Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Field Reimbursement Manager-Atlantic
$185K - $230K *
Shape the future of patient access by leading reimbursement strategies and support for rare disease therapies. Collaborate cross-functionally to enhance provider education and patient understanding, e...
1 week ago
$135K - $162K *
Lead enhancements in Salesforce HealthCloud to optimize solutions and integrations, collaborate with teams, and deliver scalable applications that ensure high-quality data and security compliance for...
Reposted 1 week ago
$125K - $150K *
Advance the future of pediatric health by leading medical strategy, safety, and clinical communications. Collaborate with healthcare providers and internal teams to enhance product development and ens...
1 week ago
Technical Revenue Accounting and Policy Manager
$143K - $169K *
Unlock potential by developing and maintaining ASC 606 revenue policies, ensuring compliance and accuracy in revenue recognition. Collaborate cross-functionally to shape contract structures and suppor...
Reposted 1 week ago
Senior Customer Success Manager
$94K - $118K *
Champion client success by managing strategic Enterprise accounts, driving growth through innovative solutions and collaboration. Leverage AI tools to transform workflows and enhance client relationsh...
1 week ago
Technical Product Manager, Data Platform
$120K - $145K *
Transform the data platform by owning product direction and delivery. Collaborate across teams to prioritize needs, streamline processes, and ensure engineering focuses on impactful projects while enh...
1 week ago
US Field Medical Affairs, Team Lead - Rheumatology/Dermatology
$210K - $331K *
Empower your career by leading a dynamic team of medical professionals, driving strategic initiatives, and ensuring compliance in a fast-paced environment. Collaborate on impactful projects while fost...
1 week ago
$80K - $95K *
Champion exceptional research outcomes by guiding clients through complex projects. Leverage your expertise in methodology and analysis to deliver actionable insights, while collaborating with cross-f...
1 week ago
Senior Product Manager, Integrations & Platform
$175K - $190K *
Innovate the deployment process by leading two squads to ensure seamless integration and self-service capabilities for customers, driving measurable outcomes and enhancing product effectiveness in a d...
1 week ago
$110K - $130K *
Drive your career with a Senior Program Analyst role focused on solving complex cross-functional challenges. Utilize analytical skills to enhance pricing, agreements, and program performance while col...
1 week ago
Rare Disease Account Specialist, Portland OR - Donidalorsen/ Dawnzera
$177K - $195K *
Engage with healthcare professionals to build relationships and provide education on HAE treatment. Drive access support and promote Donidalorsen while collaborating with cross-functional teams to enh...
1 week ago
Senior / Principal Due Diligence Growth Lead
$125K - $150K *
Lead strategies to drive environmental due diligence growth, manage key client relationships, oversee project execution, and ensure delivery of high-quality results through effective team leadership a...
Reposted 1 week ago
$112K - $145K *
Drive GTM Analytics within Revenue Strategy, shaping performance metrics, data governance, and analytical support for strategic decisions. Collaborate with cross-functional teams to enhance channel ec...
Reposted 1 week ago
$220K - $290K *
Elevate the user experience in healthcare by leading design innovation! You'll spearhead our design strategy, fostering a high-performance team while simplifying complex workflows into intuitive, beau...
Reposted 1 week ago
$79K - $106K *
Join a team that's dedicated to protecting agriculture and natural resources. As an Attorney, you'll provide legal counsel, ensure regulatory compliance, and represent the department in legal proceedi...
1 week ago
Professional Services Engineer
$100K - $120K *
Deliver exceptional consulting services by managing client implementations, diagnosing technical issues, and providing tailored solutions. Collaborate with cross-functional teams to ensure seamless in...
1 week ago
Senior Marketing Events Manager
$110K - $130K *
Join a team that's redefining event marketing by leading high-impact programs that enhance customer engagement and drive revenue. You'll strategize and execute user summits, trade shows, and field eve...
1 week ago
Environmental Scientist - Technical Reporting & Remediation
$73K - $132K *
Contribute to impactful environmental projects by analyzing data, preparing technical documents, and collaborating with multidisciplinary teams to support CERCLA investigations and remediation efforts...
Reposted 1 week ago
$350K - $410K *
Transform your career by leading a high-impact sales team focused on enterprise SaaS. Drive revenue growth through effective mentorship, strategy execution, and building scalable processes while foste...
Reposted 1 week ago
$150K - $180K *
Champion the future of quantum technology by leading innovative research initiatives. Collaborate with cross-functional teams to shape product development and measurement protocols, leveraging deep ex...
1 week ago
Community Engagement Manager, Data Centers (New York)
$265K - $295K *
Shape community engagement strategies to foster trust and collaboration with local stakeholders, ensuring Anthropic's infrastructure projects benefit the communities we serve while navigating complex...
1 week ago
Staff Software Engineer, Backend - FinHub (Transfers)
$218K - $256K *
Drive the architectural vision for high-scale fund movement systems, enhancing reliability and scalability. Lead cross-functional initiatives that impact millions, ensuring financial integrity and ope...
1 week ago
Strategic Account Director, Key Accounts
$150K - $180K *
Join a team that's driving enterprise growth by managing key accounts, expanding relationships, and executing strategic plans. Leverage your expertise to enhance customer value and influence major org...
1 week ago
$130K - $160K *
Advance AI engineering by designing LLM-powered systems and optimizing data retrieval architectures. Collaborate with cross-functional teams to enhance CoreStory's narrative intelligence platform with...
Reposted 1 week ago
Senior Regional Sales Consultant
$95K - $115K *
Transform healthcare engagement by building relationships with HCPs through digital interactions and telephone conversations, promoting products, and achieving sales goals while ensuring compliance wi...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.