Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Software Engineer, Identity
$166K - $242K *
Deliver secure, reliable backend systems that enhance user experiences across products. Own projects from design to deployment, collaborating with cross-functional teams to balance security and usabil...
Reposted 1 week ago
Senior Substation Physical Engineer - REMOTE WORK
$97K - $192K *
Lead innovative substation engineering projects, providing technical direction and mentorship to teams while ensuring high-quality deliverables for clients across the U.S. Collaborate on complex desig...
1 week ago
Senior Oncology Account Manager, Miami
$150K - $230K *
Transform patient care by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure timely access to thera...
1 week ago
$110K - $140K *
Empower customer success by leading onboarding, optimizing solutions, and driving value through technical expertise. Build trust and advocate for clients while enhancing service delivery and collabora...
1 week ago
Senior Oncology Account Manager, Boston North
$150K - $230K *
Lead the charge in advancing oncology care by building strong relationships with key stakeholders, driving product adoption, and ensuring patient access to innovative therapies in a dynamic biopharma...
1 week ago
Senior Oncology Account Manager, Raleigh
$150K - $230K *
Join a dynamic team as you manage oncology product promotions, build relationships with key stakeholders, and drive brand value through strategic engagement and innovative solutions in a competitive b...
1 week ago
$110K - $130K *
Lead the execution of complex client programs, ensuring timely delivery and budget adherence. Collaborate with cross-functional teams to drive accountability and clarity, while proactively managing ri...
1 week ago
$140K - $175K *
Empower scientific innovation by collaborating within product pods to develop and evaluate real-world evidence agents. Drive impactful research and ensure scientific rigor while partnering with indust...
1 week ago
$115K - $140K *
Accelerate progress at our organization by leading demand generation strategies, optimizing campaigns across various channels, and collaborating with cross-functional teams to drive qualified pipeline...
1 week ago
Staff/Principal AI Scientist - Virtual Tissue
$150K - $180K *
Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...
Reposted 1 week ago
$102K - $170K *
Accelerate progress at transforming data solutions by building production-grade assets. Leverage your expertise in data engineering and business fluency to create trusted, reusable data products that...
1 week ago
Database Support Engineer (US East)
$150K - $200K *
Shape the future of data solutions as a Database Support Engineer, driving customer success through onboarding, technical support, and collaboration with sales teams to enhance product adoption and op...
1 week ago
$150K - $251K *
Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...
1 week ago
Benefits Analyst, North America
$68K - $102K *
Drive your career with a dynamic role in global benefits administration, ensuring compliance and enhancing employee wellness programs. Collaborate with vendors and support Total Rewards initiatives wh...
Reposted 1 week ago
$115K - $130K *
Lead the charge in optimizing search channels for diverse clients, managing a global team while driving SEO, PPC, GEO, and AIO strategies. Ensure performance efficiency and deliver insightful reportin...
1 week ago
$210K - $250K *
Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...
1 week ago
$210K *
Lead the charge in managing IT projects for our enterprise payments ecosystem. Collaborate with technical teams to develop detailed project plans, ensuring successful execution and alignment with busi...
1 week ago
$94K - $118K *
Unlock your potential by managing a comprehensive benefits program, ensuring compliance, and enhancing employee experience. Collaborate with cross-functional teams to streamline operations and support...
1 week ago
Sr. CRA, FSP - Surgical / Medical Device - Central region
$130K - $133K *
Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...
1 week ago
Lead Information Systems Security Officer (ISSO) - Post-Quantum Cryptography
$105K - $155K *
Join a team that's dedicated to safeguarding critical systems through expert security management. Leverage your RMF knowledge to ensure compliance, drive remediation, and maintain robust security post...
Reposted 1 week ago
Principal Experience Designer - Visual Design & Design Systems
$190K - $315K *
Shape the future of visual design for an enterprise design system, leading the evolution of its visual language and guiding teams to create consistent, high-quality experiences across products and maj...
1 week ago
Founding Forward Deployed Engineer
$125K - $150K *
Unlock potential by leading the development of innovative AI solutions that transform complex learning workflows into impactful autonomous agents, collaborating closely with strategic clients to shape...
1 week ago
Staff Attack Engineer, External
$238K - $280K *
Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...
1 week ago
Senior Attack Engineer, External
$206K - $242K *
Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...
1 week ago
Mid-Enterprise Account Executive, East Coast
$200K - $250K *
Empower growth in the cybersecurity sector by driving sales, acquiring new accounts, and fostering strong customer relationships. Leverage your expertise to introduce innovative solutions and exceed s...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.