Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Mechanical Engineering Lead, NA
$175K - $190K *
Explore strategic leadership in mechanical engineering, guiding a team of experts to innovate and deliver top-tier data center solutions. Collaborate cross-functionally to shape engineering standards...
1 week ago
Director of Information Technology
$150K - $180K *
Elevate global IT service delivery by leading a dynamic team, enhancing operational continuity, and driving proactive solutions across multiple markets while collaborating with cross-functional partne...
1 week ago
Leader, Solutions Engineer, Splunk
$209K - $275K *
Elevate your career by leading and developing a high-performing Solutions Engineering team. Drive strategic alignment across functions, foster technical excellence, and implement innovative practices...
Reposted 1 week ago
Credit Risk Review - Strategic Insight Team Manager
$128K - $268K *
Lead the charge in transforming credit risk management through strategic oversight, multidisciplinary team leadership, and innovative solutions. Drive operational excellence and governance while ensur...
1 week ago
Senior Routing Engine Developer (CX Platform)
$120K - $145K *
Deliver innovative routing solutions for enterprise-scale contact centers. Design and build a robust routing engine that intelligently distributes interactions across various channels, ensuring high a...
1 week ago
Field Service Engineer - New England
$90K - $100K *
Join a team that's dedicated to delivering exceptional field service support for Bioprocess products. In this role, you'll ensure customer satisfaction through installations, repairs, and maintenance...
1 week ago
Principal Technical Product Manager
$138K - $165K *
Elevate your career by leading complex product initiatives across technical domains. Collaborate with cross-functional teams to drive strategic direction into actionable plans, ensuring measurable out...
1 week ago
$130K - $155K *
Join a dynamic team as a key partner in revenue operations, collaborating with sales leadership to drive growth, manage forecasting, and enhance business strategies across multiple units. Embrace inno...
1 week ago
$120K - $150K *
Lead the charge in developing strategic frameworks that translate business objectives into actionable insights. Collaborate cross-functionally to identify growth opportunities and influence decision-m...
1 week ago
$116K - $175K *
Join our team to oversee and enhance logistics operations for Dental products, ensuring efficient order fulfillment and distribution. Lead a dedicated team while collaborating with various departments...
1 week ago
Healthcare Regulatory Assurance Lead
$119K - $175K *
Optimize healthcare compliance by leading regulatory assurance efforts, ensuring adherence to HIPAA, HITECH, and HITRUST standards while collaborating with clinical leadership to maintain a defensible...
1 week ago
$90K - $115K *
Join a team that's dedicated to ensuring financial accuracy and integrity. In this role, you'll manage month-end close processes, support audits, and enhance accounting practices while mentoring junio...
1 week ago
Senior Oncology Account Manager, Boston South
$150K - $230K *
Champion your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...
1 week ago
Senior Oncology Account Manager, Orange County
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with healthcare stakeholders while driving performance goals and ensuring patient access to innovative therapies in a dynamic...
1 week ago
Senior Oncology Account Manager, Milwaukee
$150K - $230K *
Join a team that's dedicated to advancing oncology care by promoting innovative products and building strong relationships with healthcare professionals. Leverage your expertise to drive brand value a...
1 week ago
Senior Oncology Account Manager, Philadelphia
$150K - $230K *
Drive impactful oncology solutions by building relationships with key stakeholders. Leverage your expertise to exceed performance goals and enhance patient access to innovative therapies while managin...
1 week ago
Senior Oncology Account Manager, Cleveland
$150K - $230K *
Drive impactful oncology product promotion by building strong relationships with key stakeholders. Leverage clinical expertise and market insights to exceed performance goals while ensuring patient ac...
1 week ago
Senior Oncology Account Manager, Charlotte
$150K - $230K *
Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...
1 week ago
Senior Oncology Account Manager, Omaha
$150K - $230K *
Transform the future of oncology care by driving product success and building strong relationships with key stakeholders. Lead initiatives that enhance patient access and deliver innovative solutions...
1 week ago
Senior Oncology Account Manager, Des Moines
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand value in a competitive market. Lead strategic initiat...
1 week ago
$73K - $102K *
Drive innovative SAP solutions by developing and implementing Fiori applications, enhancing ABAP capabilities, and collaborating with teams to meet client needs in a dynamic environment...
1 week ago
$110K - $130K *
Transform KYC operations by leading a team focused on customer onboarding and due diligence. Drive policy ownership, manage complex cases, and enhance processes through collaboration with cross-functi...
1 week ago
Senior Architect, Professional Services
$170K - $220K *
Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...
1 week ago
$125K - $155K *
Grow your career with a dynamic team focused on designing and implementing scalable systems. Collaborate on complex projects, mentor peers, and drive technical excellence while contributing to impactf...
1 week ago
$128K - $188K *
Transform strategic growth initiatives by partnering with executives to solve complex challenges, drive alignment across teams, and enhance customer experiences in a fast-paced communications and AI l...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.