Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Director, Brazoria County Opportunity Youth Reconnection Network
$80K - $95K *
Inspire community collaboration as a leader driving youth reconnection efforts. You'll unite diverse stakeholders to enhance education, training, and employment pathways for young people, ensuring las...
1 week ago
$160K - $200K *
Champion innovation as a Senior Software Engineer, driving full-stack solutions and leveraging AI tools to enhance IT lifecycle management. Collaborate with a dynamic team to deliver impactful softwar...
1 week ago
Territory Leader: St. Louis, Missouri
$80K - $95K *
Grow your career in pharmaceutical sales by building relationships in dermatology. This role involves extensive travel to engage with healthcare professionals, promote products, and achieve sales goal...
1 week ago
Software Engineer - Mercury Command
$122K - $176K *
Lead the charge in evolving a cutting-edge financial assistant, enhancing user experience through innovative features and AI integration while collaborating with cross-functional teams in a dynamic st...
1 week ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...
1 week ago
$110K - $130K *
Lead the charge in executing digital product initiatives for veterinary health. Collaborate across teams to prioritize backlogs, write user stories, and enhance user experiences, ensuring alignment be...
1 week ago
Medical Affairs Technology and Digital Innovation Director
$190K - $238K *
Transform your career by leading the digital strategy for Medical Affairs. Drive innovation, optimize processes, and enhance scientific communications through emerging technologies while collaborating...
1 week ago
HPE SLED Channel Manager - West
$115K - $184K *
Advance HPE's growth in the West by driving strategic initiatives, fostering partner engagement, and enhancing market share within the public sector ecosystem. Collaborate with key stakeholders to cre...
1 week ago
$138K - $200K *
Transform partner success by leading a high-performing team of Channel Managers. Drive growth through innovative strategies, coaching, and collaboration across Microsoft’s ecosystem to achieve measura...
1 week ago
Bone Access & DMAB Patient Experience Lead, Marketing Senior Manager
$149K - $202K *
Make your mark at the forefront of patient access marketing, leading strategies and initiatives to enhance the Bone portfolio experience. Collaborate cross-functionally to optimize access solutions an...
1 week ago
Specialty Representative/Senior Specialty Representative - Bone Health - Rapid City, SD
$89K - $155K *
Transform customer engagement by leveraging clinical expertise to drive product utilization and sales growth. Collaborate with medical professionals to navigate payer complexities and enhance patient...
1 week ago
Senior Manager, Data Science & Advanced Analytics
$170K - $190K *
Transform data into actionable insights by leading a team of data scientists and analysts. Drive advanced analytics initiatives, foster collaboration with stakeholders, and ensure high-quality deliver...
1 week ago
Executive Director, Strategic Accounts
$246K - $332K *
Transform healthcare by leading national strategic account management efforts. Drive partnerships with key institutions, enhance patient care, and foster cross-functional collaboration to achieve comm...
1 week ago
Senior Director, Commercial Analytics & Decision Science
$219K - $285K *
Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...
1 week ago
Distinguished Engineer, AI Security Systems (Remote)
$235K - $350K *
Transform the future of cyber defense by architecting cutting-edge AI systems that autonomously protect against real-world threats. Lead technical direction, mentor teams, and drive innovation from re...
1 week ago
Engineer II - Site Reliability, Kubernetes (Remote, EST)
$100K - $145K *
Elevate your career by managing Kubernetes clusters across diverse environments. Collaborate with senior engineers to automate processes, troubleshoot issues, and enhance platform performance while de...
1 week ago
Associate Counsel, Employment and Commercial
$110K - $130K *
Collaborate with HR and legal teams to provide comprehensive employment law support, drafting and negotiating contracts while ensuring compliance with regulations. Balance legal risks with business ob...
1 week ago
Director, Field Analytics, Hematology
$174K - $234K *
Shape the future of Hematology analytics by leading strategic insights and performance initiatives. Collaborate with cross-functional teams to enhance field execution and drive commercial success thro...
1 week ago
Senior Clinical Research Associate - Oncology
$105K - $140K *
Lead the charge in monitoring clinical study sites, ensuring data integrity and patient safety while collaborating with diverse teams to enhance study delivery and compliance with regulatory standards...
Reposted 1 week ago
$74K - $124K *
Elevate compensation strategies by transforming complex data into actionable insights. Collaborate with stakeholders to manage compensation programs, analyze trends, and recommend solutions that ensur...
1 week ago
Vice President, Franchise Sales Development - Extended Stay
$485K *
Transform franchise growth in the Extended Stay sector by leading strategic initiatives, managing a team of Regional Vice Presidents, and building key relationships to enhance development opportunitie...
1 week ago
$162K - $207K *
Lead the charge in implementing and optimizing SAP Vistex solutions, translating business strategies into technical architecture while managing cross-functional teams and project deliverables for enha...
1 week ago
CIAM & IDAM Services & Enablement Lead
$129K - $185K *
Unlock potential by leading the Customer Identity & Access Management function, overseeing CIAM platform operations, and driving identity strategy across global digital ecosystems while collaborating...
1 week ago
Professional (Senior) Sales Representative, Pain - New Orleans W, LA
$100K - $162K *
Unlock potential by developing effective strategies and relationships to drive sales growth in the territory, ensuring compliance with regulations and high levels of customer engagement through effect...
Reposted 1 week ago
Product Builder, Merchant Portal
$104K - $145K *
Elevate product development by defining, designing, and prototyping features for a merchant portal, leveraging AI tools and user feedback to enhance payment processing solutions rapidly and effectivel...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.