Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$120K - $145K *

Transform the data platform by owning product direction and delivery. Collaborate across teams to prioritize needs, streamline processes, and ensure engineering focuses on impactful projects while enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $331K *

Empower your career by leading a dynamic team of medical professionals, driving strategic initiatives, and ensuring compliance in a fast-paced environment. Collaborate on impactful projects while fost...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion exceptional research outcomes by guiding clients through complex projects. Leverage your expertise in methodology and analysis to deliver actionable insights, while collaborating with cross-f...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$175K - $190K *

Innovate the deployment process by leading two squads to ensure seamless integration and self-service capabilities for customers, driving measurable outcomes and enhancing product effectiveness in a d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive your career with a Senior Program Analyst role focused on solving complex cross-functional challenges. Utilize analytical skills to enhance pricing, agreements, and program performance while col...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$177K - $195K *

Engage with healthcare professionals to build relationships and provide education on HAE treatment. Drive access support and promote Donidalorsen while collaborating with cross-functional teams to enh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead strategies to drive environmental due diligence growth, manage key client relationships, oversee project execution, and ensure delivery of high-quality results through effective team leadership a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Technical Services

$112K - $145K *

Drive GTM Analytics within Revenue Strategy, shaping performance metrics, data governance, and analytical support for strategic decisions. Collaborate with cross-functional teams to enhance channel ec...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$220K - $290K *

Elevate the user experience in healthcare by leading design innovation! You'll spearhead our design strategy, fostering a high-performance team while simplifying complex workflows into intuitive, beau...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$79K - $106K *

Join a team that's dedicated to protecting agriculture and natural resources. As an Attorney, you'll provide legal counsel, ensure regulatory compliance, and represent the department in legal proceedi...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Deliver exceptional consulting services by managing client implementations, diagnosing technical issues, and providing tailored solutions. Collaborate with cross-functional teams to ensure seamless in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining event marketing by leading high-impact programs that enhance customer engagement and drive revenue. You'll strategize and execute user summits, trade shows, and field eve...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$73K - $132K *

Contribute to impactful environmental projects by analyzing data, preparing technical documents, and collaborating with multidisciplinary teams to support CERCLA investigations and remediation efforts...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Technical Services

$350K - $410K *

Transform your career by leading a high-impact sales team focused on enterprise SaaS. Drive revenue growth through effective mentorship, strategy execution, and building scalable processes while foste...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$150K - $180K *

Champion the future of quantum technology by leading innovative research initiatives. Collaborate with cross-functional teams to shape product development and measurement protocols, leveraging deep ex...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$265K - $295K *

Shape community engagement strategies to foster trust and collaboration with local stakeholders, ensuring Anthropic's infrastructure projects benefit the communities we serve while navigating complex...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$218K - $256K *

Drive the architectural vision for high-scale fund movement systems, enhancing reliability and scalability. Lead cross-functional initiatives that impact millions, ensuring financial integrity and ope...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Join a team that's driving enterprise growth by managing key accounts, expanding relationships, and executing strategic plans. Leverage your expertise to enhance customer value and influence major org...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $160K *

Advance AI engineering by designing LLM-powered systems and optimizing data retrieval architectures. Collaborate with cross-functional teams to enhance CoreStory's narrative intelligence platform with...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Transform healthcare engagement by building relationships with HCPs through digital interactions and telephone conversations, promoting products, and achieving sales goals while ensuring compliance wi...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Lead the charge in product innovation by managing the full lifecycle from ideation to launch. Collaborate with cross-functional teams to align technical and business goals, ensuring successful product...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$128K - $205K *

Drive go-to-market operations for product lines, transforming strategic inputs into actionable plans. Collaborate cross-functionally to enhance field execution and optimize customer engagement, ensuri...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $160K *

Drive client success in our lab network by managing relationships, ensuring renewals, and identifying growth opportunities. Collaborate across teams to enhance processes and improve client experiences...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $130K *

Partner with us to deliver strategic financial insights that drive business success through effective forecasting, budgeting, and performance analysis, enabling informed decision-making and enhancing...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Shape the future of financial technology by developing seamless web applications. Collaborate with a dynamic team to create high-quality software that enhances user experience and drives strategic inn...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.