Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
$122K *
Join a team that's driving growth in the home care sector by securing corporate partnerships and expanding agency networks. This role requires strategic engagement with executive stakeholders to enhan...
1 week ago
Senior Cloud Systems Administrator
$109K - $159K *
Lead the charge in administering cutting-edge cloud technologies, focusing on AWS and Linux systems. Collaborate with development teams to enhance CI/CD pipelines while ensuring system security and re...
1 week ago
$110K - $130K *
Innovate and develop complex applications for federal clients, collaborating with teams to ensure high-quality solutions. Utilize modern technologies and best practices to enhance user experience and...
1 week ago
Senior Principal Architect - Enterprise Solutions Architecture
$183K - $255K *
Lead the charge in defining enterprise architecture strategies that drive modernization and transformation across technology domains, engaging stakeholders and mentoring teams to achieve excellence in...
1 week ago
Sr. Real Estate Development Manager
$120K - $160K *
Transform real estate opportunities by leading market evaluations, strategic planning, and cross-functional collaboration to optimize portfolio growth and cost management across multiple regions...
1 week ago
$180K - $220K *
Drive the product vision and strategy for integrated hardware and software ecosystems, overseeing complex technology development while leading a team of Product Managers to achieve growth and innovati...
1 week ago
Head of Product & Customer Experience
$150K - $180K *
Accelerate transformation by leading product strategy and customer experience. Drive innovation at the intersection of genomics and AI, shaping the future of personalized health while building a high...
1 week ago
Program Manager, Medical Communications
$70K - $105K *
Collaborate with cross-functional teams to drive project execution and operational excellence in medical communications. Leverage your project management skills to ensure timely delivery and high-qual...
1 week ago
$110K - $130K *
Inspire and elevate design excellence as you lead a talented team, setting and maintaining visual standards, driving innovative campaigns, and partnering cross-functionally to advance Dandy's brand an...
Reposted 1 week ago
Lab Point of Care Sales Specialist
$100K - $115K *
Unlock potential by providing vital sales support and presentations, driving customer integration and product utilization, while conducting market research to enhance offerings. Collaborate closely wi...
Reposted 1 week ago
Senior Oncology Account Manager, Dallas West
$150K - $230K *
Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...
Reposted 1 week ago
Regional Sales Manager, Federal System Integrators
$272K - $374K *
Empower our sales team to drive revenue growth by leading strategic engagements with Federal Systems Integrators. Utilize your expertise to craft account plans, build relationships, and navigate compl...
1 week ago
$80K - $120K *
Grow your career with a dynamic sales role, driving supply chain transparency for leading brands. Own the full sales cycle, engage senior stakeholders, and develop solutions that enhance customer valu...
1 week ago
Senior Oncology Account Specialist Prostate Cancer Santa Monica, CA
$108K - $250K *
Join a team that's dedicated to enhancing patient care by promoting innovative oncology solutions. You'll engage with healthcare professionals, drive product awareness, and leverage insights to streng...
Reposted 1 week ago
Technical Account Manager, Southeast
$103K - $141K *
Take ownership of customer success by driving adoption and value realization of the platform. Leverage your technical expertise to guide clients through onboarding and operationalization, ensuring sat...
1 week ago
$120K - $145K *
Join a team that's shaping the future of Oracle Cloud solutions. As a key architect, you'll design and implement innovative Oracle CX applications, ensuring alignment with business goals while leading...
1 week ago
Commercial Business Development Representative
$100K *
Unlock potential by driving enterprise account strategies and engaging technical leaders. Collaborate with AEs to create meaningful outreach and build a pipeline that converts, focusing on quality int...
1 week ago
Director of Product Management, Platform
$183K - $230K *
Lead the charge in shaping our platform strategy, overseeing integrations, pricing, and customer experience. Collaborate with cross-functional teams to enhance product offerings and drive growth in a...
1 week ago
Regional Sales Director - Northwest
$180K - $215K *
Unlock regional growth by leading a high-performing sales team, executing launch strategies, and fostering key customer relationships in a dynamic, fast-paced environment. Drive performance and ensure...
1 week ago
Regional Sales Director - Cleveland
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Leverage strong business acumen and collaborative skills to achieve sale...
1 week ago
Senior Insider Threat Investigator - Remote
$110K - $130K *
Drive the Insider Threat Program by leading complex investigations, analyzing risks, and enhancing detection capabilities. Collaborate with cross-functional teams to mitigate insider threats and stren...
1 week ago
Regional Sales Director - Upstate NY
$180K - $215K *
Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...
1 week ago
Medical Director, Gastroenterology
$210K - $250K *
Unlock potential by leveraging your GI expertise to enhance product development, strengthen customer relationships, and drive growth in a dynamic SaaS environment. Collaborate across teams to deliver...
1 week ago
Sr. Manager, Project Management Office
$115K - $135K *
Join us to build and scale a high-performing PMO, leading project management initiatives while developing talent and establishing processes that enhance client delivery and satisfaction in the public...
1 week ago
$80K - $95K *
Shape the future of client strategy by leading growth initiatives, managing relationships, and driving performance metrics. Collaborate across teams to enhance brand success and ensure seamless execut...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.