Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$135K - $160K *

Lead the design and implementation of complex Salesforce solutions in a multi-org federal environment. Drive modernization efforts and ensure compliance while providing technical leadership and mentor...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$229K - $258K *

Lead the charge in shaping product security strategy, driving cross-functional initiatives, and embedding security by design into engineering workflows. Collaborate with teams to enhance vulnerability...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $200K *

Drive profitable growth by underwriting middle market GL accounts in a non-admitted environment. Leverage strong broker relationships, evaluate risks, and mentor junior underwriters while ensuring com...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$175K - $210K *

Lead the technical strategy and pre-sales organization for AI infrastructure, driving complex enterprise deals and shaping product roadmaps through customer insights and architectural expertise...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $110K *

Optimize project delivery by leading complex life sciences research initiatives, ensuring timely execution, quality standards, and effective vendor management while collaborating with cross-functional...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$95K - $130K *

Lead the charge in overseeing field installation activities, ensuring safety and quality while coordinating with project managers and stakeholders to drive successful project execution and adherence t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $110K *

Lead the charge in shaping product marketing strategies for two dynamic markets. Collaborate with cross-functional teams to drive customer adoption, competitive positioning, and revenue growth while e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$250K - $300K *

Explore a rewarding career as a Diagnostic Radiologist, supporting growth in Wilkes-Barre and Scranton. Join a respected practice with modern technology, excellent procedural volume, and opportunities...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Accelerate sales growth by managing hardware and service functions across a designated territory. Drive project management and customer relationships to meet revenue and profitability goals while ensu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$105K - $163K *

Lead and manage client-facing teams to deliver high-quality card processing projects, ensuring successful implementations and client satisfaction through effective project management and strategic ove...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Transform software solutions by leading architecture and design efforts, mentoring teams, and driving modernization initiatives. Collaborate across divisions to enhance public services while ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$121K - $188K *

Pioneer the future of enterprise collaboration platforms, leading a team to enhance Microsoft 365 and ensure compliance for over 13,000 users. Drive innovation and strategic initiatives while managing...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $203K *

Drive impactful legal solutions by drafting and negotiating complex data contracts. Collaborate with cross-functional teams to support growth while managing risk in a fast-paced environment focused on...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$128K - $191K *

Lead impactful cost of service studies and rate design analysis for utilities across North America. Collaborate with clients, provide expert testimony, and manage projects to enhance utility operation...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$150K - $200K *

Join a dynamic team to conduct comprehensive eye exams and diagnose ocular conditions using innovative technology. Educate patients on eye care and develop personalized treatment plans in a hybrid wor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $212K *

Drive growth through innovative demand generation strategies, leveraging data and analytics to enhance pipeline performance. Collaborate with cross-functional teams to optimize marketing efforts and l...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$130K - $150K *

Shape your career by designing and developing integration solutions for complex SAP S/4HANA implementations, collaborating with teams to ensure seamless connectivity and robust interfaces that enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $120K *

Join us to lead field operations on government and infrastructure projects nationwide. Oversee construction activities, manage subcontractors, ensure safety compliance, and drive quality control for s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $170K *

Innovate with AI to enhance HR software. Design and develop scalable web services, lead initiatives, and mentor engineers while focusing on user experience and collaboration in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$203K - $253K *

Strategize and lead patient advocacy and medical education initiatives, fostering collaboration with stakeholders to enhance patient engagement and inform Medical Affairs strategies. Drive impactful i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Lead multi-discipline collection planning and execution to enhance border security operations. Collaborate with analysts and partners to translate intelligence requirements into actionable tasks, ensu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Unlock potential by conducting critical analysis on transnational threats, fusing multi-source intelligence, and producing actionable insights to enhance border security and inform strategic decision...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$149K - $205K *

Elevate innovation at the forefront of foodtech, agritech, and infrastructure. Lead strategic initiatives, build ecosystems, and drive new ventures to shape the future landscape of Mitsubishi Electric...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$126K - $153K *

Lead the charge in transforming healthcare safety cultures by applying High Reliability Organization principles, enhancing patient trust, and driving data-driven process improvements across clinical s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Transform customer relationships by driving strategic account growth, enhancing engagement, and achieving sales targets. Collaborate with cross-functional teams to meet client needs and deliver except...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.