Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Head of Business Development - Biologics
$160K - $200K *
Accelerate growth in Biologics by leading global business development efforts, driving new market creation, and forging strategic partnerships. Collaborate across teams to implement data-driven strate...
1 week ago
$90K - $110K *
Innovate data solutions by developing complex reports and analyses to support senior management and client needs. Collaborate with teams to enhance data literacy and provide technical guidance across...
1 week ago
Staff Software Engineer, Audiences
$150K - $180K *
Lead the charge in developing scalable audience solutions by integrating predictive models and data workflows. Collaborate with cross-functional teams to enhance audience activation and ensure reliabl...
1 week ago
$80K - $85K *
Elevate your career by analyzing complex litigation claims, ensuring timely resolutions, and delivering exceptional client service in a dynamic, supportive environment. Join a global leader committed...
1 week ago
Senior Project Manager - South Carolina
$100K - $120K *
Transform your career by managing custom automation projects from design to delivery. Lead cross-functional teams, ensure customer satisfaction, and drive financial results while navigating complex pr...
1 week ago
$84K - $131K *
Unlock your potential as a key player in implementing SAP Manufacturing solutions. Collaborate with clients to optimize operations, enhance efficiency, and drive innovation in a dynamic consulting env...
1 week ago
Director, Health & Life Sciences Research/Communities - Remote
$125K - $140K *
Lead transformative healthcare initiatives by fostering client relationships, driving impactful research, and developing high-performance teams to achieve strategic goals and business growth...
1 week ago
$150K - $200K *
Shape the future of wealth management by leading investment strategies for High Net Worth clients. Drive AUM growth, manage portfolios, and deliver tailored investment solutions while collaborating wi...
1 week ago
Traveling Construction Superintendent
$90K - $120K *
Transform your career by leading field operations on diverse commercial construction projects nationwide. Oversee safety, scheduling, and subcontractor coordination from groundbreaking to closeout, en...
1 week ago
GEOINT Analyst (GIS Analyst/Cartographer)
$80K - $95K *
Transform geospatial data into impactful maps and applications, supporting intelligence operations. Collaborate with teams to analyze and visualize data, ensuring compliance with standards while enhan...
1 week ago
Staff Software Engineer: Database Reliability Engineering
$120K - $145K *
Champion the modernization of enterprise data tiers by automating database reliability engineering across hybrid cloud environments, enhancing performance, and ensuring high availability for mission-c...
1 week ago
Business Development Manager, Industrial
$95K - $115K *
Elevate your career by driving growth through strategic business development in the industrial sector. Collaborate with enterprise clients, build relationships, and close deals while leveraging innova...
1 week ago
Vice President, Presales & Solutioning - Remote, United States
$175K - $210K *
Lead a dynamic team to drive presales and solution architecture for enterprise transformation, shaping innovative technology solutions and enhancing client engagements while fostering a high-performin...
1 week ago
$125K - $150K *
Lead the charge in enterprise sales by hunting new logos within the Life Sciences sector. Build relationships with Salesforce partners to enhance co-selling opportunities while managing your own pipel...
1 week ago
Cloud Infrastructure Architect - Remote
$120K - $160K *
Drive the design and management of cloud infrastructure, ensuring secure, scalable systems that align IT operations with business goals. Lead initiatives in automation and DevSecOps to enhance operati...
1 week ago
$96K - $101K *
Empower domestic workers by leading impactful research initiatives that inform advocacy and policy development. Drive strategic research agendas, mentor a dedicated team, and collaborate with diverse...
1 week ago
Senior Actuarial Analyst: Commercial Lines - Remote
$92K - $135K *
Grow your career with a dynamic role providing actuarial support for commercial lines, managing projects, analyzing market trends, and ensuring compliance while advancing your actuarial expertise thro...
1 week ago
Director, Enterprise CRM Delivery - Remote, United States
$150K - $180K *
Manage delivery leadership for life sciences CRM transformation programs, ensuring high-quality implementations and migrations. Collaborate with cross-functional teams to meet client expectations and...
1 week ago
Commercial Sales and Project Support
$130K - $150K *
Elevate project success by managing the lifecycle of commercial sales initiatives. Collaborate across teams to ensure accurate documentation, financial oversight, and timely invoicing, driving efficie...
1 week ago
$132K - $153K *
Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...
1 week ago
Customer Success Director (Oracle Focused)
$100K - $125K *
Engage with strategic Oracle customers to drive success through relationship management, implementation guidance, and value realization. Champion customer outcomes and optimize their journey with Redw...
1 week ago
$200K - $240K *
Optimize global sales strategies to drive revenue growth and market leadership. Lead the transformation of sales functions into a cohesive, customer-centric organization, ensuring alignment with long...
1 week ago
$120K - $145K *
Champion the development of clinical operations by managing a network of providers, establishing policies, and enhancing quality programs. Collaborate with leadership to ensure operational excellence...
1 week ago
STRIDES Laboratory and Diagnostics Advisor, Outbreak Preparedness and Response
$89K - $120K *
Drive initiatives to expand and strengthen laboratory systems for outbreak response and public health, ensuring alignment with national policies and international standards while providing technical l...
Reposted 1 week ago
Sr Manager, Clinical Data Management
$143K - $185K *
Unlock potential by leading clinical data management for innovative cell therapy studies. Collaborate cross-functionally to ensure data integrity and compliance while managing teams and external partn...
Reposted 1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.