Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$79K - $83K *

Help us advance hearing solutions by providing clinical and sales support across North and Central Virginia. Join a dedicated team and develop expertise in cochlear implants while building strong cust...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Elevate your career with a dynamic team focused on innovative accounting solutions. Lead financial processes, ensure compliance, and drive efficiency in a fast-paced environment while collaborating cr...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$70K - $180K *

Drive impactful healthcare technology solutions through data-driven strategies, optimize customer engagements with compelling insights, and foster long-term partnerships for strategic growth...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$117K - $186K *

Play a key role in driving customer success by managing strategic partnerships, ensuring full adoption of hospital monitoring solutions, and collaborating with cross-functional teams to deliver clinic...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Elevate your career by managing a dynamic team, ensuring exceptional service delivery, and fostering employee development while driving customer satisfaction across diverse sectors...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$176K - $294K *

Contribute to building impactful relationships with Hematology thought leaders, crafting engagement strategies and insights to optimize Pfizer’s Hematology portfolio. Collaborate cross-functionally to...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $250K *

Join a dynamic team to enhance patient care by promoting innovative oncology solutions, educating healthcare providers, and driving strategic account management to elevate brand presence and improve p...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$176K - $294K *

Shape the future of oncology care by building strategic partnerships with key accounts, driving quality initiatives, and collaborating with cross-functional teams to enhance patient outcomes and align...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $250K *

Champion the promotion of innovative oncology solutions, enhancing patient care through strategic partnerships with healthcare providers and key opinion leaders, while driving brand growth and deliver...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$131K - $200K *

Join a team that's shaping the future of data platforms by developing scalable solutions for analytics and AI workloads. Collaborate on impactful projects using cutting-edge tools to enhance data reli...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $115K *

Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Shape the future of brand strategy by crafting distinct messaging and positioning for a diverse portfolio of university partners. Collaborate with cross-functional teams to optimize campaigns and enha...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $150K *

Lead the charge in transforming healthcare systems through data-driven insights and collaborative engagement. Drive performance improvement by managing analytics projects, delivering client solutions...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Advance your career by driving impactful Paid Social strategies across platforms like Meta and TikTok. Collaborate with cross-functional teams to optimize campaigns, leverage data insights, and enhanc...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$202K - $250K *

Champion data-driven decision-making by leading the development of integrated analytics and reporting strategies. Drive operational efficiency and financial performance through innovative data solutio...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Healthcare

$105K - $120K *

Join a dynamic team to lead and enhance information security programs, ensuring compliance and risk management across diverse industries. Collaborate with executives to develop strategies that protect...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$160K - $185K *

Lead the charge in developing compelling proposals for government contracts, managing the entire proposal process from strategy to submission. Collaborate with cross-functional teams to ensure complia...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Take ownership of comprehensive cyber risk assessments across the enterprise, articulating risks in business terms to ensure informed decision-making by leadership and helping to strengthen the organi...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $115K *

Accelerate your career by configuring and optimizing Workday solutions. Collaborate across teams to enhance HR operations and user experience through innovative system solutions and maintain data inte...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $154K *

Shape the future of AI by driving platform adoption, enhancing builder experiences, and managing the release lifecycle. Collaborate across teams to ensure governance and compliance while delivering me...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $154K *

Shape the future of AI by owning the enterprise context layer that empowers global AI agents. Collaborate with cross-functional teams to ensure accurate, governed, and timely context for enhanced oper...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $113K *

Unlock potential by leading complex revenue cycle projects, providing analytical support, and collaborating across departments to enhance billing processes and resolve financial issues in a fast-paced...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $141K *

Elevate digital experiences by developing and maintaining SharePoint solutions and Power Platform applications. Collaborate with stakeholders to create intuitive, automated workflows that enhance busi...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.