Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$80K - $95K *

Transform airport advertising environments by conducting site visits, developing signage concepts, and collaborating with design teams. This role combines hands-on fieldwork with creative design to en...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$125K *

Transform customer experiences as a key advocate and technical partner, driving onboarding, adoption, and success for Enterprise clients while collaborating across teams to ensure optimal outcomes and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$119K - $221K *

Support dynamic legal processes in tech sales by negotiating complex agreements. Collaborate with cross-functional teams, manage high volumes of transactions, and drive legal department initiatives wh...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$119K - $186K *

Lead the negotiation and administration of Branded & Specialty Rx contracts, ensuring alignment with business strategies and stakeholder interests. Collaborate with internal teams to optimize processe...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Unlock potential by leading the Oracle MFCS merchandising workstream, driving design and delivery for a seamless omnichannel experience. Collaborate with teams to optimize processes and ensure success...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$162K - $243K *

Join a team that's dedicated to advancing clinical trials through strategic oversight and collaboration. Lead project management efforts globally, ensuring quality, cost, and timeline objectives are m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Transform the future of military aviation by delivering high-quality flight and ground instruction. Collaborate with aircrew and support teams to ensure safe, efficient operations while mentoring pilo...

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$95K - $120K *

Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$70K - $95K *

Join a team that's driving business success by building relationships and selling comprehensive HR solutions to small and midsize companies. You'll manage your own pipeline, engage with decision-maker...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$89K - $119K *

Join the charge in managing complex litigated claims, guiding strategy, and negotiating settlements. Leverage your expertise to achieve timely resolutions while balancing costs and exposure in a dynam...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$107K - $182K *

Lead the charge in driving revenue and market presence for IBM i & AIX services. Collaborate across teams to optimize offerings, establish partnerships, and enhance engagement with clients, ensuring t...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Transform your career by driving new business growth and client success in a dynamic remote environment. Leverage your sales expertise to build strategic partnerships and exceed revenue targets while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in transforming innovative ideas into impactful AI-driven solutions for public health and medical research. Collaborate with diverse teams to develop MVPs that enhance scientific disco...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $220K *

Unlock potential by driving partner engagement and growth through strategic channel management. Lead initiatives to onboard and enable partners, ensuring alignment with business objectives while foste...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$245K - $310K *

Champion innovative financing solutions as a strategic legal leader, overseeing structured finance, capital markets, and corporate law. Drive legal execution and team growth while ensuring compliance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$155K - $165K *

Develop a cutting-edge data ecosystem as a Senior Data Engineer, enhancing analytics, reporting, and machine learning. Collaborate with cross-functional teams to create efficient pipelines and accessi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$140K - $175K *

Transform investment research by evaluating and integrating diverse datasets, enhancing AI-driven workflows, and driving strategic content initiatives to elevate platform value and user experience...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$95K - $110K *

Transform creative visions into reality by leading design projects, mentoring teams, and collaborating with clients. Drive strategic branding initiatives while ensuring high-quality deliverables in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$304K - $397K *

Transform strategic account growth by developing relationships and executing sales plans. Leverage AI insights to enhance client engagement and drive revenue through consultative selling and multi-yea...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$105K - $115K *

Innovate the future of Revenue Operations by enhancing systems and processes. Collaborate across teams to solve complex problems, build automation, and drive data insights while providing exceptional...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Engage with cross-functional leaders to elevate product strategy and execution. Drive innovation in product development, leveraging AI to enhance customer value and business performance across a diver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$216K - $325K *

Pioneer enterprise security initiatives, ensuring robust cybersecurity and compliance while enabling growth and innovation. Collaborate with cross-functional teams to protect information assets and dr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Join us to enhance the security posture of our production platform. As an Infrastructure Security Engineer, you'll drive remediation efforts, build security frameworks, and collaborate with teams to p...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Champion patient care by performing interventional radiology procedures under supervision. Collaborate with a multidisciplinary team to assess, diagnose, and manage health concerns, ensuring optimal o...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$64K - $134K *

Drive success by managing key accounts, ensuring revenue growth through strategic upselling and relationship building. Collaborate with clients and internal teams to deliver exceptional service and ac...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.