Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$94K - $118K *
Unlock your potential by managing a comprehensive benefits program, ensuring compliance, and enhancing employee experience. Collaborate with cross-functional teams to streamline operations and support...
1 week ago
Sr. CRA, FSP - Surgical / Medical Device - Central region
$130K - $133K *
Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...
1 week ago
Lead Information Systems Security Officer (ISSO) - Post-Quantum Cryptography
$105K - $155K *
Join a team that's dedicated to safeguarding critical systems through expert security management. Leverage your RMF knowledge to ensure compliance, drive remediation, and maintain robust security post...
Reposted 1 week ago
Principal Experience Designer - Visual Design & Design Systems
$190K - $315K *
Shape the future of visual design for an enterprise design system, leading the evolution of its visual language and guiding teams to create consistent, high-quality experiences across products and maj...
1 week ago
Founding Forward Deployed Engineer
$125K - $150K *
Unlock potential by leading the development of innovative AI solutions that transform complex learning workflows into impactful autonomous agents, collaborating closely with strategic clients to shape...
1 week ago
Staff Attack Engineer, External
$238K - $280K *
Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...
1 week ago
Senior Attack Engineer, External
$206K - $242K *
Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...
1 week ago
Mid-Enterprise Account Executive, East Coast
$200K - $250K *
Empower growth in the cybersecurity sector by driving sales, acquiring new accounts, and fostering strong customer relationships. Leverage your expertise to introduce innovative solutions and exceed s...
1 week ago
$90K - $110K *
Champion project success by leading Microsoft D365 implementations and website development. Collaborate with cross-functional teams to ensure compliance and deliver high-quality results while managing...
1 week ago
Staff Engineer - Connectors Power BU
$120K - $145K *
Accelerate progress at the forefront of power connector innovation, leading product development initiatives while driving cross-functional collaboration and mentoring engineering talent to deliver hig...
1 week ago
Senior Director, Medical Affairs Strategy & Launch--Hematology
$247K - $309K *
Unlock potential by leading medical strategy for hematologic malignancies. Collaborate cross-functionally to drive evidence generation, stakeholder engagement, and launch readiness, ensuring impactful...
1 week ago
Senior Director Product Management
$172K - $287K *
Join us to shape the future of pharmacy by leading product strategy and innovation. Drive growth and commercialization for a diverse portfolio of healthcare technology solutions, influencing enterpris...
Reposted 1 week ago
Project Management Lead, Science
$110K - $130K *
Drive project delivery excellence by architecting frameworks, managing resources, and synchronizing teams. Lead cross-functional initiatives, optimize processes, and mentor project managers to ensure...
1 week ago
Head of AI & Business Transformation
$150K - $180K *
Transform your career by leading AI initiatives that drive business growth and operational efficiency. Collaborate across functions to embed AI into Rho's core operations, shaping a future where AI en...
1 week ago
RFP: Human Resource Subject Matter Lead
$100K - $120K *
Develop and deliver a comprehensive HR training module for multi-entity organizations, focusing on election-year challenges. Collaborate with stakeholders to create engaging content that enhances HR p...
1 week ago
$135K - $160K *
Empower strategic growth by developing and executing multi-year partner strategies. Collaborate with sales and executive teams to enhance alliances, drive revenue, and foster innovation across North A...
1 week ago
Project Manager (MEP Engineering)
$130K - $170K *
Shape the future of capital projects by leading multi-discipline teams to deliver complex design packages, ensuring quality and client satisfaction across diverse sectors including healthcare and gove...
1 week ago
Senior Manager, Design Delivery - USA
$125K - $150K *
Accelerate progress at the forefront of AI factory design delivery, leading multidisciplinary teams to ensure successful project execution from concept to handover while balancing quality, cost, and o...
1 week ago
Senior Product Marketing Manager, Field Enablement
$130K - $150K *
Contribute to product success by bridging Product, Marketing, and Sales. Drive field enablement through effective messaging, training, and content creation, ensuring sellers and partners can confident...
1 week ago
$80K - $95K *
Drive customer success by fostering relationships, ensuring renewals, and identifying growth opportunities. Engage with key stakeholders to align solutions with evolving needs, enhancing satisfaction...
1 week ago
Manager, Customer Success - Property
$100K - $130K *
Drive customer success by leading a team of managers to enhance client experiences, ensuring value delivery and operational excellence in multifamily property management. Collaborate cross-functionall...
1 week ago
Care Manager RN - UM (Full-Time) Weekends (Remote)
$68K - $105K *
Advance healthcare quality by implementing utilization management strategies. Analyze data for provider enhancement and member satisfaction, while promoting efficient care delivery through collaborati...
Reposted 1 week ago
Senior Oncology Account Manager, Dallas East
$150K - $230K *
Accelerate your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovati...
1 week ago
Senior Oncology Account Manager, Jersey South
$150K - $230K *
Lead the charge in promoting innovative oncology solutions while building strong relationships with healthcare professionals. Drive performance goals and enhance patient access through strategic engag...
1 week ago
Senior Oncology Account Manager, Phoenix East
$150K - $230K *
Optimize your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.