Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
Principal Grants Management Implementation Consultant, Higher Education
$140K - $210K *
Unlock the potential of Higher Education by designing and implementing Workday Grants Management solutions. Collaborate with mission-driven organizations to ensure accuracy and long-term success in gr...
1 week ago
Regional Health Physicist - South Central US
$110K - $151K *
Champion operational excellence by ensuring radiation safety and EHS compliance across cyclotron manufacturing and PET nuclear pharmacy facilities in the South Central US, while collaborating with cro...
1 week ago
Program Manager, Implementation (Launch)
$100K - $120K *
Transform healthcare delivery by leading program initiatives that drive partner success in value-based care. Utilize data-driven strategies to manage launch processes, ensuring alignment across teams...
1 week ago
$110K - $130K *
Elevate customer relationships by owning a strategic account portfolio, driving growth through consultative selling and collaboration across teams. This senior role demands proactive engagement and a...
1 week ago
$110K - $130K *
Deliver innovative solutions by managing complex programs, ensuring seamless execution and coordination across multiple contracts while leveraging extensive IT expertise and leadership skills to drive...
Reposted 1 week ago
$230K - $260K *
Redefine global compensation and benefits strategies to attract AI talent, ensuring fairness and scalability across 18 countries while collaborating with executives and leveraging AI for innovative re...
1 week ago
Sr Tech Support Engineer MI -1 (for medical imaging devices)
$80K - $95K *
Join a team that's dedicated to providing exceptional remote technical support for complex issues across our product lines. Collaborate with peers to resolve challenges and ensure customer satisfactio...
1 week ago
$110K - $130K *
Lead the charge in enhancing cloud security by conducting proactive reviews, managing complex incidents, and collaborating with cross-functional teams to improve detection and response mechanisms whil...
1 week ago
$80K - $88K *
Transform the claims process by analyzing Lost-Time Workers Compensation claims, ensuring timely resolutions while delivering exceptional service to clients across various industries. Join a dynamic t...
1 week ago
ARPA-H Business Financial Manager (BFM) - HSF/SSO
$120K - $170K *
Accelerate financial management for high-impact health research programs. Collaborate with diverse teams to develop budgets, analyze expenditures, and ensure compliance with federal regulations, drivi...
1 week ago
Lead Software Development Engineer in Test
$165K - $185K *
Accelerate progress at the forefront of test automation, driving quality and performance through innovative strategies and frameworks. Collaborate within an agile team to enhance product scalability a...
Reposted 1 week ago
$97K - $137K *
Transform quality assurance processes by leading automation testing initiatives, mentoring teams, and developing strategic test plans to ensure robust web-based applications meet user requirements and...
1 week ago
Account Executive, Enterprise (TOLA)
$231K - $340K *
Partner with us to drive sales of innovative cybersecurity solutions, cultivating strong client relationships and exceeding quotas in the TOLA territory. Leverage your expertise to deliver impactful s...
1 week ago
Account Executive, SLED (East)
$231K - $340K *
Drive success by selling Cyber Defense solutions to high-profile SLED accounts. Cultivate client relationships, exceed sales quotas, and provide insights to enhance product offerings while navigating...
1 week ago
$115K - $143K *
Unlock the potential of data by architecting scalable pipelines and driving analytics initiatives, mentoring engineers, and collaborating with cross-functional teams to enhance our data solutions in a...
Reposted 1 week ago
Commerce Media Strategist, Retail Media Networks DSP
$80K - $100K *
Champion your expertise to drive and optimize innovative commerce media strategies, ensuring client satisfaction and measurable success across diverse marketing channels in a fully remote environment...
1 week ago
Commerce Media Strategist, Retail Media Networks DSP
$80K - $100K *
Optimize marketing campaigns within the commerce media ecosystem, developing tailored omnichannel strategies to drive client success and satisfaction while leveraging data-driven insights for continuo...
1 week ago
Clinical Documentation Manager
$73K - $115K *
Unlock the potential of clinical documentation integrity by driving ICD-10-CM coding accuracy and enhancing provider education. Collaborate with cross-functional teams to support risk adjustment initi...
1 week ago
Staff Software Engineer – Data Acquisition
$140K - $173K *
Transform data acquisition processes by leading the development of high-performance ingestion pipelines. Collaborate across teams to ensure data quality, reliability, and security while shaping the fu...
1 week ago
Sales Manager, Expense Management
$105K - $124K *
Lead a dynamic team of sales professionals to drive growth in expense management solutions. Collaborate on strategy, nurture talent, and exceed sales goals while engaging with customers and bridging t...
1 week ago
$77K - $101K *
Execute strategic sales initiatives to drive growth in expense management solutions, engaging existing clients to enhance their financial operations through innovative payment processing and expense m...
1 week ago
$122K - $177K *
Unlock potential by leading HRIS strategy and optimization, overseeing a team to enhance Workday and UKG systems. Drive transformation and collaboration across HR, Finance, and Operations for impactfu...
1 week ago
Trial Delivery Management (Advanced)
$110K - $130K *
Lead the charge in managing complex projects within the pharmaceutical and biotech sectors, ensuring successful execution and delivery while mentoring teams and collaborating with stakeholders to achi...
1 week ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
1 week ago
Executive Director, Field Operations Strategy & Excellence
$246K - $332K *
Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.