Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$150K - $180K *

Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $109K *

Support the development of competitive proposals for utility-scale renewable energy projects. Collaborate with cross-functional teams to create innovative electrical solutions from opportunity identif...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Elevate your career by building strategic partnerships in the AI ecosystem. Collaborate with customers to tackle complex AI training challenges and shape innovative solutions, driving growth for a pio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $104K *

Empower a high-performing sales team by leading, coaching, and optimizing processes to exceed targets. Drive operational excellence and foster a collaborative culture while ensuring seamless customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform the future of hygienic sensors by leading product strategy, collaborating with engineering, and driving market success. Engage with customers and stakeholders to ensure product alignment wit...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$77K - $101K *

Join a team that's dedicated to optimizing licensing and renewals. Leverage your expertise in VMware/Broadcom to enhance customer retention and drive sales growth through effective account management...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$134K - $205K *

Join a team that's shaping the future of high-voltage transmission design. Lead projects, mentor talent, and ensure compliance with industry standards while delivering innovative solutions for clients...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$134K - $205K *

Explore a pivotal role in designing high-voltage transmission lines, mentoring teams, and ensuring compliance with engineering standards. Collaborate with clients and lead design activities to deliver...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$85K *

Champion the development and oversight of ABA treatment plans while mentoring a dedicated team of Behavior Technicians, ensuring effective collaborations with diverse families for impactful therapeuti...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive IT Service Management excellence by overseeing ServiceNow integration and support for critical U.S. Government missions. Collaborate with stakeholders to enhance ITSM processes and ensure effect...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $140K *

Lead a dynamic team to design and develop innovative front-end solutions using React and TypeScript. Mentor engineers, drive technical direction, and ensure high-quality software delivery in a collabo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$210K - $230K *

Lead the charge in driving growth and performance across multiple channels, optimizing customer journeys and aligning cross-functional teams to achieve measurable outcomes in MRR and product expansion...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$169K - $282K *

Join a team that's redefining oncology clinical operations by leading a dynamic portfolio of studies. Drive excellence in delivery, manage complex projects, and mentor a talented team to ensure high-q...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in shaping brand experiences across diverse touchpoints, from digital to in-person activations. Own projects from concept to delivery while fostering collaboration and innovation withi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$79K - $117K *

Join a team that's driving sales success in the North-East market by cultivating strong partnerships with distributors and end-users, leveraging value selling techniques to exceed goals and enhance cu...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Lead the charge in crafting immersive environments that elevate gameplay and storytelling. Collaborate with teams to create high-quality, modular assets that meet artistic and technical standards, sha...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$120K - $145K *

Elevate your career by leading the architecture and design of Oracle Cloud CX solutions. Collaborate with teams to translate business needs into scalable customer service portals while ensuring alignm...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$144K - $288K *

Empower product innovation by leading analytics development, defining strategies, and collaborating with cross-functional teams to enhance patient care and drive impactful solutions in a dynamic envir...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$123K - $164K *

Drive end-to-end design execution for major data center projects, leading multidisciplinary teams to ensure alignment with safety, sustainability, and commercial goals throughout the project lifecycle...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$180K - $215K *

Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$103K - $160K *

Unlock potential by driving profitable growth in the polymer business through strategic sales initiatives and customer engagement in the CASE and Powder Resins markets...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$103K - $123K *

Lead the growth of a sales territory by building relationships and generating premium. Own your pipeline and leverage existing partnerships while prospecting new agencies. Drive results with autonomy...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$146K - $203K *

Optimize enterprise-wide business continuity management by leading the development and implementation of a robust BCM framework, ensuring critical services are maintained and recovery capabilities are...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.