innovative pr...
Reposted 1 week ago
$90K - $110K *
Transform complex clinical data into compelling copy that resonates. Collaborate with cross-functional teams to create impactful healthcare campaigns, ensuring accuracy and brand voice across diverse...
1 week ago
Senior Manager, Integrated Intelligence
$85K - $105K *
Shape impactful insights through analytics, driving data-informed decisions for healthcare clients. Collaborate with cross-functional teams to enhance marketing performance and audience understanding...
Reposted 1 week ago
Account Director, Promotional Medical Education
$100K - $120K *
Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...
Reposted 1 week ago
Marketing Manager (Entertainment & Commercial)
$80K - $95K *
Lead the marketing strategy for our Entertainment and Commercial team, managing projects from conception to execution. Collaborate with cross-functional teams to create impactful sales materials, supp...
1 week ago
Business Analytics Engineer, Customer Insights
$100K - $120K *
Lead the charge in transforming healthcare analytics by building robust data models and dashboards. Collaborate with diverse stakeholders to deliver actionable insights, ensuring data quality and clar...
1 week ago
$80K - $95K *
Transform the workplace by aligning HR strategies with business goals. Collaborate with leaders to enhance employee engagement, manage complex relations, and drive compliance while supporting multiple...
1 week ago
$110K - $130K *
Unlock developer potential by creating engaging content, organizing events, and fostering community connections. Collaborate with cross-functional teams to enhance user experience and advocate for dev...
1 week ago
$90K - $100K *
Join a team that's dedicated to driving client success through strategic marketing engagement. You'll manage client relationships, enhance platform adoption, and collaborate cross-functionally to achi...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.