Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
$92K - $115K *
Transform client data integration processes by designing, building, and testing seamless connections between systems. Collaborate with teams to ensure optimal performance and security while delivering...
1 week ago
$31K - $130K *
Empower clients on their debt relief journey by providing compassionate consultations. Utilize your expertise to navigate sensitive conversations, adapt to changing needs, and achieve performance goal...
1 week ago
$190K - $225K *
Elevate your career by joining a dynamic Conflicts Team, where you'll analyze complex conflict reports, advise on risk management, and enhance ethical practices in a fully remote environment, ensuring...
1 week ago
$86K - $97K *
Empower learners by designing innovative educational experiences that enhance cybersecurity training. Collaborate with experts to create engaging content and lead projects that meet diverse learning n...
1 week ago
Senior Procurement Administrator (Remote)
$110K - $130K *
Lead the charge in optimizing procurement processes for federal contracts, ensuring compliance and efficiency. Collaborate with stakeholders to source, negotiate, and manage vendor relationships, driv...
1 week ago
Sr. Subcontracts Administrator - Remote
$110K - $130K *
Elevate your career by managing full life cycle subcontract activities, ensuring compliance, and driving supplier performance. Collaborate with cross-functional teams to optimize procurement strategie...
1 week ago
$99K - $118K *
Transform your career by leveraging your clinical and coding expertise to defend appeals for healthcare claims. This role demands independent analysis, strong communication, and proficiency in AI tool...
1 week ago
$96K - $116K *
Champion innovative medical policy solutions by analyzing data, ensuring quality, and collaborating across clinical operations. Drive enhancements in payment policy management while supporting diverse...
1 week ago
$150K - $200K *
Develop innovative mobile solutions by owning architecture, delivery, and production. Collaborate with cross-functional teams to enhance user experience while ensuring reliability and security for mil...
1 week ago
Chief of Staff - Vice President of HIV, Hepatitis, and TB
$110K - $130K *
Join a dynamic team to drive strategic initiatives and enhance global health outcomes. Collaborate with senior leadership to synthesize complex data, manage special projects, and prepare impactful com...
Reposted 1 week ago
Vice President of Growth Marketing
$160K - $200K *
Unlock your potential as a strategic leader driving growth through innovative marketing strategies. Collaborate with teams to enhance demand generation and optimize performance, ensuring alignment wit...
1 week ago
Healthcare Capture and Opportunity Management Specialist
$80K - $95K *
Drive impactful strategies by leveraging research and insights to advance government health opportunities. Collaborate with leaders to enhance competitive positioning and secure meaningful work that b...
1 week ago
$95K - $105K *
Unlock your potential by analyzing revenue data, forecasting trends, and collaborating with partners to drive financial performance. This role is essential for strategic decision-making and ensuring o...
1 week ago
Sr Regional Manager - Contact Center Back Office Support - Patient Access
$72K - $94K *
Transform patient access operations by leading centralized support functions, optimizing workflows, and enhancing service quality across multiple regions. Drive continuous improvement and develop lead...
1 week ago
Sr. Product Operations Manager
$110K - $160K *
Drive your career with a strategic role in Product Operations, partnering with leaders to transform complex challenges into actionable insights, while enhancing cross-functional collaboration and leve...
1 week ago
Senior Product Manager (Insights & Action)
$158K - $208K *
Empower your career by leading innovative AI-driven product strategies. Collaborate with cross-functional teams to enhance user experiences and drive business outcomes through data-driven insights and...
1 week ago
Staff Bioinformatics Engineer, Clinical Applications
$134K - $179K *
Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...
1 week ago
Principal Engineer Team Lead, Simulation Infrastructure
$200K - $275K *
Lead and optimize cloud infrastructure for simulation frameworks, driving team performance and technical strategy. Collaborate cross-functionally to enhance validation processes and ensure robust soft...
Reposted 1 week ago
Senior Product Manager, Agent Identity Management
$150K - $190K *
Pioneer the future of agent identity management by owning product vision, strategy, and execution. Collaborate across teams to deliver scalable solutions that enhance security and trust in AI interact...
1 week ago
$62K - $103K *
Shape the future of client relationships by leading global capital markets administration for high net-worth clients. Drive strategic decisions, enhance client experiences, and ensure compliance while...
1 week ago
$81K - $100K *
Join a team that's dedicated to enhancing sales development through hands-on coaching, operational support, and leadership. Drive team performance and foster growth in a dynamic, metrics-driven enviro...
1 week ago
Manager, Quality Assurance (LTSS)
$104K - $143K *
Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...
1 week ago
Associate Business Development Manager
$115K - $165K *
Unlock potential by leading sales strategies in a dynamic environment, engaging with executive clients and driving innovative solutions across a diverse tech platform, while leveraging major accounts...
Reposted 1 week ago
Sr. Manager, Fintech Pricing Strategy & Economics
$120K - $145K *
Unlock potential by driving profitability strategies for Fintech partnerships. Collaborate with senior leaders to enhance pricing methodologies and financial analysis, ensuring alignment with MVB's st...
1 week ago
Senior Product Manager, Shared Hosting
$140K - $170K *
Join us to redefine the customer journey for our shared hosting platform, focusing on retention and user experience. You'll lead strategy and execution, ensuring customers thrive post-purchase and enh...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.