Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$120K - $140K *

Join a team that's shaping brand strategy and creativity to drive business growth. You'll develop integrated campaigns, translate consumer insights into impactful marketing, and collaborate across tea...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$205K - $256K *

Pioneer new customer acquisition strategies, focusing on major U.S. retailers. Lead negotiations and establish profitable relationships while managing the full sales cycle from pursuit to launch, ensu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$184K - $356K *

Empower our team by designing and optimizing C++ software for ultra low-latency WebRTC streaming systems, driving innovation in real-time media applications and enhancing user experiences through adva...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $170K *

Join a team that's dedicated to advancing tuberculosis (TB) prevention and care. As a senior technical advisor, you'll lead innovative strategies, collaborate with global partners, and enhance TB prog...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$115K *

Help us streamline our People Operations by managing payroll, compliance, and employee relations. Collaborate cross-functionally to build scalable systems and support our growing team across multiple...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Play a key role in architecting and administering the HaloPSA platform, ensuring optimal design, integration, and reporting. Collaborate across teams to enhance workflows and drive efficiency while su...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $100K *

Manage and elevate NinjaTrader Live's social media presence, driving strategy and content creation across multiple platforms. Collaborate with teams to engage traders, enhance brand voice, and deliver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $192K *

Join a team that's driving commercial success by engaging healthcare providers, building relationships, and supporting innovative therapies. Your expertise will be pivotal in executing business plans...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $210K *

Transform your career by driving profitable business with enterprise clients. Leverage your underwriting expertise to manage complex accounts, mentor peers, and shape portfolio strategies while foster...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $140K *

Drive innovative media strategies for healthcare clients, leveraging audience insights and performance data. Collaborate with cross-functional teams to enhance planning processes and deliver impactful...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $190K *

Elevate client experiences by guiding them through complex immigration cases, managing legal strategies, and leveraging technology for efficiency. Collaborate with diverse clients, ensuring clear comm...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$104K - $123K *

Elevate your career as a strategic advisor to mid-market clients, driving growth and revenue. Manage your own portfolio, build lasting partnerships, and uncover new business opportunities in this dyna...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $175K *

Champion growth by managing key partner relationships, driving revenue expansion, and ensuring partner success through strategic enablement and collaboration. Leverage your expertise to foster long-te...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $140K *

Lead order management and deal desk activities, ensuring efficient sales operations across North America. Collaborate with cross-functional teams to structure complex deals, maintain compliance, and o...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

The Channel Partner Sales Manager at HiddenLayer is responsible for driving pipeline and revenue through strategic Value-Added Resellers (VARs) while collaborating closely with the direct sales team...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$64K - $96K *

Deliver exceptional nursing care by utilizing the nursing process to assess, plan, implement, and evaluate patient outcomes in home and facility settings, ensuring adherence to clinical standards and...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $150K *

Lead the charge in environmental policy analysis and compliance, ensuring adherence to NEPA and other regulations. Collaborate with agencies, conduct research, and draft reports to support sustainable...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$83K - $110K *

Lead operational excellence by managing complex training programs and enhancing processes for a statewide initiative, ensuring effective communication and client engagement while fostering a high-perf...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$87K - $110K *

Engage with customers to ensure their success through onboarding, training, and support. Build strong relationships, manage inquiries, and collaborate with teams to enhance customer satisfaction and d...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K *

Unlock growth by leading sales initiatives with financial intermediaries, developing strategies to enhance client relationships, and driving MFS Investment products across diverse channels to achieve...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K - $350K *

Transform complex AI research into scalable, reliable systems. Collaborate across teams to architect and enhance backend services, ensuring robust infrastructure for model training and data collection...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $101K *

Manage web production and optimize digital experiences by collaborating with stakeholders, executing content strategies, and analyzing performance metrics to enhance engagement across online platforms...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$75K - $90K *

Join a team that's focused on driving revenue growth through strategic partnerships. You'll build lasting relationships, identify upsell opportunities, and collaborate with internal teams to deliver t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Launch impactful B2B events by developing strategies, managing budgets, and executing flawless experiences. Collaborate with marketing leaders to enhance brand presence and foster relationships throug...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$121K - $142K *

Elevate automation in software engineering by building AI-driven tools and systems. Collaborate with a focused team to enhance reliability and speed in package and image management, shaping the future...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.