Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$101K - $137K *

Contribute to transactional finance activities across the procure-to-pay lifecycle, ensuring accurate processing of financial transactions while supporting operational workflows and maintaining data i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$141K - $204K *

Drive strategic growth for DSD by leveraging data, analytics, and tools to enhance operational performance and achieve expansion goals. Collaborate with leadership to support initiatives that elevate...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $152K *

Transform executive support by leading a dynamic team of EAs, enhancing processes, and driving strategic initiatives that align with company goals while fostering a collaborative culture...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$136K - $214K *

Lead the charge in optimizing revenue operations by managing a dynamic team, enhancing forecasting processes, and ensuring data integrity across systems. Collaborate closely with sales leadership to d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$133K - $209K *

Lead the charge in optimizing deal structures and contract management, collaborating with cross-functional teams to streamline workflows and enhance the sales process. Your analytical skills will driv...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in managing our growth roadmap, ensuring seamless integration across marketing, data, and engineering teams while maintaining data integrity and optimizing performance metrics for succ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$250K - $400K *

Shape the future of AI by designing evaluation frameworks and feedback systems that enhance model performance. Collaborate across teams to translate research into scalable solutions, driving impactful...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K *

Drive growth in the childcare division by leading a team of specialists, enhancing client relationships, and refining operational processes to maximize program impact and scalability...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Reimagine banking operations by managing product roadmaps for Time Deposits and related applications. Collaborate with cross-functional teams to enhance customer experiences while ensuring compliance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$93K - $150K *

Drive impactful market research initiatives by leading client relationships, managing complex projects, and mentoring teams. Collaborate with stakeholders to deliver strategic insights that enhance de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$73K - $102K *

Lead ERP customization and implementation efforts, collaborating with stakeholders to align business needs with technical solutions. Drive project governance, manage client relationships, and ensure c...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $185K *

Champion innovative software solutions by leading complex projects, mentoring engineers, and driving technical excellence across teams. Collaborate on strategic initiatives to enhance reliability and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Champion integrated project management for complex pharmaceutical advertising, leading cross-functional teams to ensure timely delivery within scope and budget while mentoring junior staff and enhanci...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$136K - $204K *

Drive the development of AI and technology certification programs for law schools, enhancing legal education engagement and establishing Clio as a trusted partner in the academic community through inn...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$190K - $200K *

Elevate your career by driving sales strategy and execution for a dynamic SaaS portfolio. Lead a high-performing team to achieve revenue growth, optimize pipeline management, and enhance customer acqu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$95K - $115K *

Lead Protection & Controls projects from kickoff to closeout, ensuring high-quality engineering deliverables and effective customer coordination. Collaborate with teams to manage project risks and del...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$144K - $288K *

Lead the charge in transforming customer identity platforms, driving modernization and operational excellence while overseeing a multi-team engineering organization to enhance security and customer en...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$121K - $155K *

Empower individuals by providing evidence-based mental health support to patients aged 13+. Collaborate with a dedicated clinical team in a fully remote environment, enhancing patient care and profess...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $136K *

Join a team that's transforming healthcare by developing essential tooling and AI capabilities for engineers. This role spans software development, architecture, and collaboration in an Agile environm...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Lead the charge in shaping user experiences by driving product design strategy, mentoring teams, and collaborating with cross-functional partners to tackle complex enterprise challenges and enhance de...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$105K - $155K *

Join a team that's redefining social media in healthcare. Lead strategic initiatives, drive impactful campaigns, and mentor talent while collaborating with clients to elevate their social presence acr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$194K - $270K *

Shape the future of our strategic initiatives by leading high-impact projects that drive innovation and collaboration across teams. Partner closely with executive leadership to deliver measurable resu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in transforming product vision into market success by leveraging customer insights, strategic positioning, and cross-functional collaboration to drive impactful go-to-market strategies...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $140K *

Drive impactful design solutions for developer tools, collaborating closely with engineers and PMs. Own workflows from discovery to delivery, enhancing user experiences and contributing to a robust de...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$127K - $260K *

Transform your career by leading the design and implementation of a comprehensive learning ecosystem for Assurance teams, fostering high-performance and collaboration across the organization to enhanc...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.