Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$82K - $128K *

Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$172K - $229K *

Lead the charge in developing advanced motion planning algorithms for autonomous vehicles, ensuring safety and performance through rigorous design, testing, and cross-functional collaboration in dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$95K - $115K *

Engage in diverse remediation projects, leading design and implementation efforts while ensuring project success through effective management and client engagement in a collaborative environment...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Unlock potential by joining a dynamic team of actuaries focused on managing and optimizing defined benefit pension plans, ensuring compliance, and delivering accurate valuations in a fully remote envi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Champion ecosystem partnerships by managing relationships, driving co-selling efforts, and executing joint go-to-market strategies. Collaborate cross-functionally to ensure successful integration and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$187K - $257K *

Elevate global sales operations by leading forecasting, pipeline management, and productivity initiatives. Collaborate with sales leaders to enhance clarity and consistency, driving growth through inn...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$94K - $141K *

Shape the future of software delivery by crafting compelling messaging and positioning for regulated enterprises. Drive executive conversations with insights on compliance and AI governance, while equ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$185K - $230K *

Unlock potential by developing strategic access plans for community healthcare, ensuring streamlined reimbursement processes and compliance while collaborating with stakeholders to enhance patient acc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$198K - $233K *

Architect the roadmap for our Business Technology Services and Workato platform, driving integration and automation across systems. Collaborate with stakeholders to prioritize demands, ensuring scalab...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$198K - $233K *

Lead the charge in developing a robust content management system to enhance cross-functional workflows and publishing capabilities, fostering a high-performing engineering team dedicated to scalabilit...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Accelerate your career by leading cross-functional programs that drive strategic initiatives in healthcare and biotechnology. Leverage your expertise to enhance product development, compliance, and op...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Empower the clinical support team by coordinating complex cases, mentoring junior counselors, and enhancing protocols. Your expertise will drive effective communication and quality standards in geneti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$171K - $269K *

Lead the charge in defining and evolving data architecture and engineering standards for scalable, secure enterprise data platforms. Collaborate across teams to deliver reliable, actionable data produ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $170K *

Join us to bridge technology and clients in the mortgage industry. You'll engage directly with customers, develop solutions, and influence product direction while driving efficiency and innovation in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $140K *

Architect AI-driven solutions to enhance GTM operations, streamline workflows, and empower sales and support teams. Collaborate cross-functionally to automate processes, improve efficiency, and drive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$170K - $185K *

Champion technical sales execution across diverse domains, driving alignment with growth priorities. Lead a high-performing team, enhance customer outcomes, and provide strategic insights to elevate s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $230K *

Unlock the potential of innovative products by partnering with technical teams to design and deliver exceptional customer experiences in a dynamic, regulated environment. Your expertise will shape com...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Champion enterprise systems diligence and value creation engagements, assessing technology, processes, and infrastructure to drive operational excellence and strategic insights for investors and manag...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Champion innovative paid marketing strategies to drive growth, manage budgets, and optimize performance across channels. Collaborate with teams to connect efforts and achieve measurable results in use...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$68K - $113K *

Empower your career as a key partner to technology leaders, managing complex calendars, coordinating meetings, and crafting impactful presentations. Join a dynamic team dedicated to enhancing organiza...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Transform client engagements by leading functional solution design for Salesforce Marketing Cloud Next, integrating marketing strategy with data architecture to optimize multi-channel campaigns and en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $135K *

Join a team that shapes innovative medical strategies, driving excellence in healthcare content. Collaborate with experts, cultivate client relationships, and inspire teams to elevate project outcomes...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive the evolution of a cutting-edge CI/CD platform, integrating AI tools and leading a team of DevOps engineers. Own production releases and implement modern delivery practices to enhance software d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$167K - $176K *

Shape the future of design operations by driving program execution, leveraging AI for efficiency, and managing cross-functional partnerships to enhance creative workflows and deliver impactful design...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$95K - $115K *

Partner with us to drive sales operations excellence, ensuring effective workflows, data integrity, and actionable insights in a dynamic environment while supporting strategic initiatives and enhancin...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.