Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$129K - $173K *

Join a team that's redefining API integration by leveraging your expertise to guide customers in automating service processes. Collaborate with technical sellers and enhance API adoption through effec...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$104K - $176K *

Lead the operational strategy for partner ecosystems, managing processes and technology to enhance partner engagement and streamline workflows. Drive automation and data integrity while collaborating...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$73K - $110K *

Drive coding quality and compliance by analyzing data, supporting audits, and enhancing documentation practices. Collaborate with teams to ensure accurate coding and adherence to regulatory standards...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $125K *

Drive the operational health of mission-critical Appian environments, ensuring reliability and performance. Collaborate with cross-functional teams to manage configurations, deployments, and incident...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Lead complex project management initiatives across multiple channels in the pharmaceutical advertising sector. Oversee cross-functional teams, ensuring timely delivery within budget while mentoring ju...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$113K - $151K *

Join a team that's transforming digital marketing solutions by developing innovative strategies and engaging presentations for enterprise clients, while collaborating across functions to drive impactf...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$126K - $157K *

Drive your career forward by leading complex software projects, collaborating with diverse teams, and leveraging cutting-edge technologies to deliver high-quality solutions that meet client needs and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$117K - $152K *

Shape the future of data delivery by managing cross-functional initiatives, ensuring timely execution and governance of data and model projects while collaborating with diverse teams to enhance operat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $130K *

Drive the future of revenue accounting by ensuring accurate recognition and compliance with ASC 606. Collaborate cross-functionally to streamline processes, support complex deals, and maintain audit r...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Shape the future of financial leadership by overseeing accounting functions, ensuring compliance, and driving strategic initiatives to enhance financial performance and reporting accuracy within the o...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$63K - $112K *

Join a team that's dedicated to enhancing client relationships and driving sales growth through effective product presentations and customer feedback. Collaborate with marketing and sales staff to ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $140K *

Transform your career by driving impactful sales playbooks and incentive programs. Leverage Salesforce, SQL, and AI tools to automate processes and enhance pipeline generation in a collaborative, glob...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $100K *

Champion the social media landscape by managing content, engagement, and analytics across multiple brands. Drive strategic initiatives, enhance community interaction, and elevate brand narratives in a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$150K - $500K *

Develop and implement innovative mortgage solutions while maximizing client satisfaction. Collaborate with operations and technology teams to streamline processes and support high-volume loan producti...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $147K *

Shape your career by leading data integration initiatives that drive enterprise-wide consistency and governance. Collaborate with stakeholders to deliver trusted, scalable data products while ensuring...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$126K - $154K *

Unlock your potential as a Senior Accountant, driving financial accuracy and compliance. Collaborate across teams to enhance systems, oversee key accounting functions, and support audits in a dynamic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Unlock your potential by driving partner growth and strategic initiatives in a dynamic environment. Collaborate with cross-functional teams to enhance the partner ecosystem and accelerate revenue thro...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Transform security engineering practices by building resilient systems that enhance and automate security workflows, ensuring smooth operation across multiple environments while integrating AI-assiste...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$119K - $186K *

Advance your career by providing strategic legal counsel on data governance, privacy, and cybersecurity within a dynamic healthcare environment. Collaborate with cross-functional teams to drive compli...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Join a dynamic team to deliver high-level financial analysis and strategic insights across multiple business segments. Leverage your expertise to support senior leadership in capital markets and drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $156K *

Drive data excellence by leading analytics initiatives, enhancing governance, and integrating systems. Collaborate with leadership to deliver impactful insights and ensure compliance while leveraging...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$135K - $155K *

Explore a pivotal role in shaping client relationships and driving agency success. Lead complex projects, mentor teams, and leverage your marketing expertise to deliver impactful solutions in a dynami...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$360K - $495K *

Lead the charge in product management, driving strategy and execution across multiple product pillars. Build a high-performing team, establish operational excellence, and ensure customer-centric outco...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$75K - $90K *

Drive execution and optimization of analytics strategies, collaborating with diverse teams to enhance product development and operational performance using AI and data insights. Be a key partner in co...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Media

$110K - $130K *

Drive growth by selling our innovative platform to financial institutions. Manage complex, multi-stakeholder sales cycles, guiding clients through their AI journey while exceeding annual quotas in a c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.