Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Construction Defect Claims Specialist
$110K - $140K *
Lead the resolution of complex construction defect claims while managing a diverse portfolio. Collaborate with teams to ensure compliance and strategic outcomes, enhancing operational efficiency and c...
1 week ago
Senior Machine Learning Engineer (Traditional ML & Financial Data) - Remote - USA
$125K - $150K *
Unlock potential by leveraging your expertise in traditional machine learning to design, develop, and optimize solutions for diverse clients, collaborating closely with teams to deliver impactful resu...
1 week ago
Account Specialist (Billings, MT)
$160K - $192K *
Engage healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring compliance and lever...
1 week ago
Account Specialist, Eugene, OR
$160K - $192K *
Engage with healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful relat...
1 week ago
Strategy Specialist, Wealth Solutions
$85K - $105K *
Join a team that drives strategic investment initiatives by engaging advisors, managing relationships, and advancing opportunities in alternative investments, ensuring success in a dynamic financial s...
Reposted 1 week ago
$160K - $200K *
Shape the future of creative leadership by setting visionary strategies, driving distinctive brand expressions, and empowering a talented team to deliver integrated, high-impact marketing campaigns th...
Reposted 1 week ago
$220K - $250K *
Drive the product roadmap for Unify Release Orchestration, enhancing developer experience while coordinating releases across multiple services, engaging customers, and leading initiatives for AI-nativ...
Reposted 1 week ago
$164K - $222K *
Lead the charge in crafting advanced game engine systems, ensuring optimal performance and player experience while collaborating with diverse teams to enhance gameplay and develop innovative solutions...
Reposted 1 week ago
Wellspect Regional Sales Manager - New York
$120K - $220K *
Shape the future of healthcare by leading a dynamic sales team in the Urology and Incontinence sector. Drive revenue growth, foster key relationships, and implement strategic initiatives to enhance ma...
Reposted 1 week ago
$80K - $95K *
Shape the future of tax strategy by leading complex engagements, mentoring staff, and enhancing processes within a collaborative environment, ensuring exceptional client service and operational effici...
1 week ago
Senior Machine Learning Engineer (Traditional ML & Financial Data) - Remote - USA
$125K - $150K *
Optimize machine learning solutions by leveraging traditional algorithms and financial data. Collaborate with clients to enhance product delivery and integrate seamlessly into teams, driving impactful...
1 week ago
Account Specialist (Altoona, PA)
$160K - $192K *
Transform commercial performance by engaging healthcare providers, driving product adoption, and collaborating with cross-functional teams to ensure patient access to innovative therapies across a def...
1 week ago
$160K - $192K *
Lead the charge in driving commercial performance by engaging healthcare providers, building relationships, and executing territory business plans to ensure patient access to innovative therapies and...
1 week ago
DIRECTOR, HELP DESK (EPIC Experience Strongly Preferred)
$149K - $299K *
Champion exceptional service delivery by leading Help Desk operations, ensuring high-quality support for members and stakeholders. Drive continuous improvement, operational excellence, and effective i...
1 week ago
Senior Field & Demand Generation Manager, North America
$130K - $150K *
Join us to lead North America's field and demand marketing efforts, driving pipeline and revenue through strategic programs and cross-functional collaboration with sales and marketing teams...
Reposted 1 week ago
Senior Product Manager- Agentic Commerce (Remote)
$120K - $145K *
Grow your career with a dynamic team as a Senior Product Manager, driving innovative digital commerce solutions. Leverage data to enhance customer experiences and collaborate across teams to deliver i...
1 week ago
$95K - $115K *
Elevate financial operations by overseeing budgeting, forecasting, and reporting. Collaborate with leadership to drive strategic insights and strengthen compliance while mentoring a dynamic finance te...
1 week ago
Group Product Manager - Corporate Systems
$182K - $240K *
Pioneer a high-impact Corporate Systems strategy, leading a dedicated Product Management team to transform internal platforms. Drive cross-functional initiatives in Finance, People, and Sales to deliv...
Reposted 1 week ago
$79K - $111K *
Drive impactful technology initiatives as a strategic IT Product Owner, collaborating with diverse teams to enhance clinical operations, improve patient experiences, and ensure regulatory compliance i...
1 week ago
RN - Registered Nurse - Med Surg Float Pool - Days
$66K - $99K *
Transform patient care by utilizing your nursing expertise in a collaborative environment. Provide individualized nursing care through assessment, planning, and evaluation while thriving in a supporti...
1 week ago
$110K - $130K *
Innovate at the intersection of healthcare and technology. In this role, engineer ML pipelines, enhance data reliability, and ensure production stability for healthcare information systems, impacting...
Reposted 1 week ago
Account Specialist (Shreveport, LA)
$160K - $192K *
Empower your career by driving commercial success as you engage healthcare providers, build relationships, and support innovative therapies in a dynamic, remote role focused on impactful patient outco...
1 week ago
Account Specialist (San Jose, CA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
1 week ago
Employee Benefits Senior Risk Advisor
$90K - $110K *
Build strategic sales pipelines to drive new business growth in employee benefits solutions, focusing on client relationships, prospecting, and customized solutions to meet diverse organizational need...
Reposted 1 week ago
Executive Recruiter - Public Pension Executive Director Search
$110K - $130K *
Unlock potential by leading executive searches for public pension organizations. Collaborate with leadership to define roles, engage top talent, and guide candidate assessments, ensuring a strategic f...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.