Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $119,100
$150K - $180K *
Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...
1 week ago
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
1 week ago
$75K - $109K *
Support the development of competitive proposals for utility-scale renewable energy projects. Collaborate with cross-functional teams to create innovative electrical solutions from opportunity identif...
1 week ago
AI Training Partnerships Manager
$110K - $130K *
Elevate your career by building strategic partnerships in the AI ecosystem. Collaborate with customers to tackle complex AI training challenges and shape innovative solutions, driving growth for a pio...
1 week ago
Supervisor, Inside Sales Representative - Remote, USA (Eastern Time Zone)
$75K - $104K *
Empower a high-performing sales team by leading, coaching, and optimizing processes to exceed targets. Drive operational excellence and foster a collaborative culture while ensuring seamless customer...
1 week ago
$110K - $130K *
Transform the future of hygienic sensors by leading product strategy, collaborating with engineering, and driving market success. Engage with customers and stakeholders to ensure product alignment wit...
1 week ago
Licensing Sales Specialist - VMware Broadcom
$77K - $101K *
Join a team that's dedicated to optimizing licensing and renewals. Leverage your expertise in VMware/Broadcom to enhance customer retention and drive sales growth through effective account management...
1 week ago
Lead EHV Transmission Line Engineer 2 - Grid
$134K - $205K *
Join a team that's shaping the future of high-voltage transmission design. Lead projects, mentor talent, and ensure compliance with industry standards while delivering innovative solutions for clients...
1 week ago
Lead Transmission Line Engineer 2 - Grid
$134K - $205K *
Explore a pivotal role in designing high-voltage transmission lines, mentoring teams, and ensuring compliance with engineering standards. Collaborate with clients and lead design activities to deliver...
1 week ago
$85K *
Champion the development and oversight of ABA treatment plans while mentoring a dedicated team of Behavior Technicians, ensuring effective collaborations with diverse families for impactful therapeuti...
Reposted 1 week ago
IT Service Management Specialist
$80K - $95K *
Drive IT Service Management excellence by overseeing ServiceNow integration and support for critical U.S. Government missions. Collaborate with stakeholders to enhance ITSM processes and ensure effect...
1 week ago
Lead Front-End Engineer (React, TypeScript and MUI)
$120K - $140K *
Lead a dynamic team to design and develop innovative front-end solutions using React and TypeScript. Mentor engineers, drive technical direction, and ensure high-quality software delivery in a collabo...
1 week ago
$210K - $230K *
Lead the charge in driving growth and performance across multiple channels, optimizing customer journeys and aligning cross-functional teams to achieve measurable outcomes in MRR and product expansion...
1 week ago
Director of US Oncology Portfolio Delivery
$169K - $282K *
Join a team that's redefining oncology clinical operations by leading a dynamic portfolio of studies. Drive excellence in delivery, manage complex projects, and mentor a talented team to ensure high-q...
Reposted 1 week ago
$110K - $130K *
Lead the charge in shaping brand experiences across diverse touchpoints, from digital to in-person activations. Own projects from concept to delivery while fostering collaboration and innovation withi...
1 week ago
$79K - $117K *
Join a team that's driving sales success in the North-East market by cultivating strong partnerships with distributors and end-users, leveraging value selling techniques to exceed goals and enhance cu...
1 week ago
$100K - $120K *
Lead the charge in crafting immersive environments that elevate gameplay and storytelling. Collaborate with teams to create high-quality, modular assets that meet artistic and technical standards, sha...
1 week ago
Oracle Cloud CX Architect - DCS & Service
$120K - $145K *
Elevate your career by leading the architecture and design of Oracle Cloud CX solutions. Collaborate with teams to translate business needs into scalable customer service portals while ensuring alignm...
1 week ago
Regional Sales Director - Birmingham
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...
1 week ago
Lead Director - Digital Product (Causal Analytics)
$144K - $288K *
Empower product innovation by leading analytics development, defining strategies, and collaborating with cross-functional teams to enhance patient care and drive impactful solutions in a dynamic envir...
Reposted 1 week ago
Senior Design Manager, Data Centers
$123K - $164K *
Drive end-to-end design execution for major data center projects, leading multidisciplinary teams to ensure alignment with safety, sustainability, and commercial goals throughout the project lifecycle...
1 week ago
Regional Sales Director - San Francisco
$180K - $215K *
Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...
1 week ago
$103K - $160K *
Unlock potential by driving profitable growth in the polymer business through strategic sales initiatives and customer engagement in the CASE and Powder Resins markets...
1 week ago
$103K - $123K *
Lead the growth of a sales territory by building relationships and generating premium. Own your pipeline and leverage existing partnerships while prospecting new agencies. Drive results with autonomy...
1 week ago
Business Continuity Management Lead
$146K - $203K *
Optimize enterprise-wide business continuity management by leading the development and implementation of a robust BCM framework, ensuring critical services are maintained and recovery capabilities are...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.