Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$86K - $97K *

Empower learners by designing innovative educational experiences that enhance cybersecurity training. Collaborate with experts to create engaging content and lead projects that meet diverse learning n...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Lead the charge in optimizing procurement processes for federal contracts, ensuring compliance and efficiency. Collaborate with stakeholders to source, negotiate, and manage vendor relationships, driv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Elevate your career by managing full life cycle subcontract activities, ensuring compliance, and driving supplier performance. Collaborate with cross-functional teams to optimize procurement strategie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$99K - $118K *

Transform your career by leveraging your clinical and coding expertise to defend appeals for healthcare claims. This role demands independent analysis, strong communication, and proficiency in AI tool...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$96K - $116K *

Champion innovative medical policy solutions by analyzing data, ensuring quality, and collaborating across clinical operations. Drive enhancements in payment policy management while supporting diverse...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $200K *

Develop innovative mobile solutions by owning architecture, delivery, and production. Collaborate with cross-functional teams to enhance user experience while ensuring reliability and security for mil...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Join a dynamic team to drive strategic initiatives and enhance global health outcomes. Collaborate with senior leadership to synthesize complex data, manage special projects, and prepare impactful com...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Unlock your potential as a strategic leader driving growth through innovative marketing strategies. Collaborate with teams to enhance demand generation and optimize performance, ensuring alignment wit...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$80K - $95K *

Drive impactful strategies by leveraging research and insights to advance government health opportunities. Collaborate with leaders to enhance competitive positioning and secure meaningful work that b...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $105K *

Unlock your potential by analyzing revenue data, forecasting trends, and collaborating with partners to drive financial performance. This role is essential for strategic decision-making and ensuring o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$72K - $94K *

Transform patient access operations by leading centralized support functions, optimizing workflows, and enhancing service quality across multiple regions. Drive continuous improvement and develop lead...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $160K *

Drive your career with a strategic role in Product Operations, partnering with leaders to transform complex challenges into actionable insights, while enhancing cross-functional collaboration and leve...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$158K - $208K *

Empower your career by leading innovative AI-driven product strategies. Collaborate with cross-functional teams to enhance user experiences and drive business outcomes through data-driven insights and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$134K - $179K *

Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $275K *

Lead and optimize cloud infrastructure for simulation frameworks, driving team performance and technical strategy. Collaborate cross-functionally to enhance validation processes and ensure robust soft...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Transportation

$150K - $190K *

Pioneer the future of agent identity management by owning product vision, strategy, and execution. Collaborate across teams to deliver scalable solutions that enhance security and trust in AI interact...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$62K - $103K *

Shape the future of client relationships by leading global capital markets administration for high net-worth clients. Drive strategic decisions, enhance client experiences, and ensure compliance while...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$81K - $100K *

Join a team that's dedicated to enhancing sales development through hands-on coaching, operational support, and leadership. Drive team performance and foster growth in a dynamic, metrics-driven enviro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$104K - $143K *

Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $165K *

Unlock potential by leading sales strategies in a dynamic environment, engaging with executive clients and driving innovative solutions across a diverse tech platform, while leveraging major accounts...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Unlock potential by driving profitability strategies for Fintech partnerships. Collaborate with senior leaders to enhance pricing methodologies and financial analysis, ensuring alignment with MVB's st...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $170K *

Join us to redefine the customer journey for our shared hosting platform, focusing on retention and user experience. You'll lead strategy and execution, ensuring customers thrive post-purchase and enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $210K *

Drive impactful projects as a Power Platform Consultant, collaborating with a dynamic team to deliver innovative solutions for high-profile clients while advancing your career with cutting-edge techno...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $200K *

Drive your career forward by leading centralized inside sales and customer experience teams. Shape strategies, enhance customer interactions, and foster growth across multiple brands while ensuring op...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$106K - $145K *

Join a team that's redefining healthcare packaging by innovating and developing sustainable solutions that protect products while reducing costs. Collaborate globally to enhance healthcare delivery th...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.