Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$175K - $190K *

Explore strategic leadership in mechanical engineering, guiding a team of experts to innovate and deliver top-tier data center solutions. Collaborate cross-functionally to shape engineering standards...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Elevate global IT service delivery by leading a dynamic team, enhancing operational continuity, and driving proactive solutions across multiple markets while collaborating with cross-functional partne...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$209K - $275K *

Elevate your career by leading and developing a high-performing Solutions Engineering team. Drive strategic alignment across functions, foster technical excellence, and implement innovative practices...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$128K - $268K *

Lead the charge in transforming credit risk management through strategic oversight, multidisciplinary team leadership, and innovative solutions. Drive operational excellence and governance while ensur...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$120K - $145K *

Deliver innovative routing solutions for enterprise-scale contact centers. Design and build a robust routing engine that intelligently distributes interactions across various channels, ensuring high a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $100K *

Join a team that's dedicated to delivering exceptional field service support for Bioprocess products. In this role, you'll ensure customer satisfaction through installations, repairs, and maintenance...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$138K - $165K *

Elevate your career by leading complex product initiatives across technical domains. Collaborate with cross-functional teams to drive strategic direction into actionable plans, ensuring measurable out...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$130K - $155K *

Join a dynamic team as a key partner in revenue operations, collaborating with sales leadership to drive growth, manage forecasting, and enhance business strategies across multiple units. Embrace inno...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Lead the charge in developing strategic frameworks that translate business objectives into actionable insights. Collaborate cross-functionally to identify growth opportunities and influence decision-m...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$116K - $175K *

Join our team to oversee and enhance logistics operations for Dental products, ensuring efficient order fulfillment and distribution. Lead a dedicated team while collaborating with various departments...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$119K - $175K *

Optimize healthcare compliance by leading regulatory assurance efforts, ensuring adherence to HIPAA, HITECH, and HITRUST standards while collaborating with clinical leadership to maintain a defensible...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $115K *

Join a team that's dedicated to ensuring financial accuracy and integrity. In this role, you'll manage month-end close processes, support audits, and enhance accounting practices while mentoring junio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Champion your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with healthcare stakeholders while driving performance goals and ensuring patient access to innovative therapies in a dynamic...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Join a team that's dedicated to advancing oncology care by promoting innovative products and building strong relationships with healthcare professionals. Leverage your expertise to drive brand value a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Drive impactful oncology solutions by building relationships with key stakeholders. Leverage your expertise to exceed performance goals and enhance patient access to innovative therapies while managin...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Drive impactful oncology product promotion by building strong relationships with key stakeholders. Leverage clinical expertise and market insights to exceed performance goals while ensuring patient ac...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Transform the future of oncology care by driving product success and building strong relationships with key stakeholders. Lead initiatives that enhance patient access and deliver innovative solutions...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand value in a competitive market. Lead strategic initiat...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$73K - $102K *

Drive innovative SAP solutions by developing and implementing Fiori applications, enhancing ABAP capabilities, and collaborating with teams to meet client needs in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Transform KYC operations by leading a team focused on customer onboarding and due diligence. Drive policy ownership, manage complex cases, and enhance processes through collaboration with cross-functi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $155K *

Grow your career with a dynamic team focused on designing and implementing scalable systems. Collaborate on complex projects, mentor peers, and drive technical excellence while contributing to impactf...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$128K - $188K *

Transform strategic growth initiatives by partnering with executives to solve complex challenges, drive alignment across teams, and enhance customer experiences in a fast-paced communications and AI l...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.