Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Senior Consultant - Clinical Operations
$89K - $148K *
Drive your career with impactful consulting in healthcare, enhancing operational efficiency and financial performance for provider organizations through data analysis and project management...
1 week ago
$110K - $130K *
Join our dynamic team as you lead equity program operations, ensuring compliance and enhancing processes. You'll be the go-to expert for equity-related matters, driving initiatives that support our ra...
1 week ago
$216K - $228K *
Transform the research landscape by defining and leading user research practices that connect customer insights to product design across multiple foundational areas, driving high-quality deliverables...
1 week ago
$225K - $300K *
Shape the future of our global accounting function by leading the controllership organization, driving IPO readiness, and establishing robust financial controls to support a high-growth, multi-entity...
1 week ago
Full Stack Engineer (Go and React)
$110K - $130K *
Engineer innovative cloud-native applications, developing scalable backend services and modern web solutions using Golang and React. Collaborate with cross-functional teams to solve complex challenges...
1 week ago
$170K - $210K *
Engage as the senior creative leader, ensuring top-tier quality and performance across all creative outputs. Drive a culture of testing and learning while fostering strong client relationships and lea...
1 week ago
Engineering Manager, Data Streaming
$225K - $265K *
Accelerate progress at a mission-critical team, leading Data Streaming to enhance data ingestion pipelines. Build a skilled team, ensure pipeline reliability, and collaborate cross-functionally to sup...
1 week ago
$225K - $265K *
Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...
1 week ago
$95K - $115K *
Grow your career with a dynamic team focused on maximizing sales and building relationships in the specialty pharmaceutical sector. Drive strategic initiatives and collaborate across functions to achi...
1 week ago
Senior Advisor, Staff Well-Being and Workforce Resilience
$95K - $115K *
Transform staff well-being by leading strategic initiatives that enhance resilience and psychosocial support across diverse, high-stress environments, ensuring alignment with organizational priorities...
1 week ago
$80K - $100K *
Lead strategic sales initiatives to enhance Wireless, EMC, and Product Safety revenue. Cultivate new and existing customer relationships while driving technical discussions and solutions across divers...
1 week ago
CIAM Product Manager - Capabilities & Intelligence
$71K - $125K *
Lead the execution of CIAM strategy by optimizing authentication intelligence and fraud detection tools. Collaborate with cross-functional teams to enhance security, reduce friction, and drive data-in...
1 week ago
Senior Servicing Officer (Institutional Capital Group)
$71K - $125K *
Transform complex loan servicing processes as a Senior Servicing Officer, managing a diverse portfolio in commercial real estate. Contribute to client partnerships and lead initiatives, while expandin...
Reposted 1 week ago
$80K - $150K *
Unlock secure customer experiences by designing and implementing identity solutions. Collaborate with cross-functional teams to enhance authentication processes, ensuring seamless onboarding and login...
1 week ago
Sr. Manager Regulatory Affairs, Advertising & Promotion (Remote)
$150K - $245K *
Empower your career by leading regulatory advertising initiatives, ensuring compliance while collaborating with cross-functional teams to develop impactful product messaging for marketed and pipeline...
1 week ago
Manager Regulatory Affairs, Advertising & Promotion (Remote)
$128K - $210K *
Manage regulatory activities for advertising and promotion, ensuring compliance while collaborating with cross-functional teams to develop impactful product messaging and materials that align with com...
1 week ago
$150K - $190K *
Unlock potential by designing scalable data models and ensuring data quality. Collaborate with cross-functional teams to translate business needs into technical solutions, driving analytics excellence...
1 week ago
$75K - $95K *
Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...
1 week ago
$136K - $200K *
Champion employee advocacy by leading initiatives that enhance workplace relationships, drive positive employee experiences, and ensure effective communication across teams, while leveraging data anal...
1 week ago
$90K - $120K *
Champion customer success by driving engagement and building lasting relationships with enterprise clients. Collaborate across teams to ensure exceptional user experiences and achieve measurable outco...
1 week ago
Group Curriculum Manager, Science
$95K - $115K *
Lead a dynamic content development team to create high-quality curriculum materials for K-8 science education. Oversee project management, ensure content consistency, and drive team performance to mee...
1 week ago
$178K - $366K *
Shape the future of privacy compliance by providing strategic counsel to cross-functional teams, ensuring products meet EU regulations while balancing business goals. Drive scalable processes and lead...
1 week ago
Copy of Full Stack Software Engineer
$110K - $130K *
Engineer innovative data-driven web applications, bridging data engineering and analytics. Own end-to-end features, transforming complex data into user-friendly tools that enhance customer experience...
1 week ago
Field Reimbursement Manager - Central
$110K - $130K *
Drive patient access to Provenge by removing reimbursement barriers and collaborating with healthcare stakeholders. Develop strategies to enhance business growth while navigating complex payer policie...
1 week ago
$160K - $200K *
Drive operational excellence by leading a global team to enhance post-sale services, optimize processes, and ensure customer satisfaction. Collaborate across departments to implement scalable solution...
1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.