Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$100K - $125K *

Champion innovation by integrating AI tools into workflows, enhancing research and consulting capabilities. Collaborate across teams to develop AI products, drive adoption, and foster a culture of con...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$130K - $160K *

Drive AI-native sales by building C-suite relationships and closing enterprise deals. Collaborate with account owners to identify opportunities and educate prospects on financial orchestration's value...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Transform healthcare delivery by providing emergency and primary care at remote worksites. Collaborate with clinical teams to ensure quality assurance and support field staff while maintaining essenti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $200K *

Reimagine retail leadership as you drive sales growth and develop talent across multiple regions. Lead a team of Regional Directors to enhance patient relationships and execute strategic initiatives...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $95K *

Drive growth by identifying where US salon owners engage, creating impactful campaigns, and optimizing landing pages. Collaborate across teams to enhance Slick's presence in the beauty sector, leverag...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the charge in managing cross-functional programs that enhance AI data quality and evaluation. Collaborate with diverse teams to translate product needs into actionable plans, ensuring efficient d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Accelerate progress at the forefront of the electric utility industry by leading sales and customer relationships for innovative power solutions. Drive growth, forge partnerships, and deliver exceptio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$230K - $270K *

Shape the future of compliance technology by leading the design and implementation of data-driven solutions that meet global regulatory standards, ensuring operational efficiency and effectiveness acr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$121K - $164K *

Champion a team of analysts to enhance enterprise infrastructure services, ensuring reliable support and operational excellence. Collaborate with cross-functional teams to align priorities and drive c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Drive strategic transformation by leading Record-to-Report functions, enhancing service quality, and implementing best practices across Financial Systems Consulting to achieve world-class operational...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Accelerate progress at the forefront of financial close management solutions. Lead strategic initiatives, enhance operational efficiency, and drive client satisfaction while overseeing implementation...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Accelerate growth in Biologics by leading global business development efforts, driving new market creation, and forging strategic partnerships. Collaborate across teams to implement data-driven strate...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Innovate data solutions by developing complex reports and analyses to support senior management and client needs. Collaborate with teams to enhance data literacy and provide technical guidance across...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Lead the charge in developing scalable audience solutions by integrating predictive models and data workflows. Collaborate with cross-functional teams to enhance audience activation and ensure reliabl...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$80K - $85K *

Elevate your career by analyzing complex litigation claims, ensuring timely resolutions, and delivering exceptional client service in a dynamic, supportive environment. Join a global leader committed...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Transform your career by managing custom automation projects from design to delivery. Lead cross-functional teams, ensure customer satisfaction, and drive financial results while navigating complex pr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$84K - $131K *

Unlock your potential as a key player in implementing SAP Manufacturing solutions. Collaborate with clients to optimize operations, enhance efficiency, and drive innovation in a dynamic consulting env...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $140K *

Lead transformative healthcare initiatives by fostering client relationships, driving impactful research, and developing high-performance teams to achieve strategic goals and business growth...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$150K - $200K *

Shape the future of wealth management by leading investment strategies for High Net Worth clients. Drive AUM growth, manage portfolios, and deliver tailored investment solutions while collaborating wi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $120K *

Transform your career by leading field operations on diverse commercial construction projects nationwide. Oversee safety, scheduling, and subcontractor coordination from groundbreaking to closeout, en...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Transform geospatial data into impactful maps and applications, supporting intelligence operations. Collaborate with teams to analyze and visualize data, ensuring compliance with standards while enhan...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $145K *

Champion the modernization of enterprise data tiers by automating database reliability engineering across hybrid cloud environments, enhancing performance, and ensuring high availability for mission-c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Elevate your career by driving growth through strategic business development in the industrial sector. Collaborate with enterprise clients, build relationships, and close deals while leveraging innova...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$175K - $210K *

Lead a dynamic team to drive presales and solution architecture for enterprise transformation, shaping innovative technology solutions and enhancing client engagements while fostering a high-performin...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead the charge in enterprise sales by hunting new logos within the Life Sciences sector. Build relationships with Salesforce partners to enhance co-selling opportunities while managing your own pipel...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.